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1 - MSRA > Cancer > Flashcards

Cancer Flashcards

1
Q

Aflatoxin (produced by aspergillus) causes?

A

Hepatocellular carcinoma

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2
Q

Aniline dyes causes?

A

Bladder TCC

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3
Q

Asbestos causes?

A

Mesothelioma and bronchial carcinoma

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4
Q

Nitrosamines causes?

A

Oesophageal and gastric cancer

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5
Q

Vinyl chloride causes?

A

Hepatic angiosarcomae

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6
Q

SEs cyclophosphamide

A

Haemorrhagic cystitis
Myelosuppression
TCC

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7
Q

SEs bleomycin

A

Lung fibrosis

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8
Q

SEs anthracyclines, e.g. doxorubicin

A

Cardiomyopathy

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9
Q

SEs methotrexate

A

Myelosupression
Mucositis
Liver fibrosis
Lung fibrosis

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10
Q

SEs 5-FU

A

Myelosuppression
Mucositis
Dermatitis

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11
Q

SEs 6-mercaptopurine

A

Myelosuppression

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12
Q

SEs cytarabine

A

Myelosuppression
Ataxia

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13
Q

SEs vincristine

A

Peripheral neuropathy
Paralytic ileus

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14
Q

SEs vinblastine

A

Myelosuppression

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15
Q

SEs docetaxel

A

Neutropenia

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16
Q

SEs irinotecan

A

Myelosuppresion

17
Q

SEs cisplatin

A

Nephrotoxicity
Ototoxicity
Peripheral neuropathy
Hypomagnesaemia

18
Q

SEs hydroxyurea

A

Myelosuppresion

19
Q

Inheritance Li-Fraumeni syndrome

A

Autosomal dominant

20
Q

Problem in Li-Fraumeni syndrome

A

Germline mutations to p53 tumour suppressor gene → high incidence of malignancies, particularly sarcomas and leukaemias

21
Q

BRCA associations

A

Breast cancer
Ovarian cancer
Prostate cancer (BRCA2)

22
Q

Inheritance Lynch syndrome

A

Autosomal dominant

23
Q

Cancers in Lynch syndrome

A

Colon
Endometrial

24
Q

Amsterdam criteria (high risk of Lynch syndrome)

A

3+ family mebers with colorectal cancer (one 1st degree)
2 successive affected generations
1 or more colon cancers diagnosed under 50
FAP excluded

25
Q

Inheritance Gardners syndrome

A

Autosomal dominant

26
Q

Features Gardners syndrome

A

Multiple colonic polyps
Skull osteoma
Thyroid cancer
Epidermoid cyst

27
Q

Investigation suspected MSCC

A

Whole spine MRI within 24 hours

28
Q

Treatment MSCC

A

High dose oral dex
Urgent onc assessment for consideration of radiotherapy or surgery

29
Q

CA125 marker for

A

Ovarian cancer

30
Q

CA 19-9 marker for

A

Pancreatic cancer

31
Q

CA 15-3 marker for

A

Breast cancer

32
Q

AFP marker for

A

Hepatocellular carcinoma
Teratoma

33
Q

CEA marker for

A

Colorectal cancer

34
Q

S-100 marker for

A

Melanoma
Schwannomas

35
Q

Bombesin marker for

A

SCLC
Gastric cancer
Neuroblastoma

1 - MSRA (23 decks)

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