Nifedipine (Calcium Channel Blocker - Dihydropyridine Type)

Question 1

Expected Pharmacological Action:

Answer 1

Inhibits calcium influx into vascular smooth muscle, causing vasodilation and reduced blood pressure.

Question 2

Therapeutic Use:

Answer 2

Hypertension
Angina
Raynaud’s phenomenon

Question 3

Complications:

Answer 3

Reflex tachycardia
Peripheral edema
Dizziness & headache
Flushing

Question 4

Contraindications/Precautions:

Answer 4

Severe hypotension
Heart failure (use caution)
Recent myocardial infarction
Hypersensitive

Question 5

Interactions:

Answer 5

Grapefruit juice → increases drug levels
Beta-blockers → increased risk of heart failure and bradycardia
Digoxin
Fentanyl
Phenytoin

Question 6

Client Education:

Answer 6

Avoid grapefruit juice
Monitor for swelling in legs/ankles
Do not crush extended-release tablets
Avoid hot tubs & prolonged sun exposure

Question 7

Dosage:

Answer 7

Hypertension: 30–90 mg daily