Next to Last Day Flashcards

1
Q

Antiphospholipid Antibodies?

A

-family of autoantibodies directed against phospholipid binding plasma protein (beta-glycoprotein)

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2
Q

Clinical Manifestations of antiphospholipid syndrome?

A
  • asymptomatic to catastrophic antiphospholipid syndrome
  • have positive aPL
  • to prevent secondary thrombosis its risk-stratified, give high intensity anticoaguation in APS patients
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3
Q

Most common presentation of antiphospholipid syndrome?

A
  • arterial thrombosis-stroke

- vein manifestation-deep vein thrombosis

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4
Q

Side effects of Antiphospholipid Syndrome?

A
  • pregnancy loss after 10 weeks gestation

- to prevent fetal loss give low-dose aspirin and heparin

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5
Q

Catastrophis APS

A

-multiple thromboses of small/medium arteries over days

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6
Q

-

A

-

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7
Q

Pathogenesis of SLE

A
  • ongoing autoimmune reactions-autoantibodies/other protein products
  • complement deficiencies confer highest risk (mutation in TREX1)
  • environmental: UV light
  • Type I INF-immune activation (key player)
  • platelets/neutrophils/complement
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8
Q

Organ Systems affected by SLE

A

RASH PAIN O MD

  • renal
  • arthritis
  • serositis
  • hematologic
  • photosensitivity
  • ANA positive
  • immunologic
  • neurologic
  • oral rash
  • discoid rash

Must have 4 of these

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9
Q

Clinical Features of Sjogren’s Syndrome?

A

-deratoconjunctivitis sicca (dry eyes)
-xerostomia (dry mouth)
-parotid gland swelling
44X increase for non-hodgkin’s lymphoma
Pulmonary,renal,neuromuscular, raynauds, arthralgias

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10
Q

How is Sjogren’s Syndrome Diagnosed?

A
  • subjective/objective assessment of dry eyes, dry mouth
  • test: anticuclear abs, anti-Ro/SSA, antiLa/SSB
  • salivary gland biopsy
  • Schirmer’s test
  • ANA
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11
Q

Lupus symptoms

A

Jaccoud’s arthropathy - joint not eroded
Serositis-pleura, pericardium, peritoneal cavity
-chest pain, alveolar hemorrhage
-shrinking lung syndrome
Kidney Involvement-anti-DNA-ab
Raynodes - vascular loss to fingers

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12
Q

Mixed Connective Tissue Disease

A
  • lupus, scleroderma, inflammatory myositis
  • **Raynaud’s
  • U1-RNP antibodies (lack of renal/CNS)
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13
Q

Major cause of death in Mixed Connective Tissue Disease?

A

pulmonary hypertension (give EKG)

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14
Q

Undifferentiated Connective Tissue Disease

A
  • Raynodes
  • nail-fold capillary microscopy
  • U1-RNP - MCTD
  • DNA ab - SLE
  • nuclear-SSc
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