NSAIDS Flashcards
(54 cards)
The principal cyclooxygenase product
arichidonic acid in platelets
What act as a stimulus for platelet aggregation and vasoconstriction?
Thromboxane
Ibuprofen should be stopped about
2 weeks
Enzyme is by low doses of aspirin
Irreversibly inhibited
NSAIDS enzyme is
reversibly inhibited
Prostacyclin is the most potent
Endogenous inhibitor of platelet aggregation, a potent vasodilator
Increase thromboxane would result in
decrease blood flow
Increase prostacyclin can lead to ?
bleeding
There has to be a normal ration of
Thromboxane to prostacyclin
Once patient has suffered from a heart attack
Low dose ASA is safe
Once patient has suffered from a heart attack
Low dose ASA is safe but before not really
Major site of prostaglandin synthesis
Lungs
ASA can lead to an increase in production of
leukotrienes
When you inhibit the other pathway
Leukotrienes become elevated
ASA block this pathway?
block arachidonic acid production
Because of increase leukotrienes, it
Can lead to Asthma
NSAIDs in asthma can exacerbate
Bronchoconstriction
Intrarenal release of prostaglandins by kidney
Modulate renal blood flow
inhibition of cyclooxygenase may lead to risk of acute renal injury.
Prostaglandins MOA
A
Intrarenal release of prostaglandins by kidney
Modulate renal blood flow
inhibition of cyclooxygenase may lead to risk of acute renal injury because it interferes with the renal prostaglandin protective
Cr greater than 1.3
Do not administer Toradol
Epoprosterenol use for
Treatment of primary pulmonary HTN
Illoprost route of administration
Inhaled
Illoprost is a derivative of
Prostacyclin
