Hodgkin lymphoma Flashcards
age distribution of HL in industrialized countries
bimodal distribution - first peak in late adolescence/early 20s, second peak > 50 yrs
(in developing countries, early peak occurs before adolescence)
HL in children - what type of disease?
EBV-associated mixed-cellularity, nodular lymphocyte-predominant,
associations with adolescent / young adult HL?
- higher SES
- increased number of sibs
- early birth order (older sib)
most common type of HL in adolescents
nodular-sclerosing hodgkin lymphoma
what children are at increased risk of HL?
primary immunodeficiency, ALPS, HIV-infected children, post solid organ transplant
five year overall survival from HL
90-95%
what are b symptoms
unexplained fever x 3 days, drenching night sweats, weight loss >10% in preceding 6 months
what does a left supraclavicular node usually indicate
disease of thoracic para-aortic, spread up the thoracic duct
what does right supraclavicular node involvement indicate
usually mediastinal disease
non contiguous disease is more common in what pathology types
mixed cellularity, lymphocyte depleted
what pathology is characteristic of nodular sclerosing HL
collagen bands, lacunar variants of RS cells
Reed-sternberg cells - cell surface markers
CD 15 / CD 30
lack CD45
variable CD20
types of classical HL
- nodular sclerosing HL
- mixed cellularity HL (assoc with EBV)
- lymphocyte deplete (assoc with HIV)
- lymphocyte rich
what type is common in patients with HIV?
lymphocyte deplete HL (Usually EBV positive)
what type of HL is associated with popcorn cells
nodular lymphocyte predominant HL
