Rheumatoid Arthritis

Question 1

Drug therapy for RA

Answer 1

DMARDs as first line
NSAIDs or corticosteroids for symptomatic relief

Question 2

Methotrexate MoA

Answer 2

inhibits cytokine production and purine nucleotide biosynthesis, leading to immunosuppressive and anti-inflammatory effects

Question 3

Methotrexate toxicity

Answer 3

mucosal ulceration
nausea
cytopenia and liver cirrhosis on chronic use

Question 4

which DMARD adverse effects include ocular toxicity, irreversible corneal deposits and retinal damage

Answer 4

Hydroxychloroquine

Question 5

Name all DMARDs

Answer 5

Methotrexate
Hydroxychloroquine
Leflunomide
Minocycline
Sulfasalazine

Question 6

Anti-TNFα drugs

Answer 6

Adalimumab
Certolizumab
Etanercept
Golimumab
Infliximab

Question 7

Adalimumab also used for

Answer 7

psoriatic arthritis
ankylosing spondylitis
Crohn’s disease

Question 8

neutralizer of TNFα biological actions

Answer 8

Certolizumab
Golimumab

Question 9

Anti-TNFα drugs toxicity

Answer 9

increase risk for infection (TB,sepsis)
cause and/or worsen heart failure
increased risk of lymphomas and other cancers

Question 10

recombinant form of Anti-TNFα drug

Answer 10

Etanercept

Question 11

chimeric monoclonal antibody in Anti-TNFα drugs

Answer 11

Infliximab

Question 12

Abatacept MoA

Answer 12

blocks T-cell activation

Question 13

Abatacept toxicity

Answer 13

headaches
upper respiratory failure
nasopharyngitis
nausea

Question 14

Rituximab MoA

Answer 14

blocks B-cell activation

Question 15

Rituximab toxicity

Answer 15

infusion reaction

Question 16

which drug is administered prior to Rituximab infusion

Answer 16

Methyl prednisolone 30mins prior to each infusion

Question 17

Tocilizumab MoA

Answer 17

inhibits the action of IL-6

Question 18

Janus Kinase inhibitor drug

Answer 18

Tofacitinib

Question 19

Anakinra MoA

Answer 19

IL-1 receptor antagonist