nitpicky micro

Question 1

What is the virulence factor of diphtheria?

Answer 1

A toxin with an A and B domain. The A domain will transfer an ADP-ribose to EF2 which stops protein synthesis

Question 2

What is the virulence factor in Shigella?

Answer 2

Shiga toxin: cleaves a base from the 60S ribosome and leads to cell death

Question 3

What is the virulence factor of strep pyogenes?

Answer 3

M factor: inhibits Ab binding and completment derived opsonization, protects the organism against phagocytosis

Question 4

A sheep farmer who recently moved to US from South america presents with a headache, vomiting, and changes in speech. What is the diagnosis and treatment for this patient?

Answer 4

Echinococcus granulosus: comes from dogs, sheep, whatever

Treat with albendazole

Question 5

What is the MOA of albendazole- used in several fungal infections.

Answer 5

Inhibits the microtubule formation by binding to beta tubulin

Inhibits mitochondrial fumarate reductase, reduces glucose transport, uncouples oxidative phosphorylation

Question 6

What are the opportunistic infections? 
Fungi
Protozoa 
Viruses 
Encapsulated bacteria

Answer 6

Fungi: pneumocystitis jirovecii

Protozoa: Cryptosporidium

Viruses: CMV

Encapsulated bacteria: Strep pneumo

Question 7

What are the catalase positive organisms?

cats have BeeN PLACES

Answer 7

Burkholderia 
Nocardia 
Pasteurella 
Listeria 
ASpergillus 
Candida 
E Coli 
Staphylococcus 
Serratia

Question 8

_______ is another more common name for variola

Answer 8

Smallpox

Question 9

RAPID symptoms after food exposure cause?

Answer 9

Staph aureus probs

happens like 2-6 hours after exposure

Usually picnics… picnics are bad