Nonspecific Interstitial Pneumonia

Question 1

HRCT of Idiopathic NSIP

Answer 1

Bilateral, subpleural ground-glass opacities
Often associated with lower lobe volume loss

Patchy areas of consolidation and reticular abnormalities may be present but honeycombing is unusual

Question 2

Key histopathologic feature of NSIP

Answer 2

Uniformity of intersitial involvement across the biopsy section, predominantly cellular or fibrosing

Less temporal and spatial heterogeneity than in UIP,
Little or no honeycombing is found

Question 3

Prognosis of NSIP

Answer 3

Good

5-year mortality rate at

Question 4

Clinical Manifestations of Idiopathic Nonspecific Interstitial Pneumonia

Answer 4

Younger Age
Most commonly in women who never smoked
Often associated with Febrile Illness