Neuronal Diversity Flashcards
What are the three sources of neuronal diversity?
Genetic
Epigentic
Environmental
What is somatic mosaicism
Two or more genetically distinct populations of cells in an individual
What is the law of coverage?
That true cell types are evenly spaced within the brain
Excitatory neurons in Cerebellum?
Granule Cells
Inhibitory neurons in Cerebellum
Purkinjie, Golgi, Basket, Stellate
Pyramidal Neurons
80% of cortical neurons, not unique to cortex
Multipolar with large arbor and long unique branching axon collaterals
Chandelier Cells
Axon has cartridges with boutons
Paravalbumin neuropeptide
Synapses onto axon hillock of pyramidal
Basket Cells
Two types in cortex
Purkinje Cells
Inhibitory projection neurons with high arborization
Golgi Cells
Large inhibitory interneuron
Cerebellar Basket and Stellate Cells
small interneurons
Granule Cells
smallest excitatory neuron
What are three inhibitory neurons in the neocortex
Chandelier, Small basket, and Large Basket
What is the main excitatory neuron in neocortex?
Pyramidal Neuron
Defining characteristics of Chandelier cell
Axon has cartridges with boutons Located in cortex Synapses onto pyramidal neurons at axon hillock Uses paravalbumin neuropeptide Fast Spiking
