Neurotoxicity Flashcards
1
Q
Mechanism of action of orrganophosphate compounds
A
Inhibition of enzyme acetylcholinerase
2
Q
Organophosphorus compounds are originally designed to be _______
A
chemical warfare agent
3
Q
Antidotes of acute organophosphorus poisoning
A
Atropine, Pralidoxime
4
Q
Treatment of lead toxixity
A
Chelation: Ca-diNA-EDTA, Dimercapol (BAL)
Oral: Penicillamine
5
Q
Spore forming, gram positive, anaerobic bacteria
A
Clostidium Botulinum
6
Q
Signs and symptoms of botulism
A
Inhibition of skeletal muscle innervation Flaccid muscular paralysis Blurred vision Difficulty swallowing Respiratory paralysis (cause of death）
7
Q
Structure of botulinum toxin
A
two polypeptide chains
subunit A: 100kDa heavy chain [active component]
subunit B: 50kDa light chain [binding part]
8
Q
Which does botulinum toxin binds?
A
Presynaptic membrane of motor neuron nerve terminals
