FINAL Q&A

Question 1

Cyclooxygenase isozyme responsible for prostaglandin synthesis by cells involved in INFLAMMATION

Answer 1

Cox-2

Question 2

Among these mediators: most significant increase in vascular permeability–

a. prostaglandins
b. bradykinin
c. serotonin
d. leukotrienes

Answer 2

Leukotrienes

Question 3

Mediator in acute inflammation: pain

Answer 3

Bradykinin and prostaglandins

Question 4

Mediator of chronic inflammation (for example rheumatoid arthritis)

Answer 4

Interleukin

Question 5

Most nonsteroidal antiinflammatory drugs:

Answer 5

inhibit prostaglandin biosynthesis

Question 6

Initial drug of choice for treating most articular and musculoskeletal disorders (because of low-cost, safety, and efficacy)

Answer 6

ASA

Question 7

Aspirin: hydrolyzed to

Answer 7

acetic acid plus salicylate by tissue and blood esterases

Question 8

Acute attacks of gouty arthritis may occur early in treatment with allopurinol (Zyloprim, Purinol) because:

Answer 8

urate crystals move from tissue to plasma

Question 9

Previously most popular drug for treating inflammation of acute gouty arthritis – NSAIDs now more commonly used because of diarrhea associated with earlier medication:

Answer 9

Colchicine

Question 10

effective in management of mild to moderate pain, when anti-inflammatory action is not necessary

Answer 10

Acetaminophen