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Anesthesia Fast Facts > NMBs > Flashcards

NMBs Flashcards

1
Q

Sux ED95

A

0.3 mg/kg

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2
Q

Sux typical intubating dose

A

1 mg/kg

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3
Q

Sux onset

A

45-60 seconds

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4
Q

Sux duration

A

8-15 minutes

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5
Q

Dantrolene Initial Dose

A

2 mg/kg

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6
Q

Dantrolene re-dose up to ___ to stop MH crisis

A

10 mg/kg

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7
Q

Cis-Atracurium ED95

A

0.05 mg/kg

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8
Q

Cis-Atracurium Onset

A

3-7 min

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9
Q

Cis-Atracurium Duration

A

20-35 min

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10
Q

Cis-Atracurium typical intubating dose

A

0.1-0.2 mg/kg

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11
Q

Cis-Atracurium duration of an intubating dose

A

60-70 min

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12
Q

Vec ED95

A

0.05 mg/kg

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13
Q

Vec typical intubating dose

A

0.1-0.2 mg/kg

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14
Q

Vec duration of an intubating dose

A

25-45 min

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15
Q

Vec onset

A

3-4 min

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16
Q

Roc ED95

A

0.3 mg/kg

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17
Q

Roc ED95 onset

A

3-5 min

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18
Q

Roc ED95 duration

A

18-30 min

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19
Q

Roc typical intubating dose

A

0.6 mg/kg

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20
Q

Roc duration of an intubating dose

A

25-45 min

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21
Q

Roc dose to achieve 60 sec onset

A

1.2 mg/kg

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22
Q

Roc duration of 1.2 mg/kg dose

A

60-90-120 min

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23
Q

Neostigmine typical dose

A

0.04-0.08 mg/kg (40-80 mcg)

24
Q

Glyco dose for 40-80 mcg Neostigmine

A

0.2 mg/mg Neo

25
Q

Atropine dose for 40-80 mcg Neostigmine

A

0.2-0.3 mg/kg

26
Q

Neostigmine Onset

A

5 min

Peak: 10 min

27
Q

Sugammadex dose for Deep block

A

4 mg/kg

28
Q

Neostigmine Duration of action

A

60 min

29
Q

Sugammadex works on which NDMRs?

A

Roc

Vec

30
Q

Sugammadex dose for Moderate block (2 twitches)

A

2 mg/kg

31
Q

Sugammadex reversal for Deep block time for TOF return to 90%

A

2.1-4.3 min

32
Q

Sugammadex reversal for moderate block time for TOF return to 90%

A

1.2-1.7 min

33
Q

DOA for top 4

A

Sux: ultrashort
Roc: intermediate
Vec: intermediate
Cis: Intermediate

34
Q

Atracurium onset

A

3-4 min

35
Q

Atracurium DOA

A

30-45 min

36
Q

Atracurium ED95 & Intubating dose

A
  1. 25 mg/kg

0. 5 mg/kg

37
Q

NMBs that cause histamine release

A 
Sux
Atracurium (dose-dependent)
[and also Miva, d-Tubo & Metocurine all dose-dependent]
38
Q

NMB with NO histamine release

A

cis
vec
roc

39
Q

NMB with effects on HR and BP

A

Sux (Tachy and Brady / decrease)
Atracurium (reflex tachy / minimal)
Vec and Roc (minimal / minimal)

40
Q

NMB with NO effects on HR or BP

A

Cis

41
Q

NMB that effect Autonomic Ganglia

A

Sux

Miva + Atracurium are dose-dependent

42
Q

ED50 of a muscle relaxant indicates:

A

dose at which a muscle relaxant produces a 50% depression of twitch tension in the nACHr

43
Q

Twitch response may not be reduced until ____% of NaChR are blocked

A

70%

44
Q

Twitch is completely eliminated when ___% of receptors are blocked

A

90%

45
Q

2 groups of non-depolarizing muscle relaxants:

A

benzylisoquinolinium and

aminosteroid

46
Q

Neostigmine, pyridostigmine & Edrophonium are examples of _____

A

anti-cholinesterases

47
Q

reversal of NDMRs by anticholinesterases are (competitive and reversible OR non-competitive and non-reversible)

A

competitive and reversible

48
Q

at NMJ what electrolyte disturbances INCREASE & DECREASE NT release

A

Increase: hypercalcemia & hypomagnesemia

Decrease: hypocalcemia & hypermagnesemia

49
Q

Metabolism of Sux

A

butyrylcholinesterase

50
Q

partially metabolized by hofmann elimination

A

atracurium

cis-atracurium

51
Q

muscle relaxants affect which structures FIRST?

A

Diaphragm

Larynx

52
Q

Which medications are known to cause resistance to DMRs? (aminoglycosides, anticonvulsants, antiarrhythmics, tetracyclines)

A

anticonvulsants

53
Q

expected duration of Sux with Dibucane 70-80

A

9-13 min

54
Q

expected duration of Sux with Dibucane 50-60

A

15-30 min

55
Q

expected duration of Sux with Dibucane 20-30

A

4-24 hours

56
Q

Succinylcholine stimulation of which receptors results in bradycardia?

A

muscarinic SA node receptors

Anesthesia Fast Facts (24 decks)

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