Neurons Flashcards
When the cell becomes even more negative,
… the neuron is LESS likely to fire (IPSP). This is a graded potential.
Soma
Cell body
Flow of information in a neuron
- Dendrites receive information
- Cell body processes information
- Axon sends information via terminal buttons
Saltatory Conduction
Faster to travel along the myelinated neuron
Glial cells
Support neurons. Insulate neurons by enclosing in a myelin sheath
Dendrites vs. Axons
- Dendrites not myelinated
- Dendrite branching pattern can change through life, where axons remain stable through aging
- Dendrites can regenerate, axons cannot
- Dendrites receive information, axons send information
Conduction within the neuron is…
Conduction between neurons is…
… electrical
… chemical
Stages of action potential
- Resting potential
- Depolarization
- Actional potential
- Hyperpolarization
Resting potential
Negative. More potassium inside and more sodium outside. This is maintained by the sodium-potassium pump.
Depolarization
Stimulus causes membrane potential to increase threshold potential.
Action potential spike
Membrane becomes positive as sodium ions rush into the cell.
Absolute refractory period.
Repolarization
Potassium ions leave the cell and negative charge is restored.
Hyperpolarization
Cell becomes even more negative than it is at resting potential.
Relative refractory period. Really strong stimulus has to occur in order for another action potential to happen.
Axon hillock
Point where action potential originates. Where axon meets cell body. Graded potential converted into all-or-nothing potential of axon.
Chemical transmission between neurons
- receptor sites - binding
- remain in cleft
- reuptake
Postsynaptic potential
When NT binds to receptor site on dendrite, generates electrical charge (PSP)
1. EPSP: more likely to fire
2. IPSP: less likely to fire
These are GRADED. Vary in intensity.
Graded potential: PSP
Few NT bind to receptors, then less strong.
More NT bind to receptors, then stronger.
Weakens as they travel along the dendrites.
Peptides
2+ amino acids tied together
Endorphins
Take long to have effects on PS cell than NT
Acetylcholine
Parasympathetic: transmit nerve impulses to muscles
CNS: Alzheimer’s - transmission to hippocampus
Catecholamines
Monoamines.
1. Epinephrine
2. Norepinephrine - alertness, awakefulness
3. Dopamine - movement and posture
Too much = mania. Too little = depression
Dopamine
Too much = mania. Too little = depression
Also associated with schizophrenia
and Parkinsons. Too little in the basal ganglia causes illness
Tardive Dyskinesia
Meds for psychosis impact the motor system as well.
L-dopa
For Parkinson’s. Can cross the blood-brain barrier.
Increases production of dopamine. But not too much, because then you get mania!
Serotonin
Monamine.
Regulates mood, sleep, eating, arousal.
Too much = mania. Too little = depression
SSRIs
GABA
Inhibitory postsynaptic potentials. Stabilizes neuro activity in the brain.
Hyperpolarization of PS membrane
Endorphins
Peptides. Pain killers.
Depressants
Benzos and barbituates.
Enhance the action of GABA and stabilize brain activity.
Stimulants
- Amphetamines- stimulate receptors for dopamine, norepinephrine, serotonin
- Antidepressants - tricyclics (block monoamines), MAO inhibitors
- SSRIs - inhibits the reuptake of serotonin
Narcotics
Pain killers that bind to opiate receptors in the brain
- Opium
- Heroin
- Morphine
Antipsychotics
Block receptor sites for dopamine
- Thorazine
- Chlorpromazine
- Phenothiazine
- Haloperidol
- Lithium for bi-polar
MAO
Breaks down and deactivates norepinephrine and serotonin
Methylphenidate
Increases alertness and decreases motor activity
Used for ADHD
Endocrine System
Hormones. Slower-acting.
Adrenaline vs. (epinephrine as a NT)
Adrenaline as a NT
Epinephrine
Pituitary
Anterior is what matters. Controlled by the hypothalamus. Secretes to the other endocrine glands so that they can make their own characteristic hormones to release into the bloodstream.
Dopamine
Too much: Schizophrenia
Too little: Parkinson’s (basal ganglia)
Norepinephrine
Mania/depression
Serotonin
Mania/depression
Acetylcholine
Alzheimer’s
GABA
Anxiety disorders
Endorphin
Pain killer