Diagnosis And Psychopathology Flashcards
What DSM-5 term refers to a diagnosis will eventually be met but not sufficient info for firm diagnosis
“Provisional”
What does the term “provisional” mean in the DSM-5?
That a diagnosis will eventually be met but not sufficient info for firm diagnosis
What DSM-5 term allows the clinition to indicate why the symptoms do not met the full diagnosis criteria?
“Other-specified”
What does the term “Other-specified” mean in the DSM-5?
It allows the clinition to indicate why the symptoms do not met the full diagnosis criteria
What DSM-5 term allows the clinician to indicate that symptoms don’t meet criteria when they do not want to say why?
“Unspecified”
What does the term “unspecified” mean in the DSM-5?
That symptoms don’t meet criteria and clinician does not want to say why
- deficit in intellectual functioning
- deficits in adaptive functioning across multiple settings in 1 or more activities of daily living
- onset during early developmental period
The diagnosis crtieria for an Intellectual Disability
What are the diagnosis crtieria for an Intellectual Disability?
- deficit in intellectual functioning
- deficits in adaptive functioning across multiple settings in 1 or more activities of daily living
- onset during early developmental period
The two basic diagnostic criteria that Autism Spectrum Disorder lies at the intersection of
- Full criteria:*
- impairments in social communication*
- Restricted, repetitive behavior patterns, interests, and activities*
- Onset during EARLY developmental period*
- Symptoms cause impaired functioning*
- impairments in social communication
- Restricted, repetitive behavior patterns, interests, and activities
- Onset during EARLY developmental period
- Symptoms cause impaired functioning
The diagnostic criteria for Autism Spectrum Disorder
What are the diagnostic criteria for Autism Spectrum Disorder?
- impairments in social communication
- Restricted, repetitive behavior patterns, interests, and activities
- Onset during EARLY developmental period
- Symptoms cause impaired functioning
Intellectual Disability etiology
30% due to chromosomal abnormalities (Down Syndrome)
5% due to hereditary (Tay-Sach’s disease, PKU, fragile X syndrome)
10% pregnancy and perinatal complications (fetal malnutrtition, anoxia, HIV)
15-20% environmental factors and mental disorders (severe deprivation, autism)
30-40% of cases cause is unknown
What is the largest known etiological factor for ID?
Down Syndrome
Accounts for 30% of cases
What is the second-largest known etiological factor for ID?
Environmental factors and mental disorders (e.g., severe deprivation, autism)
(accounts for 15-20% of children with ID)
What percentage of ID is due to pregnancy or perinatal complications?
Ex. fetal malnutrition, anoxia, HIV
10% of ID cases are due to these factors
What percentage of ID is due to hereditary reasons?
(e.g., Tay-Sach’s, PKU, Fragile X syndrome)
5% of ID cases are due to these reasons
strongest predictor of ID
low birth weight
What are the early symptoms of Autism?
- Delay in lang. development (not speaking by 2) and abnormal communication (echolalia)
- Lack of social interest or unusual social interactions
- Unusual patterns of play (lining up toys)
Best prognosis for Autism will include
- Development of functional language by age 5
- IQ over 70
- later onset of symptoms
- absence of comorbid disorders
What is a major contributing etiological factor for Autism?
Genetics
(higher concordance between MO vs. DI twins)
Neurotransmitters associated with Autism
Serotonin and GABA
Autistic brain irregularities are found in the…
amygdala and cerebellum
Best Autism Treatment?
Early intensive behavioral intervention in the home setting before age 5
ADHD definition
Pattern of inattention and/or hyperactivity
that lasts at least six months
apparent in at least two settings
ADHD onset requirement
Before 12 years
ADHD symptom requirement (children; adults)
6 symptoms for less than 17 years
5 symptoms for 17+
ADHD Prevalence in children; adults
5% in children; 2.5% in adults
ADHD prevalence by gender (male:female)
____ in children
____ in adults
2: 1 in children
1. 6:1 in adults (male:female)
Behavioral experiences of hyperactivity and impulsivity in ADHD children vs. adults
Children more likely to experience hyperactivity;
Adults present as more inattentive
What four brain areas are theorized to be impacted by ADHD?
PFC
Cerebellum
Caudate Nucleus
Putamen
Behavioral Disinhibition Hypothesis describes ADHD as
an inability to adjust activity levels to the requirements of the situation.
How is ADHD treated?
combination of medication and behavioral intervention.
Central Nervous stimulants work on ___% of individuals.
80%
Specific Learning Disorder
Impairment in reading, written expression, math (lasting for six months), despite intervention
What percentage of children with SLD also have ADHD?
20-30% of children with SLD also have ADHD
SLD etiology
- Exposure to toxins
- Early malnutrition
- Hemispheric dominance (incomplete dominance or mixed laterality)
- Cerebellar-vestibular dysfunction (due to otitis media; inflammation in middle ear)
Childhood-Onset Fluency Disorder (colloquial term)
stuttering
Childhood-Onset Fluency Disorder
Impairment in fluency and time patterning of speech
Onset of stuttering (COFD) is between
2-7 years of age
Predictor of persistence in Childhood-onset Fluency Disorder?
severity of stuttering at age 8
COFD treatment
Habit Reversal Training
Stuttering increases alongside levels of
stress
What are the components of habit reversal training?
Awareness training
Competing response training (deep breathing)
Social support
Habit reversal training is a treatment for…
Stuttering.
(also–component of CBIT for Tics)
Criteria for Tourette’s Disorder
One vocal tic and multiple motor tics
When is the typical onset of Tourette’s disorder?
Between 4-6 years
What is the age of onset criteria for Tourette’s?
Before age 18
What is the criteria of duration for Tourette’s diagnosis?
at least 1 year
Tourette’s disorder is often comorbid with
OCD and ADHD
Medication management for Tourette’s with ADHD
Anti-hypertensive drugs (e.g., clonodine)
What is the criteria for duration in order to receive a diagnosis of Delusional Disorder?
Presence of one or more delusions for at least 1 month:
Erotomanic
Grandiose
Jealous
Persecutory
Somatic
Mixed
Unspecified
A person’s overall functioning (IS/IS NOT?) markedly impaired by the delusion in Delusional Disorder?
Is Not
Duration of symptoms required for a diagnosis of schizophrenia
signs of disorder for at least six months
active phase symptoms for at least a month
Active phase symptoms of schizophrenia include:
delusions
hallucinations
disorganized speech
disorganized behavior
negative symptoms (anhedonia, avolition)
At least one of the symptoms of schizophrenia must be:
delusions, hallucinations, or disorganized speech
Schizophrenia symptoms typically appear between
late teens and early 30’s
Peak age of first psychotic episode in schizophrenia occurs…
(early to mid 20’s)
Best prognosis for schizophrenia includes
- Late and acute onset
- Insight
- Brief duration of active phase
- Family history of mood disorder but no family history of schizophrenia
Which racial group have highest rates for schizophrenia?
African Americans; may be incorrect as AA’s have more delusions and hallucinations with MDD and Bipolar Disorder which could be misdiagnosed as Schizophrenia
Better prognosis for patients in developing countries
Schizophrenia
Brain-based etiology for Schizophrenia
- Increased volume in lateral and third ventricles
- Reduced size of hippocampus and amygdala
- Hypofrontality (LOW PFC) relates to negative symptoms
Neurotransmitter hypotheses for Schizophrenia
- Dopamine Hypothesis
- Imbalance in Norepinephrine and Dopamine levels (see second gen. antipsychotic meds)
Second-generation antipsychotic medications are based on the theory that…
Imbalance in Norepinephrine and dopamine levels
Dopamine hypothesis for Schizophrenia posits…
Elevated dopamine receptors or oversensitive dopamine receptors
Now expanded to include Norepinephrine, serotonin, and glutamate
Schizophrenia prevalence in general population
less than 1% of gen. pop.
Two highest schizophrenia prevalence is found in:
Monozygotic Twins: 48%
Child of 2 parents: 46%
Schizophrenia genetic concordance rates for dizygotic twins and biological siblings:
Dizygotic Twins: 17%
Bio Sibs: 10%
Schizophrenia genetic concordance rates for child of 1 parent with Schizophrenia is:
Child of 1 parent: 13%
Three first-generation drugs used to treat schizophrenia.
Chloropromazine
Thioridazine
Haloperiodol
Four second-generation antipsychotic drugs used to treat schizophrenia
Clozapine
Risperidone
Olanzapine
Ariprazole
Why are second-generation drugs for the first line of treatment for schizophrenia?
Targets both positive and negative symptoms; doesn’t cause tardive dyskinesia
First-generation only targets positive symptoms
Schizophreniform criteria for duration?
at least 1 month of active phase; continuous signs for less than 6 months
Schizophreniform vs. Schizophrenia
continuous signs of disorder for less than 6 months
impaired functioning not required
same symptom requirement
Brief Psychotic Disorder symptom duration
One day to less than one month
Brief Psychotic Disorder vs. Schizophreniform/Schizophrenia
Only one or more main symptoms required
Eventual return to premorbid function
onset follows stressful event
Schizoaffective disorder
- concurrent psychotic symptoms and major depressive or manic episode
- Period of 2 weeks or more with only psychotic symptoms w/o mood symptoms
Schizophrenia vs. Schizophreniform vs. Brief Psychotic Disorder
Schizophrenia
- 2 or more symptoms, with at least one core symptom
- 1 month symptoms; 6+ months of continuous illness
- impaired functioning
Schizophreniform
- 2 or more symptoms; at least one core symptom
- 1 month symptoms; less than 6 months of continuous illness
- impaired functioning not required
Brief Psychotic Disorder
- one symptom required
- 1 day to 1 month duration
Symptoms of Seasonal Affective Disorder include
- decreased energy
- increased sleep
- overeating and weight gain
- craving for carbs
Mahler’s Object Relations Theory of BPD
“separation-individuation”
BPD vacillates between separation and fear of abandonment
Kernberg’s Caregiver Theory of BPD
unpredictable caregivers that alternate between nurturing and depriving/punitive
causes defenese mechanism of “splitting” (all good or all bad)
Linehan (1978) theory for BPD
BPD caused by pervasive emotion dysregulation;
BPD people were exposed to invalidating environments;
sharing of private experiences met with significant others –> responded in erratic and negative ways
Drugs for Premature Ejaculation
SSRI’s (fluoxetine, sertraline, paroxetine)
TCA (clomipramine)
Drugs for Erectile Function Disorder
Sildenafil Citrate (Viagra)
Tadalafil (Cialis)
Drugs for Female Sexual Arousal Disorder
Testosterone
Parkinson’s disease has low levels of _____ and ____.
Dopamine and Serotonin
Parkinson’s disease often co-occurs with ________?
Depression
40% of people with PD have depression
Depression IS/IS NOT? correlated with extent of motor impairment or duration of PD symptoms
IS NOT
Depression precedes the onset of motor symptoms in ____% of Parkinson’s patients
20%
Four categories of SUD
- impaired control
- social impairment
- Risky Use
- Pharmacological criteria (tolerance/withdrawal)
CBT theories of maintenance of Anorexia nervosa disorder
- Need to control eating
- Self worth = body weight and body image
Alzheimer’s disorder, neuritic plaques found on
hippocampus, amygdala, entorhinal cortex
medial temporal structures
“Permissive” theory of depression
depression caused by low levels of serotonin and norepinephrine (early biochemical theory) low serotonin and high norepinephrine causes mania
“Catelcholamine” hypothesis of depression
low levels of norepinephrine; early biochemical theory
MDD atypical features
hypersomnia, increase in appetite, weight gain (non-vegetative)
CBIT components for tics
habit reversal training, psychoeducation, relaxation training
Most common comorbid disorders of Tourette’s
ADHD and OCD
Best predictors for Alcohol are…
family history of alcoholism
Core feature of CD
violation of the rights of others and/or rules and societal norms
Hypokalemia
low levels of serum potassium that can lead to kidney failure and cardiac arrest; caused by anorexia due to imbalanced electrolytes
Ritalin works on ____% of people with ADHD
80%
Childhood-onset fluency disorder–how many children recover?
65-85%
Tourette’s disorder is chronic, and the frequency of the symptoms__________ in adolescence or adulthood
Declines
Comprehensive Behavioral treatment (CBIT)
Empirically supported treatment for Tourette’s that combines habit reversal training, with psychoeducation and relaxation techniques.
Bipolar I
at least one manic episode (distinct, period of abnormally and persistently elevated, expansive, or irritable mood and abnormally and persistently increased goal-directed activity or energy) lasts for one week
Bipolar I prevalence
.6% for 12 month prevalence
1.1:1 prevalence ratio; male to female
90% of individuals who have one episode have additional episodes
Bipolar I avg. age of onset
18
Bipolar I etiology
Hereditary (family history of Bipolar disorder strongest predictor of risk)
Life stressors can precipitate the onset of symptoms
Bipolar I Treatment
Lithium (mood-stabilizing drug–reduce periods of mania, prevent mood swings, reduce suicide risk)
Antiseizure medication (valproate, carbamazepine) alternative to those who are intolerant of lithium
Bipolar I Treatment (therapy)
Cognitive Behavioral Therapy–identify and alter thought patterns contributing to symptoms
Interpersonal and Social Rhythm Therapy (IPSRT)–recognize the impact on interpersonal activities and relationships on social and circadian rhythms and regularize those rhythms so they can gain control over their mood cycles
Family-focused treatment (FFT)–brief treatment for patients and their family members that includes psychoeducation, communication enhancement training, and problem-skills training
Bipolar II Disorder
At least one hypomanic (lasts at least four days) and one major depressive episode (lasts at least two weeks)
Cyclothymic
multiple periods of hypomanic and depressive symptoms (not full mdd) for at least two years;
symptoms present half the time and not without symptoms for more than two months.
Major Depressive Disorder
5 or more symptoms with at least one being a depressed mood or loss of interest or pleasure
MDD specifiers
with atypical features–significant weight gain, or increase in appetite, hypersomnia, leaden paralysis, pattern of interpersonal rejection sensitivity with peripartum onset—symptoms began during pregnancy or within 4 weeks postpartum; 10-20% have MDD after birth; .1% to .2 % develop postpartum psychosis with seasonal pattern—occurs at a particular time of year; beginning of fall and continuing into the winter months. Due to disruption of circadian rhythms resulting in increased melatonin which causes drowsiness and lower serotonin.
SAD symptoms
lack of energy, hypersomnia, increased appetite and weight gain, carbohydrate craving
MDD prevalence
7% 12-month prevalence; 18-29 3x more likely than 60+ after puberty females 1.5-3x rate of males Peak age of onset is mid-20s The initial episode triggered by stressful event; but additional episodes relate to # of prior episodes rather than presence of stressor
Current MDD biochemical hypothesis
high level of cortisol that causes degeneration of cells in the hippocampus
Behavioral and Cog. Behavioral Explanations for Depression
- Seligmans “learned helplessness model” (1978) 2. Lewinsohn’s “behavioral theory” (1974) 3. Beck’s “cognitive theory of depression” (1976) 4. Rehm’s “self-control” model
Seligman’s “learned helplessness model”
Depression caused by uncontrollable negative life events. Caused by stable, internal, global factors (own incompetence).
Lewinson’s behavioral therapy
no response-contingent reinforcement of adaptive behaviors and reinforcement of non-adaptive behaviors by sympathy from others pessimism, low self-esteem, social isolation, dsyphoria
Beck’s “cognitive theory of depression”
negative self-statements about self, world, and future “depressive cognitive triad”
Rehm’s “self-control” model
self-monitoring–attend more to neg. vs. pos life events self evaluation–strict standards of eval and internal attributions to neg. events self reinforcement–insufficient reinforcement and excessive punishment
Depression symptoms in children
physical complaints, irritability, social withdrawal
Depression symptoms in older adults is called…
pseudodementia–memory loss, distractibility, disorientation, and other cog. symptoms
Three types of Antidepressants
Tricyclics(TCA’s) Selective Serotonin Reuptake Inhibitors (SSRI’s) Monoamine oxidase inhibitors (MAOI’s)
Treatment for Depression
CBT Interpersonal Therapy
Combo of CBT and antidepressants ______ more effective than either alone
“somewhat”
But therapy has slightly better long term effects;
overall long term prospects not good across CBT, IPT, or Tricyclics
Schizophrenics are most likely to have ________ hallucinations
auditory
Negative Symptoms of Schizophrenia
anhedonia–reduced capacity to experience pleasure avolition–reduced motivation and goal orientation alogia–absence of speech
Depression is linked to elevated levels of this hormone
cortisol
causes a degeneration of cells in the hippocampus, which causes memory problems
Agoraphobia
presence of fear or anxiety related to 2 out of 5 situations:
1) public transport
2) open spaces
3) enclosed spaces
4) standing in line or being in a crowd
5) outside the home alone
* fear that escape will be difficult or help will be unavailable if a panic attack occurs*
Rate for MDD for adolescent and adult females vs. males
1.5-3x rate of females to males
Rate of MDD for prepubescent males and females
about the same
Treatment of choice for most anxiety disorders
in vivo exposure with response prevention
Duration of seperation anxiety must last at least…{children vs. adults]
4 weeks in children and 6 months in adults