Neuromuscular Flashcards
1
Q
What is THE key feature of presentation of myasthenia gravis?
A
“fluctuating, fatigable weakness.”
2
Q
Myasthenia gravis is an autoimmune disorder that…
A
Affects the postsynaptic neuromuscular junction via autoantibody binding to the NICOTINIC acetylcholine receptors (AChR Ab)
3
Q
What’s the first-line treatment of myasthenia gravis
A
Corticosteroids (prednisone) are most commonly used
If MG is refractory or steroid-sparing agents desired then immunomodulating meds are used
4
Q
What are some of the commonly used immunomodulating medications in MG?
A
azathioprine cyclosporine cyclophosphamide IVIG PLEX mycophenolate mofetil THYMECTOMY
5
Q
What is the FDA black box warning for MMF?
A
- Increases susceptibility to infection
- Increases risk of developing lymphoma
- May increase risk of pregnancy loss and congenital malformations
6
Q
Common side effects of MMF
A
GI intolerance (diarrhea) N/v Headaches Bone marrow suppresion Sepsis HTN Tremor Neoplasm Depression Teratogenicity Infection
