NK Cells podcast

Question 1

Name three granulocytes

Innate or adaptive immunity?

Answer 1

Eosinophil
Basophil
Mast Cell

Innate immunity

Question 2

_____, ______ —-> _____, and _____ are phagocytes/ antigen presenting cells

Are they innate or adaptive immunity?

Answer 2

Neutrophils, Monocytes—> Macrophages, Dendritic cells

Innate

Question 3

name the lymphocytes
_____
_____
_____

____—> _____

Answer 3

T Helper, Cytotoxic T Cell, Regulatory T Cell, and B cell—-> plasma cel

Question 4

Natural Killer Cells (NK cells) are considered a lymphocyte given it’s morphological similarity to T helper cells (Th), Cytotoxic T Cells (CTLs) and B cells.
Like Th cells, they have the ability to produce _____ and they use ____ and ____
Innate or adaptive?
Is activity dependent on previous antigen exposure?

Answer 4

Interferon gamma (IFNy), perforin, granzyme
Innate
no, dependent on activating receptors that are germline encoded

Question 5

Definition: NK Cells
A class of \_\_\_\_\_\_ that recognize \_\_\_\_\_\_ and respond by \_\_\_\_\_ these cells and secreting \_\_\_\_\_

Macrophages with phagocytosed microbes secrete ___ to signal NK cells to secrete ____

Answer 5

Lymphocytes, infected and stressed cells, killing, macrophage-activating cytokine IFNy

Interleukin 12 (IL-12)

Question 6

Immunophenotype:

NK cells express ___ and ____

Answer 6

CD16 and CD56

Question 7

Activation of NK cells

recognize ____ to inhibit cell killing

Answer 7

MHC 1

If MHC1 is not present due to infection, then NK cell is activated and kills

Question 8

Effector Molecules: Use ___ and ____ to kill target cells

Target cells include:

Explain ADCC (Antibody-dependent cellular cytotoxicity)

Answer 8

granzyme and perforin. taken in by receptor mediated endocytosis—> activation of apoptotic pathways

Virus cells and tumor cells

IgG antibody coated cell is detected by NK cell Fcy receptor, NK cells are activated and kill antibody-coated cells.