Neurotransmitters

Question 0

What type of reaction forms L-Dopa from tyrosine?

Answer 0

Hydroxylation

Question 1

What is the immediate precursor of thyroxine and L-Dopa?

Answer 1

Tyrosine

Question 2

What are the 2 cofactors for transforming tyrosine to L-dopa?

Answer 2

Tetrahydrobiopterin and NADPH

Question 3

In the synthesis of catecholamines, what is the rate limiting step?

Answer 3

Tyrosine to L-Dopa

Question 4

Aromatic hydrocarbon decarboxylase is an enzyme for what?

Answer 4

Synthesis of dopamine

Question 5

What cofactor is required in the synthesis of dopamine?

Answer 5

Pyridoxal phosphate (PLP)

Question 6

What enzyme of responsible for formation of norepinephrine?

Answer 6

Dopamine beta-hydroxylase

Question 7

What cofactors are required for formation of NE? (3)

Answer 7

Cu2+, Vit C, O2

Question 8

Phenylethanolamine N-methyltransferase is an enzyme for what?

Answer 8

Formation of epinephrine

Question 9

Phenylethanolamine N-methyltransferase synthesis is induced and inhibited by what?

Answer 9

Glucocorticoids; Epi

Question 10

The synthesis of creatine begins with what?

Answer 10

2 amino acids

Question 11

What is creatine subject to?

Answer 11

Reversible phosphorylation

Question 12

What purpose does creatine serve?

Answer 12

High energy storage form

Question 13

Excretion of what is constant and related to muscle mass?

Answer 13

Creatinine

Question 14

Why is creatinine used as an indicator of kidney function?

Answer 14

Because it is cleared very efficiently

Question 15

Tyrosine hydroxylase has two forms. What makes the form that produces melanins different?

Answer 15

It is Cu dependent

Question 16

Is tyrosine essential?

Answer 16

No, not as long as phenylalanine is present

Question 17

What are the two locations of the tyrosine to Epi pathway?

Answer 17

In neurons and adrenal medulla