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Loco Pharmacology > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

Effects when COX-1 is inhibited

A

Prevention of cardiovascular events

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2
Q

Effects when COX-2 is inhibited

A

Anti inflammatory and anti analgesic effects

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3
Q

Drug regimen to treat pain caused by malignancy

A

NSAIDs + opioids

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4
Q

NSAIDs classification

A

a) Non-selective COX inhibitors
b) Selective COX-2 inhibitors (celecoxib, rofecoxib & valdecoxib)
c) Analgesic & antipyretic with poor anti inflammatory action (acetaminophen)

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5
Q

Which NSAID is a salicylate

A

Aspirin (acetylsalicylic acid)

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6
Q

Which NSAIDs are acetic acid derivatives

A

Indomethacin
Ketorolac
Nabumetone

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7
Q

Which NSAIDs are pyrazolone derivations

A

Oxyphenbutazone
Phenylbutazone

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8
Q

Which NSAIDS are propionic acid derivatives

A

Ibuprofen
Ketoprofen
Nepeoxen

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9
Q

Which class does Mephenmic acid belong to

A

Fenamate (category of non-selective COX inhibitors)

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10
Q

Which NSAIDs are enolic acid derivatives

A

Piroxicam
Tenoxicam

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11
Q

Lowest half-life of?

A

Aspirin 0.25h

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12
Q

Highest half-life of?

A

Oxaprozin 58h

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13
Q

Aspirin therapeutic dose

A

Low range (<300mg/d) anti platelet eff.
Intermediate range (300-2400mg/d) antipyretic & analgesic
High range (2400-4000mg/d) anti inflammatory eff.

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14
Q

Half-life of aspirin at low dose

A

3.5h

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15
Q

Half-life of aspirin at high dose

A

15h

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16
Q

Topical use of salicylic acid

A
  • Acne, corn, calluses and warts
  • In arthritis cream and sports rub as methyl salicylate
17
Q

Half-life of ibuprofen

A

2h

18
Q

Naproxen and Piroxicam used in?

A
  • Mild to moderate pain (arthritis and gout)
  • dysmenorrhea and headache
19
Q

Indomethacin used in?

A

Infants to close patent ductus arteriosus

20
Q

Only NSAID available in parenteral form

A

Ketorolac

21
Q

Aspirin drug interactions

A

Aspirin can displace warfarin, phenytoin or valproic acid resulting in higher free concentrations of these agents

22
Q

Aspirin chronic toxicity

A

Gastric ulceration
Upper GI bleeding
Acute renal failure
Interstitial nephritis

23
Q

Aspirin toxicity at high doses

A

Tinnitus
Vertigo
Hyperventilation
Respiratory acidosis

24
Q

Toxicity of Ketorolac

A

GI and renal damage with longer administration

25
Q

Toxicity of Indomethacin

A

Hematologic reactions

26
Q

Toxicity of rofecoxib and valdecoxib

A

Risk of MI and stroke

27
Q

Acetaminophen clinical use

A

Aspirin substitute esp. in children with viral infections and in those with any type of aspirin intolerance

28
Q

Acetaminophen half-life

A

2-3h

29
Q

Overdose effect and antidote of acetaminophen

A

Hepatotoxic
Acetylcysteine

30
Q

Preferred drug in pregnancy

A

Acetaminophen

31
Q

Why should NSAIDs be avoided in the third trimester

A

Risk of premature closure of ductus arteriosus

Loco Pharmacology (7 decks)

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