Neurology Flashcards

1
Q

Receptive aphasia aka..

A

Wernicke’s aphasia

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2
Q

Area of lesion in Wernicke’s (receptive) aphasia

A

Superior temporal gyrus

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3
Q

Blood supply to superior temporal gyrus

A

Inferior division of left MCA

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4
Q

Presentation of Wernicke’s aphasia

A

Sentences that make no sense, word substitution, and neologisms, but speech remains fluent - ‘word salad’

Comprehesion is impaired

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5
Q

Expressive aphasia aka…

A

Broca’s aphasia

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6
Q

Area of lesion in Broca’s aphasia

A

Inferior frontal gyrus

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7
Q

Blood supply to inferior frontal gyrus

A

Superior division of left MCA

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8
Q

Presentation of Broca’s aphasia

A

Speech non-fluent, laboured, halting
Repetition is impaired

Comprehension normal

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9
Q

Area of lesion in conduction aphasia

A

Arcuate fasiculus (connection between Wernicke’s and Broca’s area)

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10
Q

Presentation of conduction aphasia

A

Speech fluent but repetition poor, aware of errors

Comprehension normal

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11
Q

Location of lesion in global aphasia

A

Large lesion affecting all 3 areas (superior temporal gyrus, inferior frontal gyrus, arcuate fasiculus)

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12
Q

When should anti-epileptics be started following first seizure

A
  • Neurological deficit
  • Brain imaging shows structural abnormality
  • EEG shows unequivocal epileptic activity
  • Patient or their family/carers considers risk of having further seizure unacceptable
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13
Q

First line treatment generalised tonic-clonic seizures

A

Men - sodium valproate
Females - lamotrigine or levetiracetam

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14
Q

First line treatment focal seizures

A

Lamotrigine or levetiracetam

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15
Q

Second line treatment focal seizures

A

Carbamazepine, oxcarbazepine, zonisamide

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16
Q

First line treatment absence seizures

A

Ethosuximide

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17
Q

Second line treatment absence seizures

A

Male - sodium valproate
Female - lamotrigine or levetiracetam

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18
Q

Effect of carbamazepine in absence seizures

A

May exacerbate

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19
Q

First line treatment myoclonic seizures

A

Male - sodium valproate
Females - levetiracetam

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20
Q

First line treatment tonic or atonic seizures

A

Male - sodium valproate
Female - lamotrigine

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21
Q

CN I aka

A

Olfactory nerve

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22
Q

CN I function

A

Smell

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23
Q

CN II aka

A

Optic nerve

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24
Q

CN II function

A

Sight

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25
CN III aka
Oculomotor nerve
26
CN III function
- Eye movement - medial rectus, inferior oblique, superior rectus, inferior rectus - Pupil constriction - Accommodation - Eyelid opening
27
CN III palsy presentation
- Ptosis - 'Down and out' eye - Dilated, fixed pupil
28
CN IV aka
Trochlear
29
CN IV function
Eye movement - superior oblique
30
CN IV palsy presentation
Defective downward gaze → vertical diplopia
31
CN V aka
Trigeminal
32
CN V function
- Facial sensation - Mastication
33
CN V lesion presentation
- Trigeminal neuralgia - Loss of corneal reflex (afferent) - Loss of facial sensation - Paralysis of mastication muscles - Deviation of jaw to weak side
34
CN VI aka
Abducens
35
CN VI function
Eye movement - lateral rectus
36
CN VI palsy presentation
Palsy results in defective abduction to horizontal diplopia
37
CN VII aka
Facial nerve
38
CN VII function
- Facial movement - Taste to anterior 2/3 of tongue) - Lacrimation - Salivation
39
CN VII lesion presentation
- Flaccid paralysis of upper and lower face - Loss of corneal reflex (efferent) - Loss of taste - Hyperacusis
40
CN VIII aka
Vestibulocochlear
41
CN VIII function
- Hearing - Balance
42
CN VIII lesion presentation
- Hearing loss - Vertigo - Nystagmus
43
CN IX aka
Glossopharyngeal
44
CN IX function
- Taste to posterior 1/3 of tongue - Salivation - Swallowing - Mediates input from carotid body and sinus
45
CN IX lesion presentation
- Hypersensitive carotid sinus reflex - Loss of gag reflex (afferent)
46
CN X aka
Vagus
47
CN X function
- Phonation - Swallowing - Innervates viscera
48
CN X lesion presentation
- Deviated uvula from site of lesion - Loss of gag reflex
49
CN XI aka
Accessory
50
CN XI function
Head and shoulder movement
51
CN XI lesion presentation
Weakness turning head to contralateral side
52
CN XII aka
Hypoglossal
53
CN XII function
Tongue movement
54
CN XII lesion presentation
Tongue deviates towards side of lesion
55
Afferent limb of corneal reflex
Opthalmic (division of trigeminal) nerve
56
Efferent limb of corneal reflex
Facial nerve
57
Afferent limb of jaw jerk reflex
Mandibular reflex
58
Efferent limb of jaw jerk reflex
Mandibular nerve
59
Afferent limb of gag reflex
Glossopharyngeal nerve
60
Efferent limb of gag reflex
Vagal nerve
61
Afferent limb of carotid sinus reflex
Glossopharyngeal nerve
62
Efferent limb of carotid sinus reflex
Vagal nerve
63
Afferent limb of pupillary light reflex
Optic nerve
64
Efferent limb of pupillary light reflex
Oculomotor nerve
65
Afferent limb of lacrimation reflex
Ophthalmic nerve
66
Efferent limb of lacimation reflex
Facial nerve
67
Anterior cerebral artery stroke features
- Contralateral hemiparesis and sensory loss - Lower extremity > upper
68
Middle cerebral artery stroke features
- Contralateral hemiparesis and sensory loss - Upper extremity > lower - Contralateral homonymous hemianopia - Aphasia
69
Posterior cerebral artery stroke features
- Contralateral homonymous hemianopia with macular sparing - Visual agnosia
70
What arteries affected in Weber's syndrome
Branches of posterior cerebral artery supplying the midbrain
71
Weber's syndrome features
- Ipsilateral CN III palsy - Contralateral weakness of upper and lower extremity
72
What arteries infected in Wallenberg syndrome (lateral medullary syndrome)
Posterior inferior cerebellar artery
73
Wallenberg (lateral medullary) syndrome features
Ipsilateral - facial pain and temperature loss Contralateral - limb/torso pain and temperature loss Ataxia Nystagmus
74
Artery affected in lateral pontine syndrome
Anterior inferior cerebellar arteryF
75
Features of lateral pontine syndrome
Ipsilateral - facial pain and temperature loss, facial paralysis, deafness Contralateral - limb/torso pain and temperature loss Ataxia Nystagmus
76
Retinal artery stroke features
Amaurosis fugax
77
Basilar artery stroke features
Locked in syndrome
78
Lacunar stroke features
Either isolated hemiparesis, hemisensory loss, or hemiparesis with limb ataxia
79
Capgras syndrome
Delusion that friend or partner has been replaced by identical looking imposter
80
Othello syndrome
Irrational belief partner is having affair with no objective evidence
81
De clerambault syndrome
Delusional idea that person whom they consider to be of higher social and/or professional standing is in love with them
82
Cotard syndrome
Delusional idea one is dead
83
Examples 5-HT3 antagonists
Ondansetron Palanostetron
84
Use 5-HT3 antagonists
Mainly management of chemotherapy related nausea
85
SEs 5HT3 receptor antagonists
Prolonged QT interval Constipation
86
Advantage palanosetron over ondansetron
Reduced effect on QT interval
87
Inheritance ataxia telangiectasia
Autosomal recessive
88
When does ataxia telangiectasia present
Early childhood
89
Features ataxia telangiectasia
Cerebellar ataxia Telangiectasia IgA deficiency → recurrent chest infections
90
Malignancy and ataxia telangiectasia
10% risk of developing malignancy - lymphoma, leukaemia, non-lymphoid tumours
91
What is Bell's palsy
Acute, unilateral, idiopathic facial nerve paralysis
92
Features Bell's palsy
Lower motor neuron facial nerve palsy → forehead affected Post-auricular pain Altered taste Dry eyes Hyperacusis
93
Management Bells palsy
Oral pred within 72 hours of onset ?Antivirals if severe facial nerve palsy Eye care - artificial tears, eye lubricants, tape eye closed at bedtime
94
Importance of eye care Bell's palsy
Prevent exposure keratopathy
95
Referral criteria Bell's palsy
If paralysis shows no signs of improvement after 3 weeks, refer urgently to ENT
96
When to consider referral to plastic surgery Bell's palsy
For more long-standing weakness, e.g. several months
97
Prognosis Bell's palsy
Most people make full recovery within 3-4 months If untreated, around 15% of patients have permanent moderate to severe weakness
98
Causes brain abscess
- Extension of sepsis from middle ear or sinuses - Trauma or surgery to scalp - Penetrating head injuries - Embolic events from endocarditis
99
Presentation brain asbcess
Depends on site of abscess, those in critical sites, e.g. motor cortex will present earlier Headache Fever (may be absent, usually not swinging) Focal neurology Nausea Papilloedema Seizures
100
Investigation brain abscess
CT scanning
101
Management brain abscess
Craniotomy and debridement of abscess IV antibiotics ICP management
102
Limitation of craniotomy and debridement of brain abscess
Abscess may reform because head is closed following drainage
103
IV antibiotics used in brain abscess
3rd gen cephalosporin + metronidazole
104
What is used for ICP management in brain abscess
Dexamethasone
105
Use of carbamazepine
Epilepsy, particularly partial seizures - most common use Trigeminal neuralgia Bipolar disorder
106
Adverse effects carbamazepine
P450 enzyme inducer Dizziness and ataxia Drowsiness Headache Visual disturbance, esp diplopia Steven-Johnson syndrome Leucopenia and agranulocytosis Hyponatraemia secondary to SIADH
107
What is cataplexy
Sudden transient loss of muscular tone caused by strong emotion
108
What is Charcot-Marie-Tooth disease
Most common hereditary peripheral neuropathy, resulting in predominant motor loss
109
Management Charcot-Marie-Tooth disease
No cure, management focused on physical and occupational therapy
110
Features Charcot-Marie-Tooth disease
- Foot drop - High arched feet - Hammer toes - Distal muscle weakness - Distal muscle atrophy - Hyporeflexia - Stork leg deformity May be history of frequently sprained ankles
111
Risk factors cluster headaches
Male Smoker
112
Triggers cluster headaches
Alcohol Noctural sleep
113
Features cluster headaches
Intense sharp, stabbing pain around one eye, each episode lasting 15 mins - 2 hours Redness, lacrimation, and lid swelling Nasal stuffiness Miosis and ptosis in minority
114
How long do clusters last in cluster headaches
4-12 weeks Occur around once a year
115
Investigations cluster headaches
MRI with gadolinium contrast - underlying brain lesions sometimes found
116
Referral cluster headaches
Should speak specalist advice from neurologist if patient develops cluster headaches
117
Acute management cluster headaches
100% oxygen SC triptan
118
Prophylaxis cluster headaches
Verapamil
119
Treatment paroxysmal hemicrania
Indomethacin
120
What does sciatic nerve divide into
Tibial and common peroneal nerves
121
Where does injury to common peroneal nerve occur
Neck of fibula
122
Features common peroneal nerve
Foot drop Weakness of foot dorsiflexion Weakness of foot eversion Weakness of extensor hallucis longus Sensory loss over dorsum of foot and lower lateral part of leg Wasting of anterior tibial and perioneal muscles
123
Risk factors degenerative cervical myelopathy
- Smoking - Genetics - Occupations exposing patients to high axial loading
124
Degenerative cervical myelopathy symptoms
Pain affecting neck, upper, or lower limbs Loss of motor function - loss of digital dexterity, arm or leg weakness/stiffness leading to impaired gait and imbalance Loss of sensory function causing numbness Loss of autonomic function (urinary or faecal incontinence and/or impotence)
125
What is Hoffmans sign
Gently flicking one finger on a pateints hand → reflex twitching of other fingers on same hand Suggests cervical myelopathy
126
Investigation degenerative cervical myelopathy
MRI of cervical spine
127
Findings MRI cervical spine in degenerative cervical myelopathy
Disc degeneration and ligament hypertrophy, with cord signal change
128
Referral degenerative cervical myelopathy
All patients need urgent referral for assessment by specialist spinal services (neurosurgery or ortho spinal)
129
Why is timing of surgery important in DCM
Any existing spinal cord damage can be permanent, early treatment (within 6 months of diagnosis) offers best chance of full recovery
130
Treatment DCM
Decompressive surgery
131
Role of observation in DCM
Close observation is option for mild stable disease
132
Role of physio in DCM
Should only be initiated by specialist services, as manipulation can cause more spinal cord damage
133
C2 dermatome landmark
Posterior half of skull (cap)
134
C3 dermatome landmark
High turtleneck shirt
135
C4 dermatome landmark
Low-collar shirt
136
C5 dermatome landmark
Ventral axial line of upper limb
137
C6 dermatome landmark
Thumb and index finger
138
C7 dermatome landmark
Middle finger and palm of hand
139
C8 dermatome landmark
Ring and little finger
140
T4 dermatome landmark
Nipples
141
T5 dermatome landmark
Inframammary fold
142
T6 dermatome landmark
Xiphoid process
143
T10 dermatome landmark
Umbilicus
144
L1 dermatome landmark
Inguinal ligament
145
L4 dermatome landmark
Knee caps
146
L5 dermatome landmark
Big toe, dorsum of foot
147
S1 dermatome landmark
Lateral foot, small toe
148
S2-3 dermatome landmark
Genitalia
149
Drugs causing peripheral neuropathy
Amiodarone Isoniazid Vincristine Nitrofurantoin Metronidazole
150
DVLA advice first unprovoked/isolated seizure
6 months off if no relevant structural abnormalities on brain imaging, and no definite epileptiform activity on EEG If these conditions not met, 12 months
151
DVLA advice established epilepsy or multiple unprovoked seizures
May qualify for driving license if seizure free for 12 months
152
DVLA advice withdrawal of epilepsy medication
Should not drive whilst anti-epilepsy medication being withdrawn, and for 6 months after last dose
153
DVLA advice simple faint
No restriction
154
DVLA advice single episode syncope, explained and treated
4 weeks off
155
DVLA advice single episode unexplained syncope
6 months off driving
156
DVLA advice two or more episodes syncope
12 months off
157
DVLA advice stroke/TIA
1 month off, may not need to inform DVLA if no residual neurological deficit
158
DVLA advice multiple TIAs over short period of time
3 months off, inform DVLA
159
DVLA advice pituitary tumour
If craniotomy, 6 months If trans-sphenoidal, can drive when no debarring residual impairment likely to affect safe driving
160
DVLA advice narcolepsy/cataplexy
Cease driving on diagnosis, can restart once satisfactory control of symptoms
161
DVLA advice chronic neurological disorders, e.g. MS, MND
Inform DVLA, complete PK1 form (application for driving license holders state of health)
162
Inheritance pattern dystrophinopathies
X linked recessive
163
DMD presentation
Progressive proximal muscle weakness from 5 years Calf pseudohypertrophy Gower's sign 30% have intellectual impairment
164
What is Gower's sign
Child uses arms to stand up from squatted position
165
Beckers muscular dystrophy age of presentation
After 10 years
166
Features encephalitis
Fever Headache Psychiatric symptoms Seizures Vomiting Focal features, e.g. aphasia
167
Most common cause encephalitis
HSV-1 - 95% of cases in adults
168
Areas of brain affected in encephalitis
Temporal and inferior frontal lobes typically
169
CSF in encephalitis
Lymphoctosis Elevated protein
170
Neuroimaging in encephalitis
Medial temporal and inferior frontal changes, e.g. petechial haemorrhages Normal in 1/3
171
Best imaging modality in encephalitis
MRI
172
EEG in encephalitis
Lateralised periodic discharges at 2Hz
173
Management encephalitis
IV aciclovir
174
Features of temporal lobe seizures
May occur with or without impairment of consciousness Aura in most patients Typically last around one minute - automatisms, e.g. lip smacking/grabbing/plucking
175
Auras in temporal lobe seizures
Typically a rising epigastric sensation Psychic or experiential phenomena, e.g. deja vu, jamais vu Less commonly hallucinations - auditory, gustatory, olfactory
176
Features of frontal lobe seizures
Head/leg movements Posturing Post-ictal weakness Jacksonian march
177
Features of parietal lobe seizures
Paraesthesia
178
Features occipital lobe seizures
Floaters/flashes
179
Inheritance pattern essential tremor
Autosomal dominant
180
Essential tremor
Postural tremor, worse if arms outstretched Improved by alcohol and rest Affects upper limbs and titubation (head tremor)
181
Management essential tremot
Propanolol first line Primidone sometimes used
182
What is supplied by the facial nerve
Face - muscles of expression Ear - nerve to stapedius Taste - anterior 2/3 of tongue Tear - parasympathetic fibres to lacrimal glands, also salivary g lands
183
Causes of bilateral facial nerve palsy
Sarcoidosis Guillain-Barre syndrome Lyme diseae Bilateral acoustic neuromas, e.g. in NF2 Bilateral Bells palsy
184
Difference between LMN and UMN facial nerve palsy
UMN spares upper face (forehead), LMN affects all facial muscles
185
Causes of LMN facial nerve palsy
Bell's palsy Ramsay-Hunt syndrome Acoustic neuroma Parotid tumours HIV MS Diabetes mellitus
186
Causes of UMN facial nerve palsy
Stroke MS
187
Inheritance Friedreich's ataxia
Autosomal recessive
188
Genetic defect in Friedreich's ataxia
Trinucleotide repeat disorder - GAA repeat in X25 gene on chromosome 25
189
What is unusual about Friedreich's ataxia
It does not demonstrate anticipation
190
Age of onset Friedreich's ataxia
10-15
191
Most common presenting features Friedreich's ataxia
Gait ataxia Kyphoscoliosis
192
Neurological features Friedreich's ataxia
Absent ankle jerks/extensor plantars Cerebellar ataxia Optic atrophy Spinocerebellar tract degeneration
193
Other features Friedreich's ataxia
Hypertrophic obstructive cardiomyopathy (90%) Diabetes mellitus High arched palate
194
GCS motor scoring
6 - obeys commands 5 - localises to pain 4 - withdraws from pain 3 - abnormal flexion to pain 2 - extending to pain 1 - none
195
GCS verbal scoring
5 - orientated 4 - confused 3 - words 2 - sounds 1 - none
196
GCS eye scoring
4 - spontaneous 3 - to speech 2 - to pain 1 - none
197
What is Guillain-Barre syndrome
Immune-mediated demyelination of the peripheral nervous system often triggered by an infection
198
Infection classically triggering Guillian-Barre syndrome
Campylobacter jejuni
199
Antibody correlated with clinical features in Guillian-Barre syndrome
Anti-GM1
200
What is Miler Fisher syndrome
Variant of Guillain-Barre syndrome, associated with opthalmoplegia, areflexia, and ataxia. Eye muscles usually affected first
201
Guillain-Barre syndrome vs Miller Fisher syndrome
Guillain-Barre ascending paralysis, Miller Fisher syndrome descending paralysis
202
Antibody seen in Miller Fisher syndrome
Anti-GQ1b (90%)
203
Presentation Guillain-Barre
65% experience back/leg pain in initial stages of the illness Progressive, symmetrical weakness of all limbs, classically ascending, reflexes reduced or absent, sensory symptoms mild with few sensory signs Resp muscle weakness Cranial nerve involvement (diplopia, bilateral facial nerve palsy, oropharyngeal weakness) Autonomic involvement (urinary retention, diarrhoea) Less commonly, papilloedema (secondary to reduced CSF resorption)
204
Investigations in Guillain-Barre syndrome
Lumbar puncture Nerve conduction studies
205
LP findings Guillain-Barre syndrome
Rise in protein with normal WCC
206
Nerve conduction studies findings Guillain-Barre syndrome
Decreased motor nerve conduction velocity Prolonged distal motor latency Increased F wave latency
207
Features tension headache
Recurrent, non-disabling, bilateral headache, often described as tight-band
208
Features medication overuse headache
Present for 15 days or more per month Developed or worsened whilst taking regular symptomatic medication May be psychiatric co-morbidity
209
Highest risk medicines for medication overuse headache
Opioids Triptans
210
Where in brain characteristically affected by herpes simplex encephalitis
Temporal (and inferior frontal) lobes
211
Features herpes simplex encephalitis
Fever Headache Psychiatric symptoms Seizures Vomiting Focal features, e.g. aphasia
212
Are peripheral lesions e.g. cold sores related to HSV encephalitis
No
213
CSF findings HSV encephalitis
Lymphocytosis Elevated protein
214
CT findings HSV encephalitis
Medial temporal and inferior frontal changes, e.g. petechial haemorrhages
215
EEG pattern HSV encephalitis
Lateralised periodic discharges at 2Hz
216
Treatment HSV encephalitis
IV aciclovir
217
Inheritance pattern Huntington's disease
Autosomal dominant
218
Genetic defect Huntington's disease
Trinucleotide repeat disorder - repeat expansion of CAG
219
Pathophysiology Huntington's disease
Degeneration of cholinergic and GABAergic neurons in the striatum of the basal ganglia
220
Age of onset Huntington's disease
35 Anticipation may be seen, where the disease presents at an earlier age in successive generations
221
Features Huntington's disease
Chorea Personality changes, e.g. irritability, apathy, depression Intellectual impairment Dystonia Saccadic eye movements
222
Risk factors idiopathic intracranial hypertension
Obesity Female Pregnancy Drugs
223
Drugs increasing risk of IIH
COCP Steroids Tetracyclines Retinoids (isotretinoin, tretinoin), vitamin A Lithium
224
Features IIH
Headache Blurred vision Papilloedema Enlarged blind spot 6th nerve palsy may be present
225
Management IIH
Weight loss Carbonic anhydrase inhibitors, e.g. acetazolamide Topiramate Repeated lumbar puncture for short term management Surgery
226
Medications for weight loss in IIH
Semaglutide Topiramate (particularly good as inhibits carbonic anhydrase) For specialist consideration
227
Surgery IIH
Optic nerve sheath decompression and fenestration - prevent damage to optic nerve Lumboperitoneal or ventriculoperitoneal shunt - reduce intracranial pressure
228
What is internuclear opthalmoplegia
Horizontal disconjugate eye movement due to a lesion in the medial longitudinal fasciculus
229
What is internuclear opthalmoplegia
Horizontal disconjugate eye movement due to a lesion in the medial longitudinal fasciculus
230
What is the role of the medial longitudinal fasciculus
Controls horizontal eye movements by interconnecting the 3rd, 4th, and 6th cranial nerve
231
Where is the medial longitudinal fasciculus located?
In the paramedian area of the midbrain and pons
232
Features internuclear opthalmoplegia
Impaired adduction of the eye on the same side as the lesion Horizontal nystagmus of the abducting eye on the contralateral side
233
Causes internuclear opthalmoplegia
Multiple sclerosis Vascular disease
234
Location of intracranial venous thrombosis
50% have isolated sagittal sinus thromboses Remainder have co-existent lateral sinus thromboses and cavernous sinus thromboses
235
Features intracranial venous thrombosis
Headache, may be sudden onset Nausea and vomiting Reduced consciousness
236
Investigation intracranial venous thrombosis
MRI venography gold standard, CT venography alternative
237
D-dimer in intracranial venous thrombosis
May be elevated
238
Management intracranial venous thrombosis
Anticoagulation - typically low molecular weight heparin → warfarin for longer term anticoagulation
239
Presentation sagittal sinus thrombosis
May present with seizures and hemiplegia
240
Imaging findings sagittal sinus thrombosis
'Empty delta sign' on venography Parasagittal biparietal or bifrontal haemorrhagic infarctions sometimes seen
241
Causes other than intracranial venous thrombosis of cavernous sinus syndrome
- Local infection, e.g. sinusitis - Neoplasia - Trauma
242
Features cavernous sinus thrombosis
Periorbital erythema and oedema Opthalmoplegia - 6th nerve damage typically occurs before 3rd and 4th Trigeminal nerve involvement may lead to hyperaesthesia of upper face and eye pain Central retinal vein thrombosis
243
Features lateral sinus thrombosis
6th and 7th nerve palsies
244
What vessels involved in lacunar stroke
A single penetrating branch of a large cerebral artery
245
What structures affecting in lacunar stroke
- Internal capsule - Thalamus - Basal ganglia
246
Potential lacunar stroke syndromes
- Purely motor (most common) - Purely sensory - Sensorimotor stroke - Ataxic hemiparesis - Dysarthria-clumsy hand syndrome
247
Features ataxic hemiparesis caused by lacunar stroke
Ipsilateral weakness and limb ataxia that is out of proportion to motor deficit
248
What do lacunar strokes typically lack
Cortical findings, such as aphasia, agnosia, neglect, apraxia, or hemianopsia
249
Causes Lambert-Eaton syndrome
Small cell lung cancer (most common) Breast cancer Ovarian cancer May occur independently as autoimmune disorder
250
Pathophysiology Lambert-Eaton syndrome
Antibody directed against presynaptic voltage-gated calcium channel in the peripheral nervous system
251
Features Lambert-Eaton syndrome
- Repeated muscle contractions lead to increased muscle strength - Limb-girdle weakness, affecting lower limbs first - Hyporeflexia - Autonomic symptoms - dry mouth, impotence, difficulty micturating
252
EMG findings Lambert-Eaton syndrome
Incremental response to repetitive electrical stimulation
253
Treatment Lambert-Eaton syndrome
Treatment of underlying cancer if present Immunosuppression, e.g. pred and/or azathioprine 3,4-diaminopyridine IV immunoglobulin Plasma exchange
254
Lambert-Eaton syndrome vs myasthenia gravis
Muscle strength in Lambert-Eaton, weakness in MG Opthalmoplegia and ptosis in MG, not LES
255
Use lamotrigine
Second line anti-epileptic for variety of generalised and partial seizures
256
Mechanism of action lamotrigine
Sodium channel blocker
257
Adverse effects lamotrigine
Stevens-Johnson syndrome
258
Complications meningitis
Sensorineural hearing loss (most common) Seizures Focal neurological deficit Sepsis, intracerebral abscess Brain herniation, hydrocephalus
259
Complications meningococcal meningitis
Waterhouse-Friderichsen syndrome
260
What is Waterhouse-Friderichsen syndrome
Adrenal insufficiency secondary to adrenal haemorrhage
261
Diagnostic criteria migraine
A - at least 5 attacks fulfilling B-D B - headache lasting 4-72 hours C - at least two of; - unilateral location - pulsating quality - moderate or severe - aggravation by/causing avoidance of routine activity D - during headache, at least one of - nausea/vomiting - photophobia/phonophobia E - not attributed to another disorder
262
Differences in migraines in children
- Shorter lasting - More commonly bilateral - GI disturbance
263
Migraine aura symptoms requiring investigation/referral
- Motor weakness - Double vision - Visual symptoms affecting only one eye - Poor balance - Decreased consciousness
264
First line acute treatment migraine
Combo therapy with; - Oral triptan and NSAID, or - Oral triptan and paracetamol
265
Acute migraine treatment in 12-17y/o
Nasal triptan rather than oral
266
Second line treatment acute mgiraine
Non-oral metaclopramide or prochlorperazine Considering adding non-oral NSAID or triptan
267
Why caution in prescribing metaclopramide to young patients
Acute dystonic reactions may develop
268
When to give migraine prophylaxis
Migraine attacks having significant impact on quality of life and daily function, e.g. more than once a week on average, or prolonged and severe despite optimal acute treatment
269
First line options for migraine prophylaxis
Propanolol Topiramate (not women of childbearing age) Amitriptyline
270
Second line treatment migraine prophylaxis
Course of up to 10 sessions of acupuncture over 5-8 weeks
271
Treatment predictable menstrual migraine
Frovatriptan 2.5mg twice a day, or Zolmitriptan 2.5mg BD-TDS
272
Specialist treatment options for migraine prophylaxis
Candesartan Monoclonal antibodies directed against calcitonin gene-related peptipe receptor, e.g. erenumab
273
Use of pizotifen migraine prophylaxis
No longer recommended
274
What is multiple sclerosis
Chronic cell-mediated autoimmune disorder characterised by demyelination in the CNS
275
Demographics MS
3x more common in women 20-40 years Higher latitudes
276
Features relapsing remitting MS
Acute attacks (1-2 months) following by periods of remission
277
Features secondary progressive MS
Relapsing-remitting patients who have deteriorated and have developed neurological signs and symptoms between relapses Gait and bladder disorders generally seen
278
Features primary progressive disease
Progressive deterioration from onset More common in older people
279
Diagnostic criteria MS
Two or more relapses, and either; - Objective clinical evidence of two or more lesions - Objective clinical evidence of one lesion, together with reasonable historical evidence of an additional relapse
280
Visual features MS
- Optic neuritis - Optic atrophy - Uhthoff's phenomenon - Internuclear opthalmoplegia
281
What is Uhthoff's phenomenon
Worsening of vision following rise in body temperature
282
Sensory features MS
- Pins/needles - Numbness - Trigeminal neuralgia - Lhermitte's syndrome
283
What is Lhermitte's syndrome
Parasthesiae in limbs on neck flexion
284
Motor features MS
Spastic weakness - most commonly seen in legs
285
Cerebellar features MS
Ataxia Tremor
286
Other features MS
Urinary incontinence Sexual dysfunction Intellectual deterioration
287
MRI findings MS
High signal T2 lesions Periventricular plaques Dawson fingers - hyperintense lesions penpendicular to the corpus callosum
288
CSF findings MS
Oligoclonal bands (and not in serum) Increased intrathecal synthesis of IgG
289
Visual evoked potentials in MS
Delayed, but well preserved waveform
290
Management acute relapse MS
High dose steroids (oral or IV methylpred) may be given for up to 5 days
291
Action of steroids in acute relapse MS
Shorten the duration of relapse, but do not alter the degree of recovery
292
Indications for disease modifying drugs in MS
- Relapsing remitting disease + 2 relapses in the past 2 years + able to walk 100m unaided - Secondary progressive disease + 2 relapses in the past 2 years + able to walk 10m (aided or unaided)
293
Disease modifying drug options MS
Natalizumab Ocrelizumab Fingolimod Beta-interferon Glatiramer acetate
294
Usual first line disease modifying drug MS
Natalizumab or ocrelizumab
295
Route of administration natalizumab
IV
296
Route of administration ocrelizumab
IV
297
Route of administration fingolimod
Oral formulations available
298
Route of administration beta-interferon
SC/IM
299
Route of administration glatiramer acetate
SC
300
What disease modifying drugs for MS considered less effective
Beta-interferon and glatiramer acetate
301
Treatment fatigue in MS
Once other problems, e.g. anaemia, thyroid, depression ruled out, trial amantadine
302
First line treatment spasticity MS
Baclofen Gabapentin Physio
303
Other options spasticity MS
Diazepam Dantrolene Tizanidine
304
Treatment bladder dysfunction in MS
Ultrasound to assess bladder emptying If significant residual volume - intermittent self-catheterisation If no significant residual volume - anticholinergics
305
What is oscillopsia
When visual fields appear to oscillate
306
Treatment oscillopsia MS
Gabapentin
307
Types of multiple system atrophy
MSA-P - predominant Parkinsonian features MSA-C - predominant cerebellar features
308
Features multiple systems atrophy
Parkinsonism Autonomic disturbance - erectile dysfunction, postural hypotension, atonic bladder Cerebellar signs
309
Drugs exacerbating myasthenia gravis
Penicillamine Quinidine Procainamide Beta-blockers Lithium Phenytoin Gentamicin, macrolides, quinolones, tetracyclines
310
Age of onset myotonic dystrophy
20-30 years
311
Inheritance myotonic dystrophy
Autosomal dominant
312
Genetics myotonic dystrophy
Trinucleotide repeat disorder
313
Myotonic dystrophy DM1 vs DM2
Distal weakness more prominent in DM1 Proximal weakness more prominent DM2, severe congenital form not seen
314
Facial features myotonic dystrophy
Myotonic facies (long, haggard appearance) Frontal balding Bilateral ptosis Cataracts Dysarthria
315
Other features myotonic dystrophy
Myotonia (tonic spasm of muscle) Weakness of arms and legs (distal initially) Mild mental impairment Diabetes mellitus Testicular atrophy Cardiac involvement - heart block, cardiomyopathy Dysphagia
316
Inheritance neurofibromatosis
Autosomal dominant
317
Features neurofibromatosis type 1
Cafe-au-lait spots (≥6 15mm in diameter) Axillary/groin freckles Peripheral neurofibromas Iris hamatomas (Lisch nodules) Scoliosis Phaeochromocytomas
318
Features neurofibromatosis type 2
Bilateral vesticular schwannomas Multiple intracranial schwannomas, meningiomas, ependymomas
319
Drugs causing neuroleptic malignant syndrome
Antipsychotics Dopaminergic drugs, e.g. levodopa (usually when stopped or suddenly reduced)
320
When does neuroleptic malignant syndrome occur
Usually hours to days of starting an antipsychotic
321
Features neuroleptic malignant syndrome
Pyrexia Muscle rigidity Autonomic lability - hypertension, tachycardia, tachypnoea Agitated delirium with confusion
322
Bloods neuroleptic malignant syndrome
Raised AKI AKI in severe cases Leukocytosis
323
Management neuroleptic malignant syndrome
Stop antipsychotic IV fluids Dantrolene
324
First line treatment neuropathic pain
Amitriptyline Duloxetine Gabapentin Pregabalin
325
Second line treatment neuropathic pain
Switch to one of the other first line drugs (not add)
326
'Rescue therapy' for exacerbations of neuropathic pain
Tramadol
327
Treatment localised neuropathic pain
Topical capsaicin
328
Causes normal pressure hydrocephalus
Reduced CSF absorption at arachnoid villi, may be secondary to head injury, SAH, or meningitis
329
Features normal pressure hydrocephalus
Urinary incontinence Dementia and bradyphrenia (slowing of mental processes) Gait abnormality
330
Timeline of symptom development normal pressure hydrocephalus
Develop over a few months
331
Imaging normal pressure hydrocephalus
Hydrocephalus with ventriculomegaly in absense of, or out of proportion to, sulcal enlargement
332
Management normal pressure hydrocephalus
Ventriculoperitoneal shunting
333
Complications VP shunt in normal pressure hydrocephalus
- Seizures - Infection - Intracerebral haemorrhages
334
Cause Parkinson's disease
Degeneration of dopaminergic neurons in the substantia nigra
335
Features Parkinson's disease
Bradykinesia Tremor Rigidity
336
Characteristic of symptoms in Parkinsons
Classically asymmetrical
337
Features of bradykinesia in Parkinson's disease
Poverty of movement (hypokinesia) Short, shuffling steps, reduced arm swing Difficulty in initiating movement
338
Features of tremor in Parkinson's disease
Most marked at rest, 3-5Hz Worse when stressed or tired, improves with voluntary movement Typically pill-rolling
339
Features of rigidity in Parkinsons disease
Lead pipe Cogwheel - due to superimposed tremor
340
Other features of Parkinson's disease
Mask like facies Flexed posture Micrographia Drooling of saliva Psychiatric features Impaired olfaction REM sleep behaviour disorder Fatigue Autonomic dysfunction - postural hypotension
341
Drug induced Parkinsonism vs Parkinson's disease
Motor symptoms generally rapid onset and bilateral Rigidity and rest tremor uncommon
342
Investigation Parkinsons disease
Diagnosis usually clinical If difficulty differentiating between essential tremor and Parkinson's disease, consider SPECT
343
First line treatment Parkinson's disease
If motor symptoms affecting patients quality of life - levodopa If motor symptoms not affecting patients quality of life - dopamine agonist, levodopa, or monoamine oxidase B
344
Levodopa vs dopamine agonists vs MAO-B inhibitors
Levodopa more improvement in motor symptoms. and ADL than dopamine agonists/MAO-B inhibitors Levodopa more motor complications Dopamine agonists greatest adverse effects
345
Treatment Parkinsons when continued symptoms despite optimal levodopa treatment, or developed dyskinesia
Add dopamine agonist, MAO-B inhibitor or COMT inhibitor
346
Dopamine agonists vs MAO-B inhibitors vs COMT inhibitors
Dopamine agonists most off-time reduction COMT most adverse events, MAO-B least Dopamine agonists most risk of hallucinations
347
Risk if Parkinsons medication not taken/not absorbed/drug holiday
Acute akinesia or neuroleptic malignant syndrome
348
Risk factors for impulse control disorders with Parkinsons medication
- Dopamine agonist therapy - History of previous impulsive behaviours - History of alcohol consumption and/or smoking
349
Management excessive daytime sleepines Parkinson's disease
Adjust medications Modafinil if alternative medications fail Should not drive
350
Management orthostatic hypotension in Parkinson's
Medication review If symptoms persist, midodrine
351
Management drooling in Parkinsons
Glycopyrronium bromide
352
What medication is levodopa combined with
Decarboxylase inhibitor, e.g. carbidopa, benserazide
353
Why is levodopa combined with decarboxylase inhibitor
Prevents peripheral metabolism of levodopa to dopamine outside the brain, hence can reduce SEs
354
Common adverse effects levodopa
- Dry mouth - Anorexia - Palpitations - Postural hypotension - Psychosis
355
Adverse effects due to difficulty in achieving steady dose levodopa
- End of dose wearing off (symptoms worsen towards end of dosage interval → decline in motor activity) - On-off phenomenon (large variations in motor performance - Dyskinesias at peak dose - dystonia, chorea, athetosis
356
Management if patients unable to take levodopa orally
Dopamine agonist patch as rescue medication
357
Examples ergot derived dopamine receptor agonists
Bromociptine Cabergline
358
Examples non-ergot derived dopamine receptor agonists
Ropinirole Apomorphine
359
Adverse effects ergot-derived dopamine receptor agonists
Pulmonary, retroperitoneal, and cardiac fibrosis
360
Monitoring ergot-derived dopamine receptor agonists
Echo, ESR, creatinine and CXR obtained prior to treatment Patients should be closely monitored
361
Other adverse effects dopamine receptor agonists
- Impulse control disorders - Excessive daytime somnolence - Hallucinations - Nasal congestion - Postural hypotension
362
Example MAO-B inhibitor
Selegiline
363
SEs amantidine
Ataxia Slurred speech Confusion Dizziness Lived reticularis
364
Examples COMT inhibitors
Entacapone Tolcapone
365
Use of COMT inhibitors in Parkinsons
Used in conjunction with levodopa - COMT is enzyme involved in breakdown of dopamine
366
Use of antimuscarinics in Parkinsons
Now used more to treat drug-induced Parkinsonism rather than idiopathic Parkinson's disease
367
Examples antimusarinics used in Parkinsons
Procyclidine Benzotropine Trihexyphenidyl
368
Causes of Parkinsonism
Parkinson's disease Drug induced, e.g. antipsychotics, metoclopramide Progressive supranuclear palsy Multiple systems atrophy Wilson's disease Post-encephalitis Dementia pugilistica Toxins - carbon monoxide, MPTP
369
What causes dementia pugilistic
Chronic head trauma, e.g. boxing
370
Causes of peripheral neuropathy with predominantly motor loss
Guillain-Barre syndrome Porphyria Lead poisioning Hereditary sensorimotor neuropathies, e.g. Charcot-Marie-Tooth Chronic inflammatory demyelinating polyneuropathy Diptheria
371
Causes of peripheral neuropathy causing predominantly sensory loss
Diabetes Uraemia Leprosy Alcoholism Vitamin B12 deficiency Amyloidosis
372
Cause of alcohol neuropathy
Direct toxic effects of alcohol and reduced absorption of B vitamins
373
Alcohol neuropathy sensory vs motor symptoms
Sensory symptoms typically present prior to motor symptoms
374
How does vitamin B12 deficiency cause peripheral neuropathy
Subacute combined degeneration of the spinal cord
375
Order of presentation peripheral neuropathy secondary to vitamin B12 deficiency
Dorsal column usually affected first (joint position, vibration) prior to distal parenthesis
376
Effect of phenytoin on P450
Inducer
377
Acute SEs phenytoin
- Dizziness - Diplopia - Nystagmus - Slurred speech - Ataxia - Confusion - Seizures
378
Common chronic SEs phenytoin
- Gingival hyperplasia - Hirsutism - Coarsening of facial features - Drowsiness
379
Other chronic SEs phenytoin
- Megaloblastic anaemia - Peripheral neuropathy - Enhanced vitamin D metabolism causing osteomalacia - Lymphadenopathy - Dyskinesia
380
Idiosyncratic SEs phenytoin
- Fever - Rashes, inc severe reactions e.g. TEN - Hepatitis - Dupuytren's contracture - Aplastic anaemia - Drug induced lupus
381
Teratogenic effects phenytoin
- Cleft palate - CHD
382
Monitoring phenytoin
Check trough levels (immediately before dose) if; - Adjustment of phenytoin dose - Suspected toxicity - Suspicion of non-adherence
383
Features progressive supranuclear palsy
- Postural instability and falls, stiff broad-based gait - Impairment of vertical gaze - down gaze worse than up gaze - Parkinsonism, bradykinesia prominent - Cognitive impairment, primarily frontal lobe dysfunction
384
L-dopa in progressive supranuclear palsy
Poor response to L-dopa
385
Factors favouring psychogenic non-epileptic seizures
- Pelvic thrusting - Family member with epilepsy - Much more common in females - Crying after seizure - Don't occur when alone - Gradual onset
386
Factors favouring true epileptic seizures
- Tongue piting - Raised serum prolactin
387
Roots of radial nerve
C5-T1
388
Muscle affected in injury to radial nerve at shoulder
Long head of triceps
389
Effect of injury to radial nerve at shoulder
Minor affects on shoulder stability in abduction
390
Muscle affected in injury to radial nerve at arm
Triceps
391
Effect of injury to radial nerve at arm
Loss of elbow extension
392
Muscle affected in injury to radial nerve at forearm
- Supinator - Brachioradialis - Extensor carpi radialis longus and brevis
393
Effect of injury to radial nerve at forearm
Weakening of supination of prone hand and elbow flexion in mid prine position
394
Sensory loss in radial nerve injury
Small area between dorsal aspect of 1st and 2nd metacarpals
395
Normal ICP when supine
7-15
396
What is the cerebral perfusion pressure
The net pressure gradient causing cerebral blood flow to the brain
397
How to calculate cerebral perfusion pressure
MAP - ICP
398
Causes raised ICP
- Idiopathic intracranial hypertension - Traumatic head injuries - Infection, e.g. meningitis - Tumours - Hydrocephalus
399
Features raised ICP
- Headache - Vomiting - Reduced level of consciousness - Papilloedema - Cushing's triad
400
What is Cushing's triad
- Widening pulse pressure - Bradycardia - Irregular breathing
401
Investigations raised ICP
- Neuroimaging (CT/MRI) to determine underlying cause - Invasive ICP monitoring
402
Cut off for intervention in invasive ICP monitoring
>20mmHg
403
Management raised ICP
- Treat underlying cause - Head elevation to 30 - IV mannitol - Controlled hyperventilation - Removal of CSF
404
How does controlled hyperventilation help in raised ICP
Reduce pCO2 → vasoconstriction of cerebral arteries → reduced ICP
405
Limitation of controlled hyperventilation in raised ICP
- Temporary - May reduce blood flow to already ischaemic parts of the brain
406
Methods for CSF removal
- Drain from intraventricular monitor - Repeat LP - VP shunt
407
Root of ankle reflex
S1-2
408
Root of knee reflex
L3-4
409
Root of biceps reflex
C5-6
410
Root of triceps reflex
C7-8
411
What is restless legs syndrome
Syndrome of spontaneous, continuous lower limb movements, may be associated with paresthesia
412
Features restless leg syndrome
- Uncontrollable urge to move legs - initially at night, but progress to occur during day, worse at rest - Paresthesias, e.g. crawling or throbbing sensations - Movements during sleep - periodic limb movements of sleep
413
Associations with restless leg syndrome
- Iron deficiency anaemia - Uraemia - Diabetes mellitus - Pregnancy
414
Basic management restless legs syndrome
- Simple measures - walking, stretching, massaging affected limbs - Treat any iron deficiency
415
First line drug treatment restless legs syndrome
Dopamine agonists, e.g. pramipexole, ropinorole
416
Other drug treatments restless legs syndrome
Benzodiazepines Gabapentin
417
What is Reye's syndrome
Severe progressive encephalopathy affecting children, accompanied by fatty infiltration of the liver, kidneys, and pancreas
418
Cause Reye's syndrome
Unclear Association with aspirin use Potential viral cause
419
Peak incidence Reye's syndrome
2 years
420
Features Reye's syndrome
- Encephalopathy - confusion, seizures, cerebral oedema, coma - Fatty infiltration of the liver, kidneys, and pancreas - Hypoglycaemia
421
Managment Reye's syndrome
Supportive
422
Roots sciatic nerve
L4-5, S1-3
423
What does sciatic nerve divided into
Tibial and common peroneal nerves
424
Muscles supplied by sciatic nerve
- Hamstrings - Adductors
425
Motor features of sciatic nerve lesion
Paralysis of knee flexion and all movements below knee
426
Sensory features of sciatic nerve lesion
Loss below knee
427
Reflexes in sciatic nerve lesion
Ankle and plantar lost Knee jerk in tact
428
Causes sciatic nerve lesion
- Fracture neck of femur - Posterior hip dislocation - Trauma
429
Teratogenic effects of sodium valproate
- Neural tube defects - Neurodevelopmental delay
430
P450 and sodium valproate
P450 inhibitor
431
SEs sodium valproate
- Nausea - Increased appetite and weight gain - Alopecia - Ataxia - Tremor - Hepatotoxicity - Pancreatitis - Thrombocytopenia - Hyponatraemia - Hyperammonaemic encephalopathy
432
Definition status epilepticus
Single seizure lasting >5 minutes ≥2 seizures within 5 min period without person returning to normal
433
First line treatment status epilepticus in pre-hosp setting
PR diazepam or buccal midazolam
434
First line treatment status epilepticus in hospital
IV lorazepam
435
Second line treatment status epilepticus in hospital
Repeat IV lorazepam after 5-10 mins
436
Third line treatment status epilepticus
Levetiracetam, phenytoin, or sodium valproate
437
Advantages levetiracetam as third line treatment for status
May be quicker to administer and have fewer adverse effects than other options
438
Fourth line treatment for status epilepticus, and when to give
Induction of general anaesthesia or phenobarb If no response within 45 mins from onset - refractory status
439
Effect of stroke of anterior cerebral artery
Contralateral hemiparesis and sensory loss Lower extremity>upper
440
Effect of stroke of middle cerebral artery
Contralateral hemiparesis and sensory loss, upper extremity > lower Contralateral homonymous hemianopia Aphasia
441
Effect of stroke of posterior cerebral artery
- Contralateral homonymous hemianopia with macular sparing - Visual agnosia
442
What artery is affected in Weber's syndrome
Branches of posterior cerebral artery that supply the midbrain
443
Effect of stroke affecting branches of PCA supplying midbrain
- Ipsilateral CN III palsy - Contralateral weakness of upper and lower extremity
444
What is lateral medullary syndrome
Stroke affecting posterior inferior cerebellar artery
445
Effect of stroke affecting posterior inferior cerebellar artery
- Ipsilateral facial pain and temp loss - Contralateral limb/torso pain and temp loss - Ataxia - Nystagmus
446
What is lateral pontine syndrome
Stroke affecting inferior cerebellar artery
447
Effect of stroke affecting anterior inferior cerebellar artery
- Ipsilateral facial paralysis and deafness - Contralateral limb/torso pain and temp loss - Ataxia - Nystagmus
448
Effect of stroke affecting retinal/opthalmic arteyr
Amaurosis fugax
449
Effect of stroke affecting basilar artery
Locked in syndrome
450
Common sites of lacunar strokes
Basal ganglia Thalamus Internal capsule
451
Criteria in Oxford Stroke Classification
1. Unilateral hemiparesis and/or hemisensory loss of face, arm, and leg 2. Homonymous hemianopia 3. Higher cognitive dysfunction, e.g. dysphasia
452
What arteries does total anterior circulation infant involve
Middle and anterior cerebral artery
453
Oxford criteria and TACI
All 3 Oxford criteria present
454
What arteries does partial anterior circulation infarct involve
Smaller arteries of anterior circulation, e.g. upper or lower division of middle cerebral artery
455
Oxford criteria in PACI
2 Oxford criteria are present
456
What arteries involve in lacunar infarcts
Perforating arteries around internal capsule, thalamus, and basal ganglia
457
Presentation lacunar infarcts
One of; - Unilateral weakness (and/or sensory deficit) of face and arm, arm and leg, or all 3 - Pure sensory stroke - Ataxic hemiparesis
458
What arteries involved in posterior circulation stroke
Vertebrobasilar arteries
459
Presentation posterior circulation stroke
1 of; - Cerebellar or brainstem syndromes - Loss of consciousnes - Isolated homonymous hemianopia
460
Features suggesting more like haemorrhagic stroke
- Reduced consciousness level - Headache - N&V - Seizures
461
Common management TIA
Aspirin 300mg immediately unless contraindicated
462
When is urgent admission indicated TIA
- More than 1 TIA (crescendo TIA) - Suspected cardioembolic source - Severe carotid stenosis - Bleeding disorder or anticoagulant (imaging to r/o haemorrhage)
463
Management TIA within last 7 days
Assessment within 24 hours by stroke specialist
464
Management TIA over a week ago
Specialist assessment ASAP, within 7 days
465
Management haemorrhagic stroke
Neurosurgical review ?surgical intervention Usually supportive - stop anticoag/antithrombotics, reversal Lower BP
466
Management of BP in acute ischaemic stroke
Should not be lowered in acute phase unless complications,e .g. hypertensive encephalopathy, being considered for thrombolysis
467
Common management acute ischaemic stroke
Aspirin 300mg ASAP once haemorrhage excluded
468
Management of AF in ischaemic stroke
Should not be started until brain imaging has excluded haemorrhage, and usually not until 14 days after onset
469
Management hypercholesterolaemia in stroke
If cholesterol >3.5, statin Delay until at least 48 hours after due to risk of haemorrhagic transformatino
470
Criteria for thrombolysis in acute ischaemic stroke
- Can be administered within 4.5 hours of onset of stroke symptoms - Imaging has excluded haemorrhage
471
When can thrombolysis be considered beyond 4.5 hours
If; - Treatment can be started between 4.5 and 9 hours of known onset, or within 9 hours of the midpoint of sleep when they have woken with symptoms, and - Evidence on CT/MR perfusion or MRI of the potential to salvage brain tissue
472
What agent should be used for stroke thrombolysis
Alteplase or tenecteplase Alteplase if >4.5 hours
473
Should thrombolysis be performed if a patient is having thrombectomy
Yes
474
BP and thrombolysis
BP should be lowered to 185/110 before thrombolysis
475
Absolute contraindications to thrombolysis
- Previous intracranial haemorrhage - Seizure at onset of stroke - Intracranial neoplasm - Suspected SAH - Stroke or TBI in prev 3 months - LP in past 7 days - GI haemorrhage in past 3 weeks - Active bleeding - Oesophageal varices - Uncontrolled hypertension >200/120mmHg
476
Relative contraindications to thrombolysis
- Pregnancy - Concurrent anticoagulation (INR >1.7) - Haemorrhagic diathesis - Active diabetic haemorrhagic retinopathy - Suspected intracardiac thrombus - Major surgery/trauma in prev 2 weeks
477
Which patients are eligible for thrombectomy
- Pre-stroke functional status of less than 3 on modified Rankin scale - Score of more than 5 on National Institutes of Health Stroke Scale (NIHSS)
478
Timeline thrombectomy
Less than 6 hours Offer if 6-24 hours from when last known well and imaging shows salvagable brain
479
Which arteries thrombectomy
Proximal anterior circulation Consider if proximal posterior circulation (basilar of posterior cerebral artery) and imaging showing salvageable brain
480
Antiplatelet in secondary prevention of stroke
Clopidogrel Aspirin if CI/not tolerated
481
When should carotid endarterectomy be considered in stroke
- Stroke or TIA in carotid territory - Not severely disabled - Stenosis >50%
482
Timeline carotid endarterectomy stroke
ASAP within 7 days
483
Cause subacute degeneration of spinal cord
- Vitamin B12 deficiency - Recreational nitrous oxide inhalation (because it causes B12 def)
484
Structures affected in subacute degeneration of the spinal cord
- Dorsal column - Lateral corticospinal tract - Spinocerebellar tract
485
Features of subacute degeneration of the spinal cord due to dorsal column involvement
- Distal tingling/burning/sensory loss, symmetrical, legs>arms - Impaired proprioception and vibration sense
486
Features of subacute degeneration of the spinal cord due to lateral corticospinal tract involvement
- Muscle weakness, hyperreflexia, spasticity - Upper motor neuron signs - Brisk knee reflexes - Absent ankle jerks - Extensor plantars
487
Features of subacute degeneration of the spinla cord due to spinocerebellar involvement
- Sensory ataxia → gait abnormalities - Positive Romberg's sign
488
What is syringomyelia
A collection of CSF in the spinal cord
489
What is syringobulbia
Fluid-filled cavity within medulla of brainstem
490
Causes syringomyelia
- Chiari malformation - Trauma - Tumours - Idiopathic
491
Features syringomyelia
- Cape like (neck, shoulders, arms) loss of sensation to temp, but preservation of light touch, proprioception, and vibration - Spastic weakness, predominantly lower limbs - Neuropathic pain - Upgoing plantars - Autonomic features - Horner's syndrome - Bladder and bowel dysfunction
492
Investigations syringomyelia
Full spine MRI - exclude tumour or tethered cord Brain MRI - exclude Chiari malformation
493
Treatment syringomyelia
Treat cause of syrinx If persistent or symptomatic, shunt into syrinx
494
Features third nerve palsy
- Eye is deviated 'down and out' - Ptosis - Pupil may be dilated
495
Causes third nerve palsy
- Diabetes mellitus - Vasculitis, e.g temporal arteritis, SLE - Posterior communicating artery aneurysm - Cavernous sinus thrombosis - Weber's syndrome - Amyloid - MS
496
When might third nerve palsy be a false localising sign
Uncal herniation through tentorium if raised ICP
497
TIA mimics
Hypoglycaemia Intracranial haemorrhage
498
Role of CT brain in TIA
Should not be done unless clinical suspicion of alternative diagnosis that CT could detect, e.g. exclude haemorrhage
499
Role of MRI brain in TIA
- Determine territory of ischaemia - Detect haemorrhage or alternative pathologies
500
Initial management TIA
Aspirin 300mg
501
Ongoing management TIA
Clopidogrel + aspirin (or ticagrelor) for 21 days, then clopi ongoing
502
Management TIA if not suitable for DAPT
Clopidogrel
503
Management AF in TIA
Anticoagulate as soon as haemorrhage excluded
504
Statin in TIA
High intensity statin, e.g. atorvastatin 20-80mg daily
505
Features of tremor in Parkinsonism
Resting pill rolling tremor
506
Features of tremor in essential tremor
Postural tremor, worse if arms outstretched Improved by alcohol and rest Titubation (nodding head movement)
507
Features of tremor in cerebellar disease
Intention tremor Occurs with cerebellar signs, e.g. past-pointing, nystagmus
508
Features of trigeminal neuralgia
- Brief electric shock like pains, abrupt onset and termination, limited to one or more divisions of trigeminal nerve - Pain commonly evoked by light touch - Small areas in nasolabial fold or chin may be particularly susceptible (trigger areas) - Main usually remit for variable periods
509
Red flags for serious underlying cause in trigeminal neuralgia
- Sensory changes - Deafness or other ear problems - History of skin or oral lesions that could spread perineurally - Pain only in opthalmic division of trigeminal near (eye socker, forehead, nose) or bilaterally - Optic neuritis - FHx MS - Age of onset before 40
510
Management trigeminal neuralgia
Carbamazepine first line
511
Referral trigeminal neuralgia
- Failure to respond to treatment - Atypical feature
512
Adverse effects triptans
- Tingling - Heat - Tightness of throat and chest - Heaviness - Pressure
513
CIs triptans
History of or significant risk factors for IHD or CVD
514
Inheritance tuberous sclerosis
Autosomal dominant
515
Cutaneous features tuberous sclerosis
- Depigmented ash leaf spots which flouresce under UV light - Shagreen patches - roughened patches of skin over lumbar spine - Adenoma sebaceum (angiofibromas) - butterfly distribution over nose - Subungal fibromata (under nails) - Cafe-au-lait spots
516
Neurological features tuberous sclerosis
- Developmental delay - Epilepsy - Intellectual impairment
517
Other features tuberous sclerosis
- Retinal hamartomas (dense white areas on retina) - Rhabdomyomas of heart - Polycystic kidneys, renal angiomyolipomata - Multiple lung cysts
518
Roots ulcer nerve
C8, T1
519
Sensory function ulnar nerve
Medial 1 1/2 fingers (palmar and dorsal)
520
Presentation ulnar nerve damage at wrist
- Claw hand - Wasting and paralysis of intrinsic hand muscles (except lateral two lumbricals) - Wasting and paralysis of hypothenar muscles - Sensory loss to medial 1 1/2 fingers
521
What is claw hand
Hyperextension of the metacarpophalangeal joints and flexion at the distal and proximal interphalangeal joints of the 4th and 5th digits
522
Presentation ulnar nerve damage at elbow
- Claw hand (less severe than at wrist) - Wasting and paralysis of intrinsic hand muscles (except lateral two lumbricals) - Wasting and paralysis of hypothenar muscles - Sensory loss to medial 1 1/2 fingers - Radial deviation of wrist
523
Presentation vestibular schwannoma (acoustic neuroma)
- Vertigo - Unilateral sensorineural hearing loss - Unilateral tinnitus - Absent corneal reflex - Facial palsy
524
Cause bilateral acoustic neuroma
Neurofibromatosis type 2
525
Investigation acoustic neuroma
MRI of cerebellopontine angle
526
Management acoustic neuroma
Surgery, radiotherapy, or observation
527
What causes homonymous hemianopia
Lesion of the opposite optic tract (e.g. left homonymous hemianopia = right optic tract)
528
What is an incongruous visual field defect
Incomplete or asymmetric visual loss
529
What does an incongruous visual field defect suggest
Optic tract lesion
530
What is a congruous visual field defect
Complete or symmetrical visual loss
531
What does a congruous visual field defect suggest
Optic radiation lesion or occipital cortex lesion
532
What does macula sparing suggest
Lesion of occipital cortex
533
Cause of superior homonymous quadrantanopia
Lesion of inferior optic radiations in temporal lobe (Meyer's loop)
534
Cause of inferior homonymous quadrantanopia
Lesion of superior optic radiations in parietal lobe
535
Cause of bitemporal hemianopia
Lesion of optic chiasm
536
Cause of bitemporal hemianopia upper quad > lower quad
Inferior chiasmal compression, commonly pituitary tumour
537
Cause of bitemporal hemianopia lower quad > upper quad
Superior chiasmal compression, commonly craniopharyngioma
538
What is Wernicke's encephalopathy
Neuropsych disorder caused by thiamine deficiency
539
Causes Wernicke's encephalopathy
- Alcoholic (most common) - Persistent vomiting - Anorexia - Stomach cancer - Dietary deficiency
540
Features Wernicke's encephalopathy
- Oculomotor dysfunction - nystagmus, ophthalmoplegia - Gait ataxia - Encephalopathy - confusion, disorientation, indifference, inattentiveness - Peripheral sensory neuropathy
541
Opthalmoplegia in Wernicke's encephalopathy
- Lateral rectus palsy - Conjugate gaze palsy
542
Investigation Wernicke's encephalopathy
- Red cell transketolase - reduced - MRI
543
Treatment Wernicke's encephalopathy
Urgent replacement of thiamine
544
Features Korsakoff syndrome
- Antero and retrograde amnesia - Confabulation