Non alcoholic fatty liver disease Flashcards
1
Q
define NASH?
A
a term used to describe a range of conditions caused by the build-up of fat in the liver due to causes other than excessive alcohol use
2
Q
what are the levels of NASH?
A
- steatosis
- steatophepatitis
- fibrosis
- liver cirrhosis
3
Q
what are the risk factors of NASH?
A
- obesity
- T2DM
- hypertension
- Hypercholesterolaemia
- age > 50 years
- smoking
- starvation
4
Q
what does NASH increase the risk of?
A
- T2DM
- MI
- Stroke
5
Q
what is the epidemiology of NASH?
A
- most common liver disorder in the UK
- 1/3 of people have early stages of NASH
6
Q
what are the presenting symptoms of NASH?
A
- usually there are no symptoms in the early stages
- occasional symptoms inclufe
- aching RUQ pain
- fatigue
- unexplained weight loss
- weakness
7
Q
what are the signs of NASH on physical examination?
A
- RUQ tenderness
- hepatomegaly
- signs of cirrhosis
8
Q
what investigations should be carried out for NASH?
A
- LFTs
- Liver USS
- ELF blood test
- liver biopsy
9
Q
what are the conservative measures that can be taken for NASH?
A
- one can lose weight
- reduce BP
- control diabetes
- reduce cholestrol
- stop smoking
- exercise regularly
- reduce alcohol consumption
10
Q
what are the complications of NASH?
A
- cirrhosis
- ascites
- varices
- hepatic encephalopathy
- hepatocellular carcinoma
- liver failure
11
Q
prognosis for NASH?
A
- 20% go on to develop cirrhosis
