Cryptogenic Organizing Pneumonia

Question 1

Radiograph

Answer 1

Bilateral, patchy, or diffuse alveolar opacities in the presence of normal lung volume

Recurrent and migratory pulmonary opacities are common

Question 2

HRCT

Answer 2

Air-space consolidation, ground-glass opacities, small nodular opacities and bronchial wall thickening and dilation

Changes occur more frequently in the periphery of the lung and in the lower lung zones

Question 3

Histology

Answer 3

Granulation tissue within small airways, alveolar ducts abd airspaces with chronic inflammation in the surrounding alveoli

Question 4

Clinical manifestations

Answer 4

Onset at 5th to 6th decades

Presentation may be flu-like illness with cough, fever, malaise, fatigue and weight loss