Nitrogen Metabolism Flashcards
Humans have no storage form of ______.
Nitrogen
Nitrogen itself is a ________ compound, so the body must get rid of any excess above the needs of the body.
Reactive
Most nitrogen will leave the body via the _______ _______, which serves to clear the body of excess nitrogen, but also retains any “carbon skeletons” of the nitrogen containing compounds for other uses.
Urea Cycle
Most nitrogen enters the body in the form of ____ _____.
Amino acids
_____ out of 20 amino acids can be synthesized de novo.
10 to 11
The Urea Cycle only occurs in cells located in the ________.
Liver
True or False:
The amino acid pool of the body is in a steady state
True
Protein Turnover in the Body:
Individual proteins have distinctive half-lives that are either short-lived or long-lived. Most proteins will lie where in terms of half-life?
Somewhere in the middle between these 2.
True/False:
Proteins that are misfolded or unstable are degraded more slowly than their normal counterparts.
FALSE
Unstable proteins are degraded more RAPIDLY.
This specific amino acid sequence targets proteins for rapid degradation…
PEST
Proline-glutamate-serine-threonine
Lysosomal degradation is _________.
Selective or non-selective?
Non-selective.
Proteasomes will __________ degrade proteins. (Selectively/non-selectively?)
Selectively
