ILD- Cigarette Smoking

Question 1

Histologic Hallmark of desquamative interstitial pneumonia

Answer 1

Extensive accumulation of macrophages in intraalveolar spaces with minimal interstitial fibrosis

Question 2

Hallmark histologic finding of desquamative interstitial pneumonia

Answer 2

Diffuse and uniform accumulation of macrophages in the alveolar spaces

Question 3

Prognosis of Desquamative Interstitial Pneumonia

Answer 3

Better prognosis

10-Year Survival rate of ~70%

Question 4

HRCT of RB-ILD

Answer 4

Bronchial wall thickening, centrilobular nodules, ground-glass opacity and emphysema with air trapping

Question 5

Radiographic findings of Pulmonary Langerhans Cell Histiocytosis

Answer 5

Ill-defined or stellate nodules (2-10mm in diameter) 
Reticular or nodular opacities 
Bizaare-shaped upper zone cysts 
Preservation of lung volumes
Sparing of the costophrenic angles 

*Combination of nodules and thin-walled cysts are virtually diagnostic of PLCH

Question 6

Most common pulmonary function abnormality in PLCH

Answer 6

Markedly reduced DLCO

Question 7

Characteristic Histopathologic finding in PLCH

Answer 7

Presence of nodular sclerosing lesions (poorly defined, distributed in bronchiolocentric fashion with intervening normal parenchyma) that contain Langerhans cells accompanied by mixed celiular infiltrates

Question 8

ILD associated with cigarette smoking

Answer 8

1. Desquamative Interstitial pneumonia
2. Respiratory Bronchiolitis- Associated ILD
3. Pulmonary Langerhans Cell Histiocytosis