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SRNAPharmacology II > NonSteroidal Anti-inflammatory > Flashcards

NonSteroidal Anti-inflammatory Flashcards

1
Q

Nonsteroids Antiinflammatory

A

Antiinflammatory
Antipyretic
Analgesia
Platelet Aggregation

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2
Q

Is tylenol NSAIDS

A

no

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3
Q

5 cardinal signs of inflammation

A 
Tissue damage
Inflammation
More tissue damage
More prostaglandin release
More inflammation
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4
Q

Steroid in joint

A

Rest promote healing

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5
Q

Tissue inury

A

Increased Blood flow

Increase permeability

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6
Q

Phospholipase A2

A

Block arachidonic

Block leukotrienes pathway

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7
Q

Blocking COX

A

Leukotrienes

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8
Q

NSAIDs MOA

A

inhibition of cyclooxygenase ac/vity and the resultant decrease in the peripheral synthesis of prostaglandins

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9
Q

NSAIDS and opioids

A

decrease pot op opioids by 20-50%

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10
Q

Most common reaction is

A

Dyspepsia

Renal adverse effect

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11
Q

High bound to plasma proteins

A

NSAIDS

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12
Q

Acetaminophen a metabolite of

A

phenacetin is associated with the development of ESRD.

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13
Q

***Factors that favor NSAID induced nephrotoxicity include,

A

hypovolemia, preexisting renal disease, CHF,
sepsis, and combination with other nephrotoxic
drugs or radio contrast dyes, DM, and cirrhosis.

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14
Q

At risk for bleeding hold NSAIDs for

A

5 half lives

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15
Q

Hold aspirin for

A

7-10 days

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16
Q

Perioperative uses

A

By inhibi/ng cyclooxygenase and decreasing /ssue
prostaglandin synthesis, NSAIDs lead to decrease in
postopera/ve pain, and requirements for opioids.

17
Q

NSAIDS Summary

A

know benefits

No sedation, no respiratory depression , LESS NARCOTICS, less post op and vomiting

18
Q

Avoid NSAIDs in

A

renal failure

19
Q

Prevent MI patient from subsequent MI

A

ASPIRIN

20
Q

ASpirin more appropriate

A

post MI

21
Q

is the earliest sign of salicylate overdose.

A

Tinnitus

22
Q

Aspirin induced inhibition of platelets is

A

irreversible

and last the en/re life of the platelet.

23
Q

Life time of platelet

A

7-10 days

24
Q

Tylenol has

A

no antiinflammatory effects

25
Q

is a highly reactive metabolite which detoxified by conjugation with glutathione.

A

N-acetyl-p-benzoquinone (NABQI)

26
Q

• treat with ASA overdose

A

acetylcysteine (antioxidant substitute for glutathione)

27
Q

• treat with ASA overdose

A

acetylcysteine (antioxidant substitute for glutathione)

28
Q

Allopurinol use for

A

Hyperuricemia

29
Q

Allopurinol only

A

Prevent uric acid deposition , NOT USEFUL in acute attack

30
Q

Allopurinol can be used to

A

Prevent urice acid deposits

SRNAPharmacology II (32 decks)

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