HIGH YIELD DIRTY MEDICINE PHARM and mine

Question 1

What are the HTN drugs that are used in pregnancy?

Answer 1

Hydralazine
Methyldopa
Labetalol
Nifedipine

Hypertensive Moms Love Nifedipine

Question 2

Patient needs an NSAID but has gastric ulcers… you give them?

Answer 2

Celecoxib: COX2 inhibitor

Question 3

Patient has Heparin Induced Thrombocytopenia- what do you do?

Answer 3

1. STOP heparin

2. Give a direct thrombin inhibitor: Agatroban

Question 4

What do you do if a patient needs furosemide but has a sulfa allergy?

Answer 4

Give them Ethacrynic Acid

Question 5

What are the two highest yield drugs that cause gynecomastia?

Answer 5

Spironolactone

Ketoconazole

Question 6

If someone is taking spironolactone and has gynecomastia, what other drug can you give them?

Answer 6

Eplerenone

Question 7

What diuretics cause HYPERcalcemia?

Answer 7

Thiazides

***can also cause hyperuricemia and worsen gout

Question 8

What diuretics cause HYPOcalcemia?

Answer 8

Loop diuretics:

LOOPS LOSE

***can cause ototoxicity

Question 9

What drugs can cause ototoxicity?

Answer 9

Aminoglycoside (mycin: bind 30S)
Loops
Cisplatin: used for ovarian and testicular tumors
ASA

Question 10

Which drugs are nephrotoxic?

Answer 10

Aminoclycosides (mycin: bind 30S) 
Amphotericin B (amphoTERRIBLE)

Question 11

What drugs can cause dilated cardiomyopathy?

Answer 11

Alcohol

Doxorubicin/Danorubicin: treat the patient with dexrazoxane

Question 12

A patient comes in with orange body secretions, what drug are they on?

Answer 12

Rifampin: TB tx

Question 13

Which drug is associated with red man Syndrome?

Answer 13

Vancomycin

Question 14

Which drug is associated with grey baby syndrome?

Answer 14

Chloramphenicol

Question 15

Which drug causes agranulocytosis?

Answer 15

Clozapine

Monitor CBC CLOZly !

Question 16

What drugs can cause drug induced lupus? (anti-Histone)

Answer 16

Hydralazine 
Isoniazid 
Procainamine 
Methyldopa 
Quinidine

Question 17

What drug can cause hemorrhagic cystitis?

Answer 17

Cyclophosphamide

TREAT WITH MESNA

Question 18

What drug can cause cartilage damage in kids?

Answer 18

Fluoroquinolones

Question 19

What drugs can cause bone or tooth damage to kids or pregnant patients?

Answer 19

Tetracyclines

Question 20

What drugs can cause prolonged QT syndrome?

Answer 20

Azithromycin
Class 1a
Class 1c
Class III

***all these drugs effect the potassium current

Question 21

What drugs can cause hemolysis in a G6P deficiency?

Answer 21

Quinidine
Sulfonamides
Isoniazid

Question 22

What are the side effects of the TB drugs

Answer 22

RIPE ON GO

Rifampin: Orange secretions

Isoniazid: Neuropathy, B6 deficiency, Drug SLE, hemolysis

Pyrazinamide: Gout

Ethambutol: Optic Neuritis

Question 23

What is the MOA of metformin?

Answer 23

Decreases hepatic gluconeogensis via inhibition of the mitochondrial glycerophosphate dehydrogenase

Question 24

If Lithium is given during pregnancy, what is one of the major cardiovascular effects?

Answer 24

Ebstein anomaly: Tricuspid valves are apically displaced and causes an enlargement of the R atrium.

Question 25

_______ is a second generation anti-psychotic that can cause agranulocytosis (decreased WBCs specifically neutrophils)

Answer 25

Clozapine

Question 26

What are some adverse effects of amphotericin B?

Answer 26

Nephrotoxicity 
Renal Tubular Acidosis 
arrhythmias 
Anemia 
Hypotension 
fever, chills, vomting

Question 27

What are the first and second medications that are given for a cholinesterase inhibitor poisoning?

Answer 27

Atropine first then pralidoxamine

Question 28

What is the mechanism of rifampin?

Answer 28

inhibition of DNA dependent RNA polymerase

Question 29

What recombinant cytokine can be used to treat MS?

Answer 29

B interferon

Question 30

What is the MOA of triptans?

Answer 30

5HT agonist

Question 31

What do you treat the plague with?

Answer 31

Streptomycin