NRSTS Flashcards
1
Q
common location of NRSTS
A
extremities, trunk (but can occur anywhere)
2
Q
most common NRSTS and translocation seen
A
synovial, associated with t(x;18)
3
Q
translocation assoc with infantile fibrosarcoma
A
t(12;15) ETV6-NTRK3 fusion
4
Q
what NRSTS is associated with NF1
A
MPNST (20-50% associated with NF1)
5
Q
treatment of NRSTS
A
surgery with RT if residual disease or high risk features, role of chemo is unclear
6
Q
chemo agents used in NRSTS
A
doxorubicin
ifosfamide
7
Q
which NRSTS is not sensitive to chemo?
A
alveolar soft part sarcoma
8
Q
which NRSTS are usually sensitive to chemo?
A
synovial sarcoma
undifferentiated sarcoma
9
Q
translocation in infantile fibrosarcoma
A
t(12;15)(p13;q25)
ETV6-NTRK3
Also seen in mesoblastic nephroma
