Brain Neurotransmitter Systems Flashcards
What type of ion channel is the GABA channel?
Cl-
Two types of channels
ionotropic (fast)
metatropic (slow–G-protein coupled)
GABA: inhibitory or excitatory?
inhibitory
Postsynaptic glutamate receptors: inhibitory or excitatory
excitatory
Presynaptic glutamate receptors: inhibitory or excitatory?
inhibitory
Glycine as NT
inhibitory in CNS
Action of nAChR
open sodium channel
Action of mAChR
metabotropic improves memory (inhibitory)
Two types of dopamine receptors
D1 and D2
D1 receptors + disease
Gs (stimulatory)
increases cAMP production
Tourrette’s
D2 receptors + disease
Gi (inhibitory)
decreases cAMP production
Parkinsons
How does norepinephrine act on alpha-2 receptors?
increases K+ conductance
hyperpolarizes cells
Agonists of norepinephrine on alpha-2 receptors
muscle spasmalytics