Neurons 2

Question 1

What is the neurotrophin hypothesis?

Answer 1

target-derived factors contribute to the survival of neurons`

Question 2

What is NGF?

Answer 2

helps with neuronal survival
also influences neuronal differentiation, including neurite outgrowth, soma size, and expression of neurotransmitter phenotype

Question 3

What are the responding neurons for NGF?

Answer 3

sympathetic, small sensory, basal forebrain ,cholinergic.

Question 4

What are the responding neurons for NT-3?

Answer 4

large sensory, sympathetic, motorneurons, dopaminergic, doradrenergic

Question 5

What are the target tissues for NGF?

Answer 5

skin, cortex, hippocampus

Question 6

What are the target tissues for NT-3?

Answer 6

skin, brain, esp. during early devo.

Question 7

What kinds of receptors do small neurons in the DRG have?

Answer 7

trkA receptors, which bind NGF

makes sense, since NGF comes from skin target organs ans small neurons tend to carry pain

Question 8

What kinds of receptors do large neurons express?

Answer 8

trkC repectors, which bind NT-3. (important for motor function)

Question 9

What kinds of receptors do cholinergic neurons of the basal forebraine express?

Answer 9

trkA and p75 NGF receptors

Question 10

What happens if you cut the fornix?

Answer 10

degeneration of cholinergic neurons in septum that innervate the hippocampus and loss of memory. can be treated with NGF.