NMBs

Question 1

Sux ED95

Answer 1

0.3 mg/kg

Question 2

Sux typical intubating dose

Answer 2

1 mg/kg

Question 3

Sux onset

Answer 3

45-60 seconds

Question 4

Sux duration

Answer 4

8-15 minutes

Question 5

Dantrolene Initial Dose

Answer 5

2 mg/kg

Question 6

Dantrolene re-dose up to ___ to stop MH crisis

Answer 6

10 mg/kg

Question 7

Cis-Atracurium ED95

Answer 7

0.05 mg/kg

Question 8

Cis-Atracurium Onset

Answer 8

3-7 min

Question 9

Cis-Atracurium Duration

Answer 9

20-35 min

Question 10

Cis-Atracurium typical intubating dose

Answer 10

0.1-0.2 mg/kg

Question 11

Cis-Atracurium duration of an intubating dose

Answer 11

60-70 min

Question 12

Vec ED95

Answer 12

0.05 mg/kg

Question 13

Vec typical intubating dose

Answer 13

0.1-0.2 mg/kg

Question 14

Vec duration of an intubating dose

Answer 14

25-45 min

Question 15

Vec onset

Answer 15

3-4 min

Question 16

Roc ED95

Answer 16

0.3 mg/kg

Question 17

Roc ED95 onset

Answer 17

3-5 min

Question 18

Roc ED95 duration

Answer 18

18-30 min

Question 19

Roc typical intubating dose

Answer 19

0.6 mg/kg

Question 20

Roc duration of an intubating dose

Answer 20

25-45 min

Question 21

Roc dose to achieve 60 sec onset

Answer 21

1.2 mg/kg

Question 22

Roc duration of 1.2 mg/kg dose

Answer 22

60-90-120 min

Question 23

Neostigmine typical dose

Answer 23

0.04-0.08 mg/kg (40-80 mcg)

Question 24

Glyco dose for 40-80 mcg Neostigmine

Answer 24

0.2 mg/mg Neo

Question 25

Atropine dose for 40-80 mcg Neostigmine

Answer 25

0.2-0.3 mg/kg

Question 26

Neostigmine Onset

Answer 26

5 min | Peak: 10 min

Question 27

Sugammadex dose for Deep block

Answer 27

4 mg/kg

Question 28

Neostigmine Duration of action

Answer 28

60 min

Question 29

Sugammadex works on which NDMRs?

Answer 29

Roc | Vec

Question 30

Sugammadex dose for Moderate block (2 twitches)

Answer 30

2 mg/kg

Question 31

Sugammadex reversal for Deep block time for TOF return to 90%

Answer 31

2.1-4.3 min

Question 32

Sugammadex reversal for moderate block time for TOF return to 90%

Answer 32

1.2-1.7 min

Question 33

DOA for top 4

Answer 33

Sux: ultrashort Roc: intermediate Vec: intermediate Cis: Intermediate

Question 34

Atracurium onset

Answer 34

3-4 min

Question 35

Atracurium DOA

Answer 35

30-45 min

Question 36

Atracurium ED95 & Intubating dose

Answer 36

0. 25 mg/kg | 0. 5 mg/kg

Question 37

NMBs that cause histamine release

Answer 37

``` Sux Atracurium (dose-dependent) [and also Miva, d-Tubo & Metocurine all dose-dependent] ```

Question 38

NMB with NO histamine release

Answer 38

cis vec roc

Question 39

NMB with effects on HR and BP

Answer 39

Sux (Tachy and Brady / decrease) Atracurium (reflex tachy / minimal) Vec and Roc (minimal / minimal)

Question 40

NMB with NO effects on HR or BP

Answer 40

Cis

Question 41

NMB that effect Autonomic Ganglia

Answer 41

Sux | Miva + Atracurium are dose-dependent

Question 42

ED50 of a muscle relaxant indicates:

Answer 42

dose at which a muscle relaxant produces a 50% depression of twitch tension in the nACHr

Question 43

Twitch response may not be reduced until ____% of NaChR are blocked

Answer 43

70%

Question 44

Twitch is completely eliminated when ___% of receptors are blocked

Answer 44

90%

Question 45

2 groups of non-depolarizing muscle relaxants:

Answer 45

benzylisoquinolinium and | aminosteroid

Question 46

Neostigmine, pyridostigmine & Edrophonium are examples of _____

Answer 46

anti-cholinesterases

Question 47

reversal of NDMRs by anticholinesterases are (competitive and reversible OR non-competitive and non-reversible)

Answer 47

competitive and reversible

Question 48

at NMJ what electrolyte disturbances INCREASE & DECREASE NT release

Answer 48

Increase: hypercalcemia & hypomagnesemia Decrease: hypocalcemia & hypermagnesemia

Question 49

Metabolism of Sux

Answer 49

butyrylcholinesterase

Question 50

partially metabolized by hofmann elimination

Answer 50

atracurium | cis-atracurium

Question 51

muscle relaxants affect which structures FIRST?

Answer 51

Diaphragm | Larynx

Question 52

Which medications are known to cause resistance to DMRs? (aminoglycosides, anticonvulsants, antiarrhythmics, tetracyclines)

Answer 52

anticonvulsants

Question 53

expected duration of Sux with Dibucane 70-80

Answer 53

9-13 min

Question 54

expected duration of Sux with Dibucane 50-60

Answer 54

15-30 min

Question 55

expected duration of Sux with Dibucane 20-30

Answer 55

4-24 hours

Question 56

Succinylcholine stimulation of which receptors results in bradycardia?

Answer 56

muscarinic SA node receptors