Anti-Cytokine Drugs

Question 1

1) IMP dehydrogenase inhibitor

2) Prevents de novo purine biosynthesis

Answer 1

Mycophenolate Mofetil

Question 2

1) Prevents lymphocyte proliferation

2) Anti-inflammatory

Answer 2

Leflunomide, Methotrexate (DHTF reductase inhibitor)

Question 3

mAB against BAFF/BLYS [B cell activating factor]
BAFF (member of TNF family) = key determinant for B cell survival during tolerance dvlm -> Promote B cell survival and proliferation

Answer 3

Belimumab

Question 4

Treatment against lupus (overactive B cells)

Answer 4

Belimumab

Question 5

Anti-CD3 Ab (T cell marker) -

1) Used to prevent kidney/liver/heart organ rejection
2) Used to deplete donor T cells from bone marrow pre-bone marrow Tx to prevent GvHD

Answer 5

Muromonab

Question 6

Anti-IL2 Ab (Competitive inhibitor)

Used to prevent acute rejection post-kidney Tx

Answer 6

Dacluzimab

Question 7

anti-IL17 mAb

Used to treat psoriasis

Answer 7

Secukinumab

Question 8

anti-IgE mAb

Used to treat asthma potentially

Answer 8

Omalizumab

Question 9

anti-TNFalpha mAbs

Used against autoimmune diseases (e.g. Crohn’s, rheumatoid arthritis)

Answer 9

Infliximab
Etanercept
Adalimumab
Certolizumab

Question 10

Cytokine used for hepatitis C treatment

Answer 10

IFN-alpha

Question 11

1) Nucleoside Analog - BLOCKS Replication
2) BLOCKS de novo purine biosynthesis
Blocks T cell proliferation and IL proliferation

Answer 11

Azathioprine