General Principle Flashcards
Study of effect of drugs on the function of living systems
Pharmacology
Study the effect of ‘poison’ on the function of living system
Toxicology
Any strange substances to our body
Xenobiotic
Chemical/ Physical agent that can cause toxicity when in high doses
Toxic agent
Chemical/ Physical agent that can produce toxicity even in low doses
Poison
Toxic compound produced by biological systems
Toxin
When a compound reaches values above safe maximum dose
Intoxication
Constellation of toxic effects
Toxic syndrome
Relationship of an individual test subject or system to increasing and/ or continuous doses of a chemical
Graded dose response
Determined by the distribution of responses to increasing doses in a population of test subjects or systems
Quantal dose response
The concentration can cause 50% of tested individual to have toxic effect
Toxic Dose (TD50)
concentration necessary to inhibit 50% of measured response in an in vitro system
Inhibitory Concentration (IC50)
Antidote:
Acetaminophen
Acetylcysteine
Antidote:
Acetylcholinesterase Inhibitors
Atropine
Antidote:
Iron salts
Deferoxamine