Normal Function of the Nervous System Part 2 Flashcards
Part 4 Overview of the Central Nervous System
Major Divisions of the Central Nervous System
- (1)
- (1) - (3)
- (1)
- (1) - (2)
- (1) - 4)
- Spinal cord
-
Brain stem
- Medulla oblongata, Pons, Midbrain
- Cerebellum
-
Diencephalon
- Thalamus, Hypothalamus
-
Cerebrum
- Left and Right Cerebral hemispheres, Basal ganglia, Hippocampus, Amygdala
Major Divisions of the Central Nervous System (Notes)
- Spinal cord = goes through _____ bones - ends at ____ spine (divided into (3) regions)
-
Brain stem = _____, ____, _____ (bottom to top)
- Reponsible for ______ vegetative function = pumps ___, lungs ____
- Oldest part of the brain and most important for _____ of life
-
Cerebellum = lobe behind _____
- Important in _____ motor movements, helps regulate/___ tune movements and ____ and up____ our motor patterns no matter age, body changes
- ex) Signatures, “muscle ____” is not in the muscle is in the brain
- Important in _____ motor movements, helps regulate/___ tune movements and ____ and up____ our motor patterns no matter age, body changes
- vertebral, lumbar, (cervical, thoracic, lumbar)
-
medulla, pons, midbrain
- baseline vegetative function, heart, breathing
- maintenance
- midbrain
- learned motor movements, fine tune, updates, stores
- “muscle memory”
- learned motor movements, fine tune, updates, stores
Major Divisions of the Central Nervous System (Notes)
-
Diencephalon
- Thalamus = major _____ station for circuits that _____ one part of brain to another (grand central station)
-
Hypothalamus = controls baseline functions such as body t____, app_____, and f_____ behavior, libido and s____ appetite, re_____ function
- Part of the _____ system that regulates ______ responses
- Pituitary gland = _____ hypothalamus, connected and important in _____ system
-
Cerebrum = part of the brain that makes us most _____
- Left and Right Hemispheres = ____ brain function - C_______ (ie solving puzzles, sorting, evaluating, executive function like planning out your week)
- Hippocampus and Amygdala = also part of l____ system (emotions)
- Basal ganglia = controls ____ motor movements, regulates and makes them smooth
-
Diencephalon
- relay, connect
-
temp, appetite, feeding, sexual, reproductive
- limbic, emotional
- under, endocrine
-
Cerebrum, human
- higher, COGNITION
- limbic
- fine motor movements
Cerebrum Lobes
- Occipital lobe =
-
Temporal lobes =
-
Deep structures
- Hippocampus = (2)
- Amygdala = (2)
-
Deep structures
- Parietal lobe =
- Frontal lobe =
- Vision, Visual perception
- Hearing
- short term memory, learning
- alerts to danger, emotions (part of limbic system)
- Somatic sensation (more near frontal lobe), Spatial awareness
- Short term memory, planning future action, control of movements (motor, executive function, judgement, perception, deciding if something is a treat, choices that we make)
Another View of Brain Regions
Basal ganglia (nuclei) = important in ____ command
motor
Motor vs. Sensory Cortexes
-
Homunculus =
- Sizes of body part represents amount of ____ dedicated to sensing that structure
- Brain has great ______ (ie. someone blind who reads brail, area of cortex dedicated to fingertips will be larger)
- Sizes of body part represents amount of ____ dedicated to sensing that structure
- small man that maps regions of cerebral cortex
- cortex
- plasticity
- cortex
Motor vs. Sensory Cortex (Notes)
- Central Sulcus =
- Primary Motor Cortex =
- Primary Somatic Sensory Cortex
-
Parts of the brain that controls Motor Movements (3)
- Damage to basal ganglia or cerebellum causes _____ of muscle commands (lacks precision) dt lack of funneling
- Line in between frontal and parietal lobe
- Anterior area where all vountary movement originates (only exception is learned motor movements from cerebellum)
- Posterior area where all conscious sensation is perceived
-
Primary motor cortex (CEO in suite), Basal Ganglia (partners), and Cerebellum**(analysts)
- overshoot
The Language Circuit
- Wernicke’s Area =
- Angular Gyrus = part of ____ lobe - combines ____ input from the (1) area and other s_____ from the (2) cortexes and feeds into the ______ Area
-
Broca’s Area =
- What is it near?
- The connection between Broca’s and Wernicke’s is?
- Processes auditory input for language - imp for understanding speech
- temporal, auditory, primary auditory area, senses, somatosensory cortex and visual cortex -> Wernicke’s
- receives input from Wernicke’s area and controls production of intelligible speech
- primary motor area that controls tongue movements to form words
- Bidirectional to facilitate integration of speech formation, comprehension, and editing
The Language Circuit (Notes)
- Comprehension of language (not hearing but understanding)
- Combines auditory input and other senses and feeds into wernicke’s area
- Generation of language
- Wernicke’s Area
-
Angular Gyrus
- what you see, hear, feel -> puts it into wernicke’s
- ie. tone of voice, primary somato cortex telling AG she touched my shouler, prim visual telling AG thisis what her body position is like
- Broca’s
The Language Circuit (Notes)
- Wernicke and Broca’s relationship
- Wernicke and Broca are located bilaterally - for most ppl, language is comprehended and generated predominantly on the ____ side
- Some ppl think that wernicke’s on right side associated with?
- What type of aphasia happens when Wernicke’s is damaged?
- What type of aphasia happens when Broc’as is damaged?
- Bidirectional (they talk to each other)
- LEFT
- idiosyncratic understandings of things (weird meanings of words)
- Receptive aphasia
- Expressive aphasia (can’t even write it)
Brodmann’s Brain (52)
- Broadmann’s Brain =
- ___ regions (don’t need to memorize)
- Just know that these parts of the brain, sometimes are used bc are a more specific reference point to represent different functions
- Another way to classify parts of brain (probs most detailed)
- 52 regions
Glial Cells
=
(3)
Non-Neuronal supportive cells of the nervous system
Astrocytes
Oligondendrocytes
Ependymal Cells
Glial Cells (Notes)
- 2 types of cells in CNS (2)
- Glial Cells _____ neuronal function
- Astrocytes =
- Oligodendrocytes =
- Ependymal Cells =
- Neuronal and Non-Neuronal cells (glial cells)
- Support
- Important components of the blood brain barrier
- surrounds capillaries in the brain to help create a physical barrier to allow/prevent things to enter bloodstream
- Helps regulate composition of brain ECF (fluid that surrounds neuronal cells of brain and spinal cord), ECF is highly regulated and designed to reduce/control excitability of neuronal tissue
- Provide myelination to axons in the CNS
- Type of epithelial cell that forms walls of membranes of the ventricles
Meninges and Ependymal Cells
- Ventricular Spaces =
- Cranial bone =
-
Meninges =
- (3)
- space with no brain tissue, enclosed by membranes made up of ependymal cells and filled with CSF
- hard, inflexible protective structure of the brain
- brain is so fragile, if you put it down, it’ll spread out like jello
- brain is suspended in the cranium, attached to top of cranium bone and has a bit of a swing
- Layers underneath cranial bone
- Dura Mater, Sagittal Sinus
- Arachnoid mater, Subarachnoid space
- Pia Mater
Meninges
-
Dura Mater =
- (1)
-
Arachnoid Mater =
- (1)
- Pia Mater =
- Thick layer of extremely tough, fibrous tissue (green in pic)
- Sagittal Sinus = venous space that has sagittal vein that runs along sagittal plane
- Thin layer underneath dura mater
- Subarachnoid space = gap underneath arachnoid mater filled with blood vessels and CSF (yellow in pic)
- Layer right next to brain tissue
Ventricles of the Brain
Ventricles all ______
(4)
Connected
Left and Right Ventricles
3rd Ventricle (in between Left and Right)
4th Ventricle (connected to 3rd and central canal of spinal cord)
Brain Structure (Notes)
- Tiny ____ _____ moving through tissue
- ___ ___ ____ surrounds tissue
- _____ fluid between blood vessels and cells
- (2) types of fluid that neuronal cells in the CNS are exposed to
- Blood vessels
- Blood Brain Barrier
- Brain Extracellular Fluid
- CSF and Brain ECF (identical in composition, just produced in a slightly different way, and diff locations)
BECF vs. CSF (Notes)
- Extracellular Fluid =
- CSF =
- Choroid Plexus =
- Microcirculation =
- Gross circulation =
- in brains microcirculation areas, plasma gets filtered by BBB and becomes BECF
- fluid that occupies larger ventricular system and central canal of spinal cord
- produces CSF* (like the kidneys of brain, takes blood, filters it, and makes CSF)
- BBB filters plasma -> BECF
- Choroid Plexus filters blood -> CSF
Composition of Cerebrospinal Fluid Compared to Plasma
Notable Differences
CSF (___cellular) vs. Plasma (___cellular)
- Na
- K
- Mg
- Amino Acids/Proteins
- All these differences designed to control?
CSF extracellular, Plasma intracellular
- Less NA in CSF reduces its concentration gradient (usually pointing towards the cell)
- Less K in CSF increases its concentration gradient (usually pointing outwards from cell)/lowers membrane potential by making cell more negative, further away from threshold
- More Mg in CSF - interacts with sodium channels to reduce permeability and excitability
- Less AA/Protein - are neurotransmitters in brain (glutamate and Glysin are amino acids) so we want to control that
- Control and Reduce excitability -> AVOID SEIZURES
CSF Circulation
- CSF constantly produced by (1) -> circulates through (2) and then exits and removd from brain through (2) -> moves through (1) -> ___ of brain -> exits and drains to _____ sinus vein through (1) -> leaves brain and back into general circulation
- What connects ventricles to the subarachnoid space?
- Choroid plexus (____ of the brain) associated with each lateral and 3rd and 4th _____
- Purpose of constant circulation =
-
Choroid plexuses -> ventricles and central canal of spinal cord -> median and right lateral Aperatures -> subarachnoid space -> top of brain -> arachnoid granulations -> sagittal sinus
- Median and Right Lateral Aperatures
- kidneys, ventricles
- maintain composition of CSF in optimal place (O2, CO2, ions, glucose lvls)
Blood Brain Barrier
- A _____ structure composed of __ layers that represents barrier at the ____circulation level
(3)
- Mostly composed of plasma _______ -> therefore things that are ____ soluble can passively diffuse through these membranes
- Drugs that have SE of s_____/any effect of brain function -> can cross BBB
- physical, 3, microcirculation
Tight Junctions
Basement membrane
End feet of Astrocytes
- membrane, lipid
- Drugs that cause sedation -> can cross BBB