Mucosal Immunology

Question 1

T cell marker that upregulates Th1 (present in the lamina propria) - specific to the gut

Answer 1

CD70

Question 2

Signaling molecule released by DC that direct T cells to effector tissue

Answer 2

RA -> a4b7 + CCR9

Question 3

Effector Tissue Layers of the Gut

Answer 3

Intraepithelial Cells (Induced and Natural) - CD8+ 
Lamina Propria - CD4+ (Th1 and Treg)

Question 4

Chemokine Receptor on the DC that actively participates in Ag capture from the gut lumen

Answer 4

CXCR3+ DCs

Question 5

Anti-inflammatory cytokines that decrease permeability (GOOD)

Answer 5

IL-10

TGF-beta

Question 6

Pro-inflammatory cytokines that increase permeability (BAD)

Answer 6

TNF-alpha
IFN-gamma
IL-13

Question 7

Dietary molecule that increases permeability

Answer 7

Glc

Question 8

Diff between iELs and nIELs

Answer 8

iELs - Rapidly activated to mediate attack on incoming pathogens [NOT directly recruited to gut -> Migrates through Peyer’s + Mesenteric lymph nodes]
nIELs - Maintain epithelial HOMEOSTASIS (maintenance and repair) by producing TGFbeta [DIRECTLY recruited to gut]

Question 9

Asthma is what Th response?

Answer 9

Amplified Th2 responses + Enhanced mast cell activity

Question 10

COPD is what response?

Answer 10

Th1 + Apoptotic Epithelial Cell deregulation

Question 11

Marker on T cell that upregulates Treg

Answer 11

CD103