APEX 2

Question 1

Which subunits must be occupied to open the nicotinic receptor at the motor end plate?

Answer 1

Alpha , Alpha (both channel must be bound for the channel to open)

Question 2

True about the EXTRA JUNCTIONAL receptors

Answer 2

They have a GAMMA instead of epsilon unit

Question 3

Fade during train of four stimulation is caused by

Answer 3

ANTAGONISM OF THE PRESYNAPTIC NICOTINIC RECEPTORS

Question 4

Fade during train of four stimulation is PREVENTED by

Answer 4

AGONISM OF THE PRESYNAPTIC NICOTINIC RECEPTORS

Question 5

Best characterizes phase II Block with succinylcholine

Answer 5

Fade with tetany

Prolonged Duration

Question 6

Absence of post tetanic potentiation which phase

Answer 6

Phase I

Question 7

Constant but diminished response to double burst stimulation

Answer 7

Phase I

Question 8

what differentiate the block ?

Answer 8

Presence or absence of a fade

Question 9

succinylcholine is an ______and is a phase__block

Answer 9

Agonist ; Phase I

Question 10

Phase II block done with succ resemble

Answer 10

NDNMB

Question 11

Most sensitive indicator of recovery of NMB

Answer 11

Inspiratory force is better than -40cm

Question 12

Normal side effect of Succinylcholine

Answer 12

Hypertension

Question 13

Most likely to cause anaphylaxis

Answer 13

Succinylcholine

Question 14

What are the ions that pass through the nicotinic recepotr

Answer 14

Calcium flows in
Sodium flows in
Potassium flows out
CHLORIDE IS NOT PART OF IT

Question 15

Which ANTIEMETIC can prolong succ duration of action

Answer 15

Metoclopramide

Question 16

How is myalgia minimized

Answer 16

Pretreatment with Nondepolarising,
LIDOCAINE
high dose rather than a lower dose

Question 17

Cisatracurium is prolonged by

Answer 17

Hypothermia

Question 18

Which inhaled anesthetics potentiates the NMB the MOST

Answer 18

DESFLURANE (DSINP)

Question 19

2 ABT that prolong vecuronium ( NDNMB)

Answer 19

Gentamicin

Clindamycin

Question 20

Which most likely to INCREASE AIRWAY RESISTANCE out of the NMB

Answer 20

MIVACURIUM and ATRACURIUM

Question 21

Stimulate histamine release from mast cells

Answer 21

MIVACURIUM and ATRACURIUM

Question 22

Best location to monitor onset

Answer 22

FACIAL NERVE

OBICULARIS OCULI

Question 23

Best location to monitor RECOVERY

Answer 23

Ulnar

Adductor policis

Question 24

Risk of pulmonary aspiration increase if TOF is less than _____ at the adductor pollicis

Answer 24

0.9

Question 25

Best acetylcholinesterase inhibitor to antagonize a block with 90 percent of twitch suppression

Answer 25

NEOGSTIGMINE

Question 26

Neogstimine antagonize activity by

Answer 26

Decreasing acetylcholine hydrolysis

Question 27

Smallest dose

Answer 27

more potent

Question 28

Largest dose

Answer 28

least potent

Question 29

Vessel rich group body WEIGHT not CO

Answer 29

10%

Question 30

Volatile with the lowest boiling point

Answer 30

Desflurane

Question 31

Describe how gas distributes between 2 Compartments at equillibrium?

Answer 31

Partition Coefficient

Question 32

How does Endobronchial intubaiton affect speed of inhalation induction?

Answer 32

Induction is prolonged

Question 33

An increase In CO affect the speed of inhalation by

Answer 33

Induction is prolonged

Question 34

Decrease CO ,

Answer 34

Decrease uptake, increase FA (faster induction)

Question 35

MAC is increased by

Answer 35

Hypernatremia

Question 36

Hepatic biotransformation is NDIS

Answer 36

NItro 0.004%
Des 0.02
Iso 0.2
Sevo 2-5%

Question 37

Hepatic biotransformation

Answer 37

Inorganic fluoride ions

TFA

Question 38

If the patient has a history of halothane hepatitis give

Answer 38

SEVO

Question 39

RIGHT to LEFT Intra cardiac shunt which is most affected

Answer 39

Desflurane
Sevoflurane
Isoflurane

Question 40

Right to left shunt and VA

Answer 40

slows the induction of FA/FI