IV Anesthetics

Question 1

Propofol MOA

Answer 1

GABA(A) agonist

Question 2

Propofol Infusion Sedation

Answer 2

25-100 mcg/kg/min

Question 3

Propofol Infusion TIVA

Answer 3

100-300 mcg/kg/min

Question 4

Propofol Induction Dose

Answer 4

1. 5-2.5 mg/kg -Adults

2. 5-3.5 mg/kg -Peds

Question 5

Etomidate MOA

Answer 5

GABA(A) modulation

Question 6

Etomidate Induction Dose

Answer 6

0.2-0.4 mg/kg

Question 7

Ketamine MOA

Answer 7

NMDA Antagonist

Question 8

Ketamine Induction Dose

Answer 8

1-3 mg/kg IV

4-8 mg/kg IM

Question 9

Ketamine as an adjunct analgesic

Answer 9

0.2-0.5 mg/kg

Question 10

Ketamine Infusion

Answer 10

2-15 mcg/kg/min

Question 11

Dex MOA

Answer 11

alpha 2 agonist

Question 12

Dex premed dose

Answer 12

0.33-0.67 mcg/kg 15 minutes before surgery

Question 13

Dex MAC dosing

Answer 13

1 mcg/kg over 10 minutes and then 0.7 mcg/kg/min keeps BIS 70-80

Question 14

Barbituates MOA

Answer 14

GABA(A) agonist

Question 15

Benzodiazepine MOA

Answer 15

GABA(A) agonist

Question 16

Midazolam Dose

Answer 16

0. 5-4 mg IV - Adults
   - often 2mg bc that is what is in a vial

0.1-0.2 mg/kg IV -Peds

Question 17

Diazepam dose

Answer 17

5-10 mg IV -Adults

0.2-0.3 mg/kg IV -Peds

Question 18

Lorazepam PO pre-med dose

Answer 18

0.5-2.0 mg at HS and 0.5-2.0 mg PO at 0600

Question 19

Thiopental induction dose

Answer 19

3-5 mg/kg

Question 20

Methohexital induction dose

Answer 20

1-1.5 mg/kg

Question 21

Lorazepam dosing for amnesia

Answer 21

50 mcg/kg (max 4 mg) amnesia for 6 hours

Question 22

IV anesthetic that preserves CV function

Answer 22

Etomidate

Question 23

Most Common IV anesthetic

Answer 23

Propofol

Question 24

May cause R on T and Torsades

Answer 24

Droperidol

Question 25

Antiemetics that cause sedation

Answer 25

Droperidol

Scopolamine

Question 26

IV Anesthetics that cause pain at the injection site

Answer 26

Propofol

Etomidate

Question 27

Cons to Ketamine

Answer 27

dysphoria, hallucinations, emergence delirium

increases BP, HR, ICP, CBF, CMRO2 (don’t use in neuro cases)

Question 28

Amnestics

Answer 28

Benzos: Midazolam, Diazepam, Lorazepam

Question 29

Hypnotics

Answer 29

Sodium Thiopental, Propofol, Etomidate

Question 30

Analgesics

Answer 30

Opioids: Morphine, Meperidine, Fentanyl, Alfentanyl, Sufentanil, Remifentanil

Question 31

Anxiolytics

Answer 31

Propofol
Barbiturates (NaPentothal, Methohexital, Thiamylal)
Etomidate 
Ketamine
Benzos (Diazepam, Midazolam, Lorazepam)
Opioids

Question 32

Paralytics

Answer 32

Succinylcholine, Mivacurium, Rocuronium, Cisatracurium, Vecuronium, Pancuronium, Curare

Question 33

Flumazenil

Answer 33

BZD reversal (competitive antagonist)

Question 34

Propofol decreases PONV (T/F)

Answer 34

True

Question 35

Propofol Infusion Syndrom

Answer 35

(PRIS) is a life-threatening condition characterized by acute refractory bradycardia progressing to asystole and one or more of: metabolic acidosis. rhabdomyolysis. hyperlipidemia. enlarged or fatty liver.

Typically with longer infusions and higher doses

Question 36

Etomidate Cons

Answer 36

causes myoclonus
increases PONV
provides no analgesia
adrenal suppression

Question 37

Barbiturates Cons

Answer 37

May cause hyperalgesia, can cause histamine release, Extravasation causes tissue sloughing, do not mix with succ (will make “concrete”), intraarterial injection causes severe vasoconstriction, induces the P450 system, contraindicated in patients with acute intermittent porphyria

Question 38

Dex Pros

Answer 38

Reduces MAC of inhaled agents, reduces postoperative opioid requirements

Question 39

Which of the intravenous induction agents has a direct vasoconstriction effect on cerebral blood vessels?

Answer 39

Sodium Pentothal

Question 40

The initial recovery from intravenous induction agents is due to:

Answer 40

Redistribution

Question 41

Increases CmRO2?

Answer 41

ketamine

Question 42

Barbiturate activation of the GABAA Receptor does what to the Cl- channel?

Answer 42

increases the duration of time the Cl- channel is open

Question 43

Increases CBF, CPP, and ICP

Answer 43

ketamine

Question 44

should be avoided in patients with a phenol allergy?

Answer 44

propofol