Gout

Question 1

Acute gout management

Answer 1

NSAIDs (indomethacin)
glucocorticoids
colchicine

Question 2

prophylactic urate lowering therapy

Answer 2

low dose colchicine, low dose NSAIDs or corticosteroids for atleast 6mo

Question 3

Colchicine MoA

Answer 3

microtubule assembly inhibitor

Question 4

colchicine toxicity

Answer 4

nausea
vomiting
abdominal pain
diarrhea
myopathy, neutropenia, aplastic anemia and alopecia in chronic use

Question 5

chronic gout treatment strategies

Answer 5

a) xanthine oxidase inhibitors to reduce synthesis of uric acid
b) uricosuric drugs to increase uric acid excretion

Question 6

xanthine oxidase inhibitors

Answer 6

Allopurinol
Febuxostat

Question 7

Allopurinol toxicity

Answer 7

hypersensitivity reactions (skin rashes)

Question 8

Allopurinol & Febuxostat drug reactions

Answer 8

interferes with the metabolism of 6-mercaptopurine, azathioprine and theophylline

Question 9

uricosuric drug

Answer 9

Probenecid

Question 10

Probenecid MoA

Answer 10

blocks proximal tubular reabsorption of uric acid

Question 11

Probenecid drug reactions

Answer 11

inhibits the excretion of methotrexate, naproxen, ketoprofen & indomethacin