Fatty Acid Synthesis Flashcards
Fatty acids are made from what?
Glucose
Fatty acids are the preferred fuel for which organ?
The heart
Fatty acids are stored in … and synthesized in …
adipose, liver
Where are the enzymes for FA synthesis located?
in the cytosol
Where does NADPH come from for FA synthesis?
Pentose pathway and malic enzyme
How many ATP are required to start FA synthesis?
2
What are the 4 repeated steps for FA synthesis?
condensation, reduction, dehydration, reduction
What is the carrier of FFA in the general circulation?
albumin
Where does FA synthesis occur in the cell?
cytosol
What is the key regulatory enzyme of FA synthesis?
acetyl CoA carboxylase
What vitamin does acetyl CoA carboxylase require?
Biotin
What are the key inhibitors of FA synthesis?
palmitoyl CoA, glucagon
A (high/low) fat diet induces FA synthesis
low
What two dietary elements decrease FA synthesis?
high-fat diet, fasting
Fatty acids synthesized in the … are converted to …, packaged in …, and secreted into the blood.
liver; triglycerides; VLDL
palmitate can be elongated by 2 carbons to form what?
stearic acid
Palmitate can be oxidized to form what?
palmitoleic acid
Palmitate can be activated by … to form …
Acytl CoA; palmitic acid
Palmitate can be activated by … to form …
Acytl CoA; palmitic acid
Why can’t adipose tissue use glycerol?
Lacks glycerol kinase
