Drug Deck

Question 1

3 generation cephalosporins (ceftriaxone)
mechanism
spectrum
resistance
side effects

Answer 1

• bind transpeptidases: inhibit cell wall synthesis
• Strep + Gram -
• inactivation by beta-lactamases
• allergy

Question 2

Amphotericin B
mechanism
spectrum
distribution
resistance
side effects

Answer 2

• ergosterol binding
• broad, systemic yeasts and molds
• liposomal, crosses BBB
• rare
• 70% nephrotoxicity b/c binds cholesterol

Question 3

Flucytosine
mechanism
spectrum
distribution
resistance
side effects

Answer 3

• antimetabolite in fungi (5-FU)
• yeast (Candida and Cryptococcus)
• oral, penetrates BBB
• to avoid: cotreat w/ amphotericin B
• bone marrow suppression

Question 4

Azoles
mechanism
spectrum
distribution
resistance
side effects

Answer 4

• binds P450 (Erg111) that makes ergosterol
• systemic mycoses and yeast
• orally available, EFFLUX TRANSPORTER SUBSTRATE
• altered P450
• drug-drug, neurotoxicity, hepatotoxicity, hormone synthesis (X pregnancy)