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Neuro Block 2-RG > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

This NSAID binds platelets irreversibly

A

aspirin

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2
Q

This is the precursor metabolite required for prostaglandin, thromboxane, and prostacyclin synthesis

A

arachadonic acid

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3
Q

Function of prostaglandins

A

inflammation, vasodialation

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4
Q

Function of thromboxanes

A

increase platelet aggregation

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5
Q

Function of prostacyclins

A

decrease platelet aggregation

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6
Q

3 functional uses of NSAIDs

A

analgesic, antipyretic, anti-inflammatory

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7
Q

Which COX enzyme is responsible for normal physiological functions?

A

COX1

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8
Q

Which COX enzyme is inducible in an inflammatory response?

A

COX2

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9
Q

How do NSAIDs act as analgesics?

A

reduce PGE2 and PGI2 that normally sensitize nociceptors, decreasing threshold for nociceptor stimulation

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10
Q

How do NSAIDs act as an antipyretic?

A

PGE2 crosses BBB to hypothalamus, increase temp

NSAIDs block PG synthesis

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11
Q

Prostoglandins and prostocyclins together protect the stomach how?

A

decreasing H+ pumping

increasing mucosa secretion

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12
Q

Why might someone on aspirin be anemic?

A

GI bleeding

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13
Q

DC aspirin how long before surgery and why

A

1 wk

need new platelets

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14
Q

DC non-aspirin NSAIDs how long before surgery and why

A

2 days

t1/2 dependent

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15
Q

Presentation of Reye’s syndrome

A

child with viral illness who took aspirin

liver damage and encephalopathy

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16
Q

What is the pathophysiology of aspirin hypersensitivity?

A

shunting of AA to leukotrienes

17
Q

How do NSAIDs cause metabolic alkalosis?

A

PG move to respiratory center of medulla, increase respiration rate

18
Q

How does aspirin cause metabolic acidosis?

A

mitochondria uncoupling, increased lactate

19
Q

Long lasting NSAID

A

naproxen

20
Q

Celecoxib is selective for

A

COX2 inhibition

21
Q

Watch out for OD in this non-NSAID

A

what is acetaminophen?

22
Q

N-acetylcysteine is similar to glutathione and used to treat overdose of this medication that causes free radical formation

A

acetaminophen

23
Q

Do not drink EtOH and take…

A

acetaminophen

24
Q

Indomethacin is the treatment for

A

PDA

Neuro Block 2-RG (23 decks)

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