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Heme Onc Royal College > CML > Flashcards

CML Flashcards

You may prefer our related Brainscape-certified flashcards:
Royal College: Emergency Medicine flashcards
1
Q

what is the fusion gene found in CML?

A
  • BCR-ABL1
  • t(9;22)(q34;q11)
  • resulting in constitutive activation of tyrosine kinase ABL1
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2
Q

off target effects of imatinib

A
  • bone remodeling dysregulation / negative affect on bone mineral density
  • teratogenic effects
  • immune dysfunction (live vaccines not recommended)
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3
Q

what is CML?

A

myeloproliferative neoplasm characterized by dysregulated production / proliferation of mature / maturing granulocytes (predominantly neutrophils, also basophils / eosinophila)

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4
Q

phases of CML

A

chronic phase
accelerated phase
terminal blast crisis

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Heme Onc Royal College (30 decks)

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