IV Anesthetics Flashcards

1
Q

Propofol MOA

A

GABA(A) agonist

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2
Q

Propofol Infusion Sedation

A

25-100 mcg/kg/min

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3
Q

Propofol Infusion TIVA

A

100-300 mcg/kg/min

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4
Q

Propofol Induction Dose

A
  1. 5-2.5 mg/kg -Adults

2. 5-3.5 mg/kg -Peds

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5
Q

Etomidate MOA

A

GABA(A) modulation

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6
Q

Etomidate Induction Dose

A

0.2-0.4 mg/kg

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7
Q

Ketamine MOA

A

NMDA Antagonist

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8
Q

Ketamine Induction Dose

A

1-3 mg/kg IV

4-8 mg/kg IM

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9
Q

Ketamine as an adjunct analgesic

A

0.2-0.5 mg/kg

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10
Q

Ketamine Infusion

A

2-15 mcg/kg/min

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11
Q

Dex MOA

A

alpha 2 agonist

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12
Q

Dex premed dose

A

0.33-0.67 mcg/kg 15 minutes before surgery

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13
Q

Dex MAC dosing

A

1 mcg/kg over 10 minutes and then 0.7 mcg/kg/min keeps BIS 70-80

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14
Q

Barbituates MOA

A

GABA(A) agonist

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15
Q

Benzodiazepine MOA

A

GABA(A) agonist

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16
Q

Midazolam Dose

A
  1. 5-4 mg IV - Adults
    - often 2mg bc that is what is in a vial

0.1-0.2 mg/kg IV -Peds

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17
Q

Diazepam dose

A

5-10 mg IV -Adults

0.2-0.3 mg/kg IV -Peds

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18
Q

Lorazepam PO pre-med dose

A

0.5-2.0 mg at HS and 0.5-2.0 mg PO at 0600

19
Q

Thiopental induction dose

20
Q

Methohexital induction dose

A

1-1.5 mg/kg

21
Q

Lorazepam dosing for amnesia

A

50 mcg/kg (max 4 mg) amnesia for 6 hours

22
Q

IV anesthetic that preserves CV function

23
Q

Most Common IV anesthetic

24
Q

May cause R on T and Torsades

A

Droperidol

25
Antiemetics that cause sedation
Droperidol | Scopolamine
26
IV Anesthetics that cause pain at the injection site
Propofol | Etomidate
27
Cons to Ketamine
dysphoria, hallucinations, emergence delirium increases BP, HR, ICP, CBF, CMRO2 (don't use in neuro cases)
28
Amnestics
Benzos: Midazolam, Diazepam, Lorazepam
29
Hypnotics
Sodium Thiopental, Propofol, Etomidate
30
Analgesics
Opioids: Morphine, Meperidine, Fentanyl, Alfentanyl, Sufentanil, Remifentanil
31
Anxiolytics
``` Propofol Barbiturates (NaPentothal, Methohexital, Thiamylal) Etomidate Ketamine Benzos (Diazepam, Midazolam, Lorazepam) Opioids ```
32
Paralytics
Succinylcholine, Mivacurium, Rocuronium, Cisatracurium, Vecuronium, Pancuronium, Curare
33
Flumazenil
BZD reversal (competitive antagonist)
34
Propofol decreases PONV (T/F)
True
35
Propofol Infusion Syndrom
(PRIS) is a life-threatening condition characterized by acute refractory bradycardia progressing to asystole and one or more of: metabolic acidosis. rhabdomyolysis. hyperlipidemia. enlarged or fatty liver. Typically with longer infusions and higher doses
36
Etomidate Cons
causes myoclonus increases PONV provides no analgesia ***adrenal suppression***
37
Barbiturates Cons
May cause hyperalgesia, can cause histamine release, Extravasation causes tissue sloughing, do not mix with succ (will make "concrete"), intraarterial injection causes severe vasoconstriction, induces the P450 system, contraindicated in patients with acute intermittent porphyria
38
Dex Pros
Reduces MAC of inhaled agents, reduces postoperative opioid requirements
39
Which of the intravenous induction agents has a direct vasoconstriction effect on cerebral blood vessels?
Sodium Pentothal
40
The initial recovery from intravenous induction agents is due to:
Redistribution
41
Increases CmRO2?
ketamine
42
Barbiturate activation of the GABAA Receptor does what to the Cl- channel?
increases the duration of time the Cl- channel is open
43
Increases CBF, CPP, and ICP
ketamine
44
should be avoided in patients with a phenol allergy?
propofol