Eicosanoids

Question 1

Eicosanoids classification

Answer 1

1) Leukotrienes (LTB4, LTC4,LTD4)
2) Prostaglandins (PGE1, PGE2, PGF2)
Prostacyclin (PGI2)
Thromboxane (TXA2)

Question 2

Eicosanoids antagonists classification

Answer 2

1) Leukotriene antagonist {synthesis inhibitors and receptor blockers}
2) Prostaglandin antagonist {corticosteroids and NSAIDs}

Question 3

COX-1 expressed in?

Answer 3

most of the tissues

Question 4

COX-2 expression in?

Answer 4

brain and kidney
sites of inflammation

Question 5

vasodilators

Answer 5

PGE2
PGI2

Question 6

PGE2 functions

Answer 6

pain and inflammation response
increases body temp in fever
facilitates mucous secretion in the stomach
increases sperm motility
helps in labor

Question 7

PGI2 functions

Answer 7

vasodilation
inhibits platelet agg.

Question 8

antagonist of TXA2

Answer 8

PGI2

Question 9

TXA2 functions

Answer 9

vasoconstriction
platelet agg.

Question 10

bronchoconstriction caused by

Answer 10

excess leukotrienes can cause bronchoconstriction/asthma attack

Question 11

PGF2α function

Answer 11

reduces intraocular pressure

Question 12

Misoprostol clinical use

Answer 12

helps in menorrhagia
treat NSAIDs induced ulcers
abortifacient (misoprostol + mifepristone/methotrexate)

Question 13

Alprostadil clinical use

Answer 13

maintains the patency of ductus arteriosus in infants with transposition of great vessels until surgery
vasodilator
used in male impotence

Question 14

Dinoprostone clinical use

Answer 14

softens cervix before induction of labor

Question 15

Epoprostenol clinical use

Answer 15

in severe pulmonary HTN
prevents platelet agg. in dialysis machines

Question 16

Latanoprost clinical use

Answer 16

topical treatment of glaucoma