HIGH YIELD DIRTY MEDICINE PHARM and mine Flashcards
What are the HTN drugs that are used in pregnancy?
Hydralazine
Methyldopa
Labetalol
Nifedipine
Hypertensive Moms Love Nifedipine
Patient needs an NSAID but has gastric ulcers… you give them?
Celecoxib: COX2 inhibitor
Patient has Heparin Induced Thrombocytopenia- what do you do?
- STOP heparin
2. Give a direct thrombin inhibitor: Agatroban
What do you do if a patient needs furosemide but has a sulfa allergy?
Give them Ethacrynic Acid
What are the two highest yield drugs that cause gynecomastia?
Spironolactone
Ketoconazole
If someone is taking spironolactone and has gynecomastia, what other drug can you give them?
Eplerenone
What diuretics cause HYPERcalcemia?
Thiazides
***can also cause hyperuricemia and worsen gout
What diuretics cause HYPOcalcemia?
Loop diuretics:
LOOPS LOSE
***can cause ototoxicity
What drugs can cause ototoxicity?
Aminoglycoside (mycin: bind 30S)
Loops
Cisplatin: used for ovarian and testicular tumors
ASA
Which drugs are nephrotoxic?
Aminoclycosides (mycin: bind 30S) Amphotericin B (amphoTERRIBLE)
What drugs can cause dilated cardiomyopathy?
Alcohol
Doxorubicin/Danorubicin: treat the patient with dexrazoxane
A patient comes in with orange body secretions, what drug are they on?
Rifampin: TB tx
Which drug is associated with red man Syndrome?
Vancomycin
Which drug is associated with grey baby syndrome?
Chloramphenicol
Which drug causes agranulocytosis?
Clozapine
Monitor CBC CLOZly !
What drugs can cause drug induced lupus? (anti-Histone)
Hydralazine Isoniazid Procainamine Methyldopa Quinidine
What drug can cause hemorrhagic cystitis?
Cyclophosphamide
TREAT WITH MESNA
What drug can cause cartilage damage in kids?
Fluoroquinolones
What drugs can cause bone or tooth damage to kids or pregnant patients?
Tetracyclines
What drugs can cause prolonged QT syndrome?
Azithromycin
Class 1a
Class 1c
Class III
***all these drugs effect the potassium current
What drugs can cause hemolysis in a G6P deficiency?
Quinidine
Sulfonamides
Isoniazid
What are the side effects of the TB drugs
RIPE ON GO
Rifampin: Orange secretions
Isoniazid: Neuropathy, B6 deficiency, Drug SLE, hemolysis
Pyrazinamide: Gout
Ethambutol: Optic Neuritis
What is the MOA of metformin?
Decreases hepatic gluconeogensis via inhibition of the mitochondrial glycerophosphate dehydrogenase
If Lithium is given during pregnancy, what is one of the major cardiovascular effects?
Ebstein anomaly: Tricuspid valves are apically displaced and causes an enlargement of the R atrium.
_______ is a second generation anti-psychotic that can cause agranulocytosis (decreased WBCs specifically neutrophils)
Clozapine
What are some adverse effects of amphotericin B?
Nephrotoxicity Renal Tubular Acidosis arrhythmias Anemia Hypotension fever, chills, vomting
What are the first and second medications that are given for a cholinesterase inhibitor poisoning?
Atropine first then pralidoxamine
What is the mechanism of rifampin?
inhibition of DNA dependent RNA polymerase
What recombinant cytokine can be used to treat MS?
B interferon
What is the MOA of triptans?
5HT agonist
What do you treat the plague with?
Streptomycin
