Non-HIV Antiviral Flashcards

1
Q

How are flus named?

A

surface antigens H (hemagglutinin) and N (neuraminidase), eg H1N1 and H3N2

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2
Q

Strategies for flu management

A

prevention, antiviral, symptoms

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3
Q

three types of flu vaccines

A

inactivated, recombinant, attenuated

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4
Q

SE of flu vaccine

A

soreness, fever, myalgia, malaise

These are immune system reactions, not the flu itself

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5
Q

Severe, rare side effect of flu vaccine

A

Guillan-Barre – immune response that leads to weakness and potential paralysis. Usually reversible.

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6
Q

What type of flu vaccine should someone with an egg allergy take?

A

Any! But to avoid any concerns, recombinant hemagglutinin vaccine (RIV) are an egg-free option

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7
Q

Who should not take the live, attenuated influenza vaccine (nasal spray)?

A

Kids under 2, immunocompromised, gestating parents AND THEIR FAMILIES

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8
Q

When should flu vaccine be administered

A

October/November, potential booster in April for >65 or immunocompromised

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9
Q

Is egg allergy a contraindication for the flu vaccine

A

No, but monitor for 15 minutes

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10
Q

Brand name of Oseltamivir

A

Tamiflu

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11
Q

t/f: Tamiflu can be used for only prophylaxis

A

false, prophylaxis and treatment

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12
Q

Drug class of oseltamivir (Tamiflu)

A

neuroaminidase inhibitor

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13
Q

Timing considerations for Tamiflu

A
  • no more than 2 days after symptoms first appear (ideally within 12 hours)
  • prophylaxis up to 10 days
  • discontinue 48 hours before live attenuated influenza vaccine
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14
Q

AE for oseltamivir (Tamiflu)

A

Rare: SJS, neuropsych in young

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15
Q

Which hepatitis doesn’t have a vaccine

A

Hep C

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16
Q

Hep C’s 3 Cs

A

chronic, cirrhosis, cancer

17
Q

Drug treatment for Hep B

A

Not treated unless active liver disease. Aren’t great options. Can potentially use interferon alpha or anti-HIV drugs.

18
Q

Best treatment option for Hep B

A

prevent with vaccine

19
Q

Hep C treatment cure rate

A

95-99%

20
Q

Hep C treatment AE

A

nausea, fatigue, weakness. Watch liver function tests.

21
Q

Hep C treatment drug-drug interactions

A

antacids, lipid-lowering, anti-seizure, antiretroviral