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SRNAPharmacology II > NSAIDS > Flashcards

NSAIDS Flashcards

1
Q

The principal cyclooxygenase product

A

arichidonic acid in platelets

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2
Q

What act as a stimulus for platelet aggregation and vasoconstriction?

A

Thromboxane

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3
Q

Ibuprofen should be stopped about

A

2 weeks

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4
Q

Enzyme is by low doses of aspirin

A

Irreversibly inhibited

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5
Q

NSAIDS enzyme is

A

reversibly inhibited

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6
Q

Prostacyclin is the most potent

A

Endogenous inhibitor of platelet aggregation, a potent vasodilator

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7
Q

Increase thromboxane would result in

A

decrease blood flow

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8
Q

Increase prostacyclin can lead to ?

A

bleeding

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9
Q

There has to be a normal ration of

A

Thromboxane to prostacyclin

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10
Q

Once patient has suffered from a heart attack

A

Low dose ASA is safe

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11
Q

Once patient has suffered from a heart attack

A

Low dose ASA is safe but before not really

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12
Q

Major site of prostaglandin synthesis

A

Lungs

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13
Q

ASA can lead to an increase in production of

A

leukotrienes

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14
Q

When you inhibit the other pathway

A

Leukotrienes become elevated

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15
Q

ASA block this pathway?

A

block arachidonic acid production

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16
Q

Because of increase leukotrienes, it

A

Can lead to Asthma

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17
Q

NSAIDs in asthma can exacerbate

A

Bronchoconstriction

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18
Q

Intrarenal release of prostaglandins by kidney

A

Modulate renal blood flow

inhibition of cyclooxygenase may lead to risk of acute renal injury.

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19
Q

Prostaglandins MOA

A

A

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20
Q

Intrarenal release of prostaglandins by kidney

A

Modulate renal blood flow
inhibition of cyclooxygenase may lead to risk of acute renal injury because it interferes with the renal prostaglandin protective

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21
Q

Cr greater than 1.3

A

Do not administer Toradol

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22
Q

Epoprosterenol use for

A

Treatment of primary pulmonary HTN

23
Q

Illoprost route of administration

A

Inhaled

24
Q

Illoprost is a derivative of

A

Prostacyclin

25
Q

Uniprost is administered

A

Administered subcutaneously portable pump

26
Q

Unapproved use

A

Pulmonary HTN with ARDS, Neonatal pulmonary HTN, CPB

27
Q

MOA of Epoprosternol

A

aka Prostacyclin and PGID2

STRONG VASODILATOR of ALL VASCULAR BEDS

28
Q

Epoprosterenol should be given by

A

Continuous transfusion

29
Q

Half life of Epoprosterenol

A

2-9 minutes

30
Q

Never do this with EPOPROSTERENOL

A

Never interrupt infusion

31
Q

Initial rate of EPO

A

2ng/kg/min

32
Q

Steady state levels are reached in

A

15 minutes

33
Q

EPO can be diagnostic also for

A

Pulmonary HTN

34
Q

Metabolism of EPO

A

rapidly hydrolyzed at neutral pH in blood , subject to enzymatic degradation

35
Q

Alprostadil aka

A

PGE1, Prostaglandins

36
Q

Use of Alprostadil

A

maintenance of ductus arteriosus in neonates with CHD

37
Q

Alprostadil use for

A

Hypotension while maintaining local CBF

38
Q

Also use for ED

A

Alprostadil

39
Q

Prostaglandins analogues mainly

A

Vasodilation and inhibition of platelet aggregation

40
Q

If you think you’re pregnant

A

Stay out of room where prolan is being administered

41
Q

MOA Alprostadil

A

Vasodilation

Inhibition of platelet aggreggation

42
Q

Dinoprostone uaw

A

Use to promote cervical ripening prior to labor induction

43
Q

Suppositories of Dinoprostone

A

Use to terminate pregnancy in week 12-28

44
Q

Dinoprostone caution

A

Use cuation in bronchospasm, asthmatic , seizure

45
Q

Carboprost (hemobate)

A

Produces uterine contractions

46
Q

Use of Carboprosts

A

Termination of pregnancy , tx of refractory postpartum uterine bleeding

47
Q

Misoprostil (Cytotec) use

A

Used to prevent NSAIDS-induced gastric ulcers, replace prostaglandins, and inhibits secretion of gastric acid

48
Q

Misoprostil Side effects include

A

Severe N/V, Diarrhea

Abdominal pain

49
Q

Flolan major side effects include

A

Abdominal issues

50
Q

Comparison:Thromboxane

A

Thomboxane Increse SVR< Airway resistance , Platelet aggr

51
Q

Protacylcin PGIe

A

SVR down
Airway res up
Platelet agg down

52
Q

Illoprosts decrease

A

SVR, airway resistance, platelet aggregation

53
Q

Epoprosterenol new drugs Treprostinil (remodulin)

A

Longer half life

Can interrupts therapy

54
Q

Trepostinil is a

A

Subcutaneous pump.

SRNAPharmacology II (32 decks)

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