Glucocorticoids Flashcards
Agonists of corticosteroids
a) Glucocorticoids
b) Mineralocorticoids
Antagonists of corticosteroids
a) Receptor antagonist (glucocorticoid ant. & mineralocorticoid ant.)
b) Synthesis inhibitors
natural glucocorticoid
cortisol
natural mineralocorticoid
aldosterone
glucocorticoids effect on organs/tissues
a) inc. fat deposition on the face, shoulders and back
b) growth inhibited in children
c) osteoporosis
d) inhibit cell mediated immunologic functions (lymphotoxic)
e) anti-inflammatory response
cortisol causes what in patients with cushing syndrome and why
causes htn b/c of cortisol’s salt retaining effect. {high levels of cortisol in cushing syn.}
synthetic glucocorticoids names
prednisone
prednisolone
dexamethasone
triamcinolone
glucocorticoids for asthma
beclomethasone & budesonide
most potent anti-inflammatory steroid
dexamethasone
longest half life of which steroid
dexamethasone 24-36h
betamethasone clinical use
given to preg. women in premature labor to hasten the maturation of the fetal lungs
clinical uses of steroids
Addison’s disease (cortical insufficiency)
inflammatory/immunological disorders
chemotherapy induced vomiting
congenital adrenal hyperplasia
hematopoietic cancers
in adrenal hyperplasia what is the therapeutic eff. of glucocorticoid administration
suppression of ACTH secretion {adrenal hyperplasia = synthesis of abnormal forms of cortisol}
steroids toxicity
growth inhibition
muscle wasting
osteoporosis
salt retention
psychosis
mineralocorticoids names
aldosterone
fludrocortisone
