NMBs Flashcards
Sux ED95
0.3 mg/kg
Sux typical intubating dose
1 mg/kg
Sux onset
45-60 seconds
Sux duration
8-15 minutes
Dantrolene Initial Dose
2 mg/kg
Dantrolene re-dose up to ___ to stop MH crisis
10 mg/kg
Cis-Atracurium ED95
0.05 mg/kg
Cis-Atracurium Onset
3-7 min
Cis-Atracurium Duration
20-35 min
Cis-Atracurium typical intubating dose
0.1-0.2 mg/kg
Cis-Atracurium duration of an intubating dose
60-70 min
Vec ED95
0.05 mg/kg
Vec typical intubating dose
0.1-0.2 mg/kg
Vec duration of an intubating dose
25-45 min
Vec onset
3-4 min
Roc ED95
0.3 mg/kg
Roc ED95 onset
3-5 min
Roc ED95 duration
18-30 min
Roc typical intubating dose
0.6 mg/kg
Roc duration of an intubating dose
25-45 min
Roc dose to achieve 60 sec onset
1.2 mg/kg
Roc duration of 1.2 mg/kg dose
60-90-120 min
Neostigmine typical dose
0.04-0.08 mg/kg (40-80 mcg)
Glyco dose for 40-80 mcg Neostigmine
0.2 mg/mg Neo
Atropine dose for 40-80 mcg Neostigmine
0.2-0.3 mg/kg
Neostigmine Onset
5 min
Peak: 10 min
Sugammadex dose for Deep block
4 mg/kg
Neostigmine Duration of action
60 min
Sugammadex works on which NDMRs?
Roc
Vec
Sugammadex dose for Moderate block (2 twitches)
2 mg/kg
Sugammadex reversal for Deep block time for TOF return to 90%
2.1-4.3 min
Sugammadex reversal for moderate block time for TOF return to 90%
1.2-1.7 min
DOA for top 4
Sux: ultrashort
Roc: intermediate
Vec: intermediate
Cis: Intermediate
Atracurium onset
3-4 min
Atracurium DOA
30-45 min
Atracurium ED95 & Intubating dose
- 25 mg/kg
0. 5 mg/kg
NMBs that cause histamine release
Sux Atracurium (dose-dependent) [and also Miva, d-Tubo & Metocurine all dose-dependent]
NMB with NO histamine release
cis
vec
roc
NMB with effects on HR and BP
Sux (Tachy and Brady / decrease)
Atracurium (reflex tachy / minimal)
Vec and Roc (minimal / minimal)
NMB with NO effects on HR or BP
Cis
NMB that effect Autonomic Ganglia
Sux
Miva + Atracurium are dose-dependent
ED50 of a muscle relaxant indicates:
dose at which a muscle relaxant produces a 50% depression of twitch tension in the nACHr
Twitch response may not be reduced until ____% of NaChR are blocked
70%
Twitch is completely eliminated when ___% of receptors are blocked
90%
2 groups of non-depolarizing muscle relaxants:
benzylisoquinolinium and
aminosteroid
Neostigmine, pyridostigmine & Edrophonium are examples of _____
anti-cholinesterases
reversal of NDMRs by anticholinesterases are (competitive and reversible OR non-competitive and non-reversible)
competitive and reversible
at NMJ what electrolyte disturbances INCREASE & DECREASE NT release
Increase: hypercalcemia & hypomagnesemia
Decrease: hypocalcemia & hypermagnesemia
Metabolism of Sux
butyrylcholinesterase
partially metabolized by hofmann elimination
atracurium
cis-atracurium
muscle relaxants affect which structures FIRST?
Diaphragm
Larynx
Which medications are known to cause resistance to DMRs? (aminoglycosides, anticonvulsants, antiarrhythmics, tetracyclines)
anticonvulsants
expected duration of Sux with Dibucane 70-80
9-13 min
expected duration of Sux with Dibucane 50-60
15-30 min
expected duration of Sux with Dibucane 20-30
4-24 hours
Succinylcholine stimulation of which receptors results in bradycardia?
muscarinic SA node receptors
