NSAIDs Flashcards
This NSAID binds platelets irreversibly
aspirin
This is the precursor metabolite required for prostaglandin, thromboxane, and prostacyclin synthesis
arachadonic acid
Function of prostaglandins
inflammation, vasodialation
Function of thromboxanes
increase platelet aggregation
Function of prostacyclins
decrease platelet aggregation
3 functional uses of NSAIDs
analgesic, antipyretic, anti-inflammatory
Which COX enzyme is responsible for normal physiological functions?
COX1
Which COX enzyme is inducible in an inflammatory response?
COX2
How do NSAIDs act as analgesics?
reduce PGE2 and PGI2 that normally sensitize nociceptors, decreasing threshold for nociceptor stimulation
How do NSAIDs act as an antipyretic?
PGE2 crosses BBB to hypothalamus, increase temp
NSAIDs block PG synthesis
Prostoglandins and prostocyclins together protect the stomach how?
decreasing H+ pumping
increasing mucosa secretion
Why might someone on aspirin be anemic?
GI bleeding
DC aspirin how long before surgery and why
1 wk
need new platelets
DC non-aspirin NSAIDs how long before surgery and why
2 days
t1/2 dependent
Presentation of Reye’s syndrome
child with viral illness who took aspirin
liver damage and encephalopathy
What is the pathophysiology of aspirin hypersensitivity?
shunting of AA to leukotrienes
How do NSAIDs cause metabolic alkalosis?
PG move to respiratory center of medulla, increase respiration rate
How does aspirin cause metabolic acidosis?
mitochondria uncoupling, increased lactate
Long lasting NSAID
naproxen
Celecoxib is selective for
COX2 inhibition
Watch out for OD in this non-NSAID
what is acetaminophen?
N-acetylcysteine is similar to glutathione and used to treat overdose of this medication that causes free radical formation
acetaminophen
Do not drink EtOH and take…
acetaminophen
Indomethacin is the treatment for
PDA
