Glucocorticoids Flashcards
Agonists of corticosteroids
a) Glucocorticoids
b) Mineralocorticoids
Antagonists of corticosteroids
a) Receptor antagonist (glucocorticoid ant. & mineralocorticoid ant.)
b) Synthesis inhibitors
natural glucocorticoid
cortisol
natural mineralocorticoid
aldosterone
glucocorticoids effect on organs/tissues
a) inc. fat deposition on the face, shoulders and back
b) growth inhibited in children
c) osteoporosis
d) inhibit cell mediated immunologic functions (lymphotoxic)
e) anti-inflammatory response
cortisol causes what in patients with cushing syndrome and why
causes htn b/c of cortisol’s salt retaining effect. {high levels of cortisol in cushing syn.}
synthetic glucocorticoids names
prednisone
prednisolone
dexamethasone
triamcinolone
glucocorticoids for asthma
beclomethasone & budesonide
most potent anti-inflammatory steroid
dexamethasone
longest half life of which steroid
dexamethasone 24-36h
betamethasone clinical use
given to preg. women in premature labor to hasten the maturation of the fetal lungs
clinical uses of steroids
Addison’s disease (cortical insufficiency)
inflammatory/immunological disorders
chemotherapy induced vomiting
congenital adrenal hyperplasia
hematopoietic cancers
in adrenal hyperplasia what is the therapeutic eff. of glucocorticoid administration
suppression of ACTH secretion {adrenal hyperplasia = synthesis of abnormal forms of cortisol}
steroids toxicity
growth inhibition
muscle wasting
osteoporosis
salt retention
psychosis
mineralocorticoids names
aldosterone
fludrocortisone
more potent mineralocorticoid
fludrocortisone
corticosteroid receptor antagonist
spironolactone (aldosterone ant.)
eplerenon (aldosterone ant.)
mifepristone (glucocorticoid ant.)
treatment of cushing (high cortisol levels)
mifepristone
corticosteroid synthesis inhibitor names
ketoconazole
aminoglutethimide
metyrapone
clinical use of corticosteroid synthesis inhibitors
adrenal carcinoma
hirsutism
breast cancer
prostrate cancer
