NSAID

Question 1

COX-1

Answer 1

1) TXA-2: Vasoconstrictive, pro-coagulant

2) House-keeping PGE2: Gastric mucosa

Question 2

COX-2

Answer 2

Major inflammatory enzyme

1) PGI2 - prostacyclins
2) PGE2 - inflammation

Question 3

Platelets express which COX?

Answer 3

Express COX-1 and NOT COX-2

Question 4

Aspirin

Answer 4

1) Acetylates COX-1 Irreversible inhibitor -> INACTIVATES COX-1 for cell’s lifetime = anti-inflammatory
BLOCKS COX-1 in platelets -> anti-coagulant + platelets do not have nuclei to make more COX-1
2) Acetylates COX-2 -> Generates anti-inflammatory agent