Neuropsychology Flashcards
Test test
What are the main categories of antidepressant?
TCAs, SSRIs, and MAOIs
What does TCA stand for?
“Tricyclic Antidepressants”
One of the three main categories of antidepressant, along with SSRIs and MAOIs
What class of antidepressants works by blocking the uptake of Serotonin and Norepinephrine?
TCAs
Fit with the catecholamine hypothesis
What hypothesis may explain the effects of TCAs?
The catecholamine hypothesis
What Hypothesis says that depression is caused specifically by low levels Norepinephrine?
The catecholamine hypothesis
What does the catecholamine hypothesis state?
That depression is caused specifically by low levels of norepinephrine
May explain the effectiveness of TCAs
In what two ways are TCAs generally less safe than SSRIs?
TCAs generally have
1) a higher toxicity (easier to overdose on), and
2) worse side effects
Why must TCAs be prescribed with caution for individuals who have heart disease or are suicidal?
They have potential cardiovascular side effects and are highly toxic in overdose
They generally have 1) a higher toxicity, and 2) worse side effects
How TCAs are generally less safe than SSRIs
Which two classes of antidepressant are used for mainstream depression cases?
TCAs and SSRIs
Which class of antidepressant is used for atypical depression cases?
MAOIs
What does MAOI stand for?
“Monoamine Oxidase Inhibitors”
What three symptoms of depression are TCAs especially effective for?
Hopelessness Anhedonia Physical symptoms
What Hypothesis says that depression is caused by low levels of both Norepinephrine and Serotonin?
The permissive hypothesis
What does the Permissive Hypothesis state?
That depression is caused by low levels of both Norepinephrine and Serotonin
How does the Permissive Hypothesis differ from the Catecholamine Hypothesis?
Permissive: depression is caused by low levels of both Norepinephrine and Serotonin Catecholamine: depression is caused specifically by low levels of Norepinephrine
Which Neurotransmitter is associated with ADHD?
Dopamine
Why is the Catecholamine Hypothesis associated with TCAs?
Because TSAs uniquely target Norepinephrine It also targets Serotonin (which would support the Permissive Hypothesis), but SSRIs target Serotonin too
What Neurotransmitter is associated with Schizophrenia?
Dopamine i.e. the Dopamine hypothesis
What hypothesis is the basis of second-generation antipsychotics?
That schizophrenia is caused by an imbalance between dopamine and norepinephrine levels
As opposed to the Dopamine hypothesis, which focuses only on the former
What neurotransmitter is associated with both depression and chornic pain?
Norepinephrine
Who should TCA’S not be prescribed for?
People who have heart disease or people who are suicidal.
What drug is prescribed for enuresis?
Imipramine (TCA)
What specific drug is used to treat OCD?
Clomipramine (TCA)
Which of the three classes of antidepressants treats premature ejaculation?
SSRI’s
What type of antidepressant does not have anticholinergic effects?
SSRI’s
confusion and memory impairment in older adults is a side effect of which antidepressant?
TCA’S
Examples of Anticholinergic side effects
dry mouth
constipation
urinary retention
blurred vision
TCA drug names typically end in…
“amines”
“tryptalines”
Three TCA drugs
Imipramine
Clomipramine
Amitriptyline
SSRI’s uniquely treat these three disorders
Social Phobia
Binge eating
Premature Ejaculation
Within the antidepressant categories
TCA’s uniqely treats these three disorders…
Enuresis (imipramine)
Agoraphobia
Chronic Pain
conduction apashia is caused by…
damage to nerve fibers (arcuate fasciculus) that connect Wernicke’s area to Broca’s
Anomia is
inability to recall the names of familiar objects
(common with damage to Broca’s area or damage to the arcuate fasciculus)
A person with conduction aphasia can and cannot
can comprehend language and speak fluently
cannot repeat what they have heard and has anomia
Difficulties repeating what they have just heard is related to these areas of the brain…
Broca’s area and arcuate fasciculus (conduction aphasia)
Research has identified brain abnormalities for OCD, Tourettes, ASD in these two brain areas
frontal lobes and basal ganglia
Exposure and Response Prevention is treatment for these anxiety related behaviors…
Specific Phobia,
Social Phobia,
Panic Disorder,
Agoraphobia,
Social Anxiety,
OCD,
Agoraphobia vs. Specific Phobia
Fear of not being able to escape vs. fear of the thing or situation itself
Systematic desensitization is treatment for
young children with separation anxiety
CBT used for treatment of
seperation anxiety for older children
GAD
Panic Disorder (via panic control therapy)
polythetic criteria
What the DSM-5 uses; Means you can have many but not all properties of a disorder to meet criteria
OCD prevalence in children by gender
higher in males than female children
peak onset is age 6 to 15 in males
OCD higher in males or female children?
Males; they have an earlier onset (age 6-15)
For females peak onset of OCD is
age 20 to 29
OCD prevalence rate is ______ among adult males and females
equal
Percentage of women who experience baby blues after pregnancy?
50-80%
Percentage of women who experience post partum depression?
10-20%
Insulin is released by the
pancreas
Hypoinsulin causes
diabetes mellitus (excessive blood glucose)
Diabetus mellitus symptoms included
- increased appetite with weight loss
- confusion and mental dullness
- susceptibility to infection
Cushing’s disease symptoms include
- emotional lability
- memory loss
- depression
- obesity
Cushing’s disease is caused by…
secretion of too much cortisol
Hyperthyrodism can mimic these psychogenic symptoms
Hormones
mimic anxiety and hypomania
Hyperthyroidsim (grave’s disease) is characterized by…
- accelerated heart
- agitation and nervousness
- fatigue and insomnia
- elevated body temp and heat intolerance
- increased appetite with weight loss
Hypothyroidism is characterized by…
- Slowed heart rate
- depression, lethargy, decreased libido
- impaired concentration and memory
- reduced appetite and weight gain
- lowered body temp
Adolescent-onset is when a teen has no symptoms of CD before the age of _____?
10 years old
Schizophrenia brain abnormalities involve the…
increased volume lateral and third ventricles
smaller amgydala and hippocampus
hypofrontality
ADHD brain abnormalities involve the…
PFC
Cerebellum
Caudate nucleus
Putamen
ASD brain abnormalities involve the…
cerebellum
corpus collossum
amygdala
“Recent” memories vs. remote memories in retrograde amnesia
Remote memories are intact while recent memories of learned information are not
Anterograde amnesia is the ability to remember
newly learned information
Thiamine deficiency
Common in Korsakoff’s syndrome; cause anterograde retrograde (recently learned info) amnesia
syn. is Alcohol-Induced Neurocognitive Disorder
Damage to the temporal lobe causes…
severe anterograde amnesia,
auditory perception (not understanding what someone says),
changes in sexuality,
benzodiazepines end in …
“pam” (ex diazepam)
used to treat anxiety disorders
Medications considered most effective at treating OCD
TCA’s and SSRI’s
Treatment for Parkinson’s disease involves medication that does what to involved neurotransmitters?
block excess acetylcholine
increase levels of dopamine
Parkinson’s disease is caused by
loss of dopamine in the substantia nigra
Before symptoms are present, Huntingtons disease can be idenitified by
MRI; reduced basal ganglia volume
PET scan of reduced metabolic activity
Weber’s Law
Just noticeable difference is porportional to orginal stimulus
Fechner’s law
Logarithmic relationship between psychological sensation and magnitude of physical sensation
more accurate then Weber’s law for extreme intensities
Steven’s power law
There is a exponential relationship between psychological sensation and mag. of physical stimulus AND exponent varies based on different stimuli
Second line treatment for ADHD
imipramine (TCA)
apraxia
inability to execute purposeful movement
caused by damage to frontal or parietal lobes
akathesia
motor restlessness and inability to sit still
aphasia
deficit in using or understanding language
agnosia
???
anomia
inability to recall the names of familiar objects
ataxia
incoordination accompanied by slurred speech
Frontal lobe damage is characterized by…
deficits attention, concrete thinking, free recall,
perseveration and stereotypy,
personality changes,
issues with arithmetic
Partial seizures commonly occur in which part of the brain?
Temporal lobe
Petit mal (absence seizures) occur in which part of the brain?
Thalamus (relay center for the brain)
Damage to the Broca’s area results in…
expressing language
repeating what was said