Encephalitis

Question 1

What type of symptoms are associated with encephalitis?

Answer 1

cerebral dysfunction

Question 2

Fever in encephalitis?

Answer 2

yes

Question 3

What is encephalopathy?

Answer 3

altered level of consciousness for 24 hr +

Question 4

What is the most common cause of encephalitis?

Answer 4

idiopathic

Question 5

What is the second most common cause of encephalitis?

Answer 5

herpes viruses

Question 6

Type of WBC found in CSF during encephalitis

Answer 6

lymphocytes

Question 7

MRI abnormality of HSV

Answer 7

temporal > frontal > other

Question 8

Alphaherpesvirus class

Answer 8

class I

Question 9

Most common encephalitis in HIV patients

Answer 9

VZV especially after stem cell transplant

Question 10

Acyclovir is activated by which enzyme?

Answer 10

thymidine kinase (alpha herpesviruses)

Question 11

What lobe of the brain do HSV encephalitis infections mostly affect?

Answer 11

temporal > frontal > other

Question 12

Encephalitis mortality rate

Answer 12

70%

Question 13

What antibody is present in CSF during initial infection?

Answer 13

IgM

Question 14

How is Dx of virus done in CSF?

Answer 14

PCR

Question 15

Microscopic findings of HSV?

Answer 15

• large, multinucleated cells

- Cowdry inclusions

Question 16

Most common viral cause of encephalitis in immunocompromised patients?

Answer 16

VZV (chickenpox or shingles)

Question 17

ADEM

Answer 17

acute disseminated encephalomyelitis

Question 18

ADEM cause

Answer 18

postinfectious

Question 19

SSPE

Answer 19

subacute sclerosising panecephalitis

• 6 to 15 yr. post measles
• type of acute disseminated encephalomyelitis

Question 20

Measles virus class

Answer 20

Group V
ssRNA-
enveloped

Question 21

Picorna virus class

Answer 21

Group IV
ssRNA+
nonenveloped