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Heme Onc Royal College > ALL > Flashcards

ALL Flashcards

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1
Q

what is the primary aim of AALL1331?

A

evaluating blinatumomab for patients with B ALL at first relapse

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2
Q

What is the translocation TEL-AML1 (ETV6-RUNX1)

A

t(12;21)(p13;q22)

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3
Q

what is a diagnostic criterion of T cell ALL that can’t be present in B cell?

A

cytoplasmic CD3

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4
Q

which chemotherapy agent has been implicated in significant toxicity in children with DS ALL?

A

methotrexate

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5
Q

what is a diagnostic criterion of T cell ALL that can’t be present in B cell?

A

cytoplasmic CD3

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6
Q

which chemotherapy agent has been implicated in significant toxicity in children with DS ALL?

A

methotrexate

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7
Q

risk of leukemia in identical twins?

A

if one twin develops leukemia within the first 5 yrs of life, the second twin has a 20% risk of developing leukemia

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8
Q

immunophenotype AML

A

MPO, CD117, CD13, CD33

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9
Q

histochemical stains positive in AML

A

non-specific esterases
MPO
sudan black

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10
Q

immunophenotype AML

A

MPO, CD117, CD13, CD33

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11
Q

list 5 genetic conditions that predispose to developing leukemia

A 
T21
Bloom
Fanconi
SDS
DBA
NF1
ataxia telangectasia
SCN
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12
Q

factors important in pathogenesis of leukemia

A
  • ionizing radiation
  • chemical exposure
  • drugs (ie, alkylators in AML)
  • genetics (20% risk of identical twin developing leukemia if other twin develops before 5 yrs of age, sibs have 4x increased risk)
  • chromosomal abnormalities (ie T21)
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13
Q

what translocation is found in the majority of burkitt’s lymphoma/leukemia

A

t(8;14) in 80%

between c-myc and IgH gene

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14
Q

what is an L3 phenotype associated with?

A

burkitt’s lymphoma/leukemia

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15
Q

what translocation is found in the majority of burkitt’s lymphoma/leukemia

A

t(8;14) in 80%

between c-myc and IgH gene

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16
Q

CNS1

A

no blasts on cytospin, no neurologic symptoms (regardless of CSF WBC)

17
Q

CNS2 definition

A

< 5 WBC on CSF + cytospin positive for blasts

18
Q

CNS1

A

no blasts on cytospin, no neurologic symptoms (regardless of CSF WBC)

19
Q

what type of leukemia is myeloperoxidase positive?

A

AML

20
Q

most common cytogenetic abnormalities in B precursor ALL

A
  • hyperdiploid (> 50 chromosomes, 25%)
  • ETV6-RUNX1 t(12;21) 25%
  • MLL rearrangements t(4;11) t(9;11) 8%
  • Ph-like (15-20%)
  • ERG deletion (7%)
  • E2A-PBX1 t(1;19) 5%
21
Q

x-ray finding associated with ALL

A

transverse metaphyseal bands, growth arrest lines, osteolytic lesions, osteopenia

22
Q

what is the steinherz/bleyer algorithm?

A

helps to determine if a traumatic tap should be classified as CNS3.

If CSF WBC/CSF RBC is > 2x more than blood WBC/blood RBC

23
Q

BCR-ABL1 translocation

A

t(9;22)(q34;q11)

24
Q

what is the steinherz/bleyer algorithm?

A

helps to determine if a traumatic tap should be classified as CNS3.

If CSF WBC/CSF RBC is > 2x more than blood WBC/blood RBC.

25
Q

BCR-ABL1 translocation

A

t(9;22)

26
Q

MLL rearrangement

A

t(v;11q23)

27
Q

hypodiploidy definition

A

< 44 chromosomes

28
Q

hyperdiploidy definition

A

> 50 chromosomes

29
Q

hypodiploidy definition

A

< 44 chromosomes

30
Q

size of protein product from BCR-ABL translocation CML

A

210 kDa

31
Q

What are the implications of a traumatic diagnostic LP?

A

upgrade to CNS2
use steinherz/bleyer algorithm to determine whether it should be considered CNS3

CSF WBC / CSF RBC > 2X blood WBC / blood RBC

32
Q

what is the absence of CD10 in precursor B cell ALL associated with?

A

MLL (KMT2A) rearrangements - specifically t(4;11) and a poor outcome

33
Q

What are the implications of a traumatic diagnostic LP?

A

upgrade to CNS2
use steinherz/bleyer algorithm to determine whether it should be considered CNS3

CSF WBC / CSF RBC > 2X blood WBC / blood RBC

34
Q

what is the absence of CD10 in precursor B cell ALL associated with?

A

MLL (KMT2A) rearrangements - specifically t(4;11) and a poor outcome

35
Q

what translocation is associated with cytoplasmic Ig?

A

t(1;19) TCF3-PBX1 (formerly known as E2A-PBX1)

36
Q

characteristics of Burkitt leukemia

A
  • surface Ig expression
  • FAB L3 morphology
  • MYC translocation
37
Q

T cell antigens

A

cytoplasmic CD3
CD7
CD2 or CD5

38
Q

What is the immunophenotype for T cell ALL

A

CD3, TdT, CD7

39
Q

What is immunophenotype for B lineage ALL

A

Combination of at least two of CD19, cCD79a or cCD22

Heme Onc Royal College (30 decks)

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