Neurological, Behavioural and Psychological Conditions Flashcards

1
Q

What are the types of burning mouth syndrome?

A

Can be both primary or secondary.

It doesn’t have a definitive diagnosis and treatment.

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2
Q

What is burning mouth syndrome also called?

A

Complex oral sensitivity disorder

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3
Q

What are the symptoms of complex oral sensitivity disorder?

A

“hair in my mouth” “Tingling in my mouth” “burning in my mouth”

Sore mouth

Sore tongue

Glossodynia

Stomatodynia

Oral dysesthesia

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4
Q

What is primary complex oral sensitivity disorder? how is it diagnosed?

A

A neuropathic disorder, diagnosis requires patients to have:

Pain in the mouth present daily and persisting for most of the day.

Oral mucosa of normal appearance

Local and systemic diseases have been excluded

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5
Q

How is secondary burning mouth syndrome different to primary burning mouth syndrome?

A

Oral burning is from or is effected by clinical abnormalities.

Secondary BMS improves with treatment of the underlying cause.

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6
Q

How does burning mouth syndrome present clinically?

A

5th - 7th decade of life uncommon before 30

Spontaneous onset

Increased intensity over time

Pain lasting > 4 months

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7
Q

What are the symptoms of burning mouth syndrome?

A

Positive sensory symptoms:

Burning pain

Dysgeusia (metallic taste)

Dysesthesia

Negative sensory symptoms:

Loss of taste

Parasthesia

Tongue > Labial mucosa > Hard palate

Exacerbated by acidic foods

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8
Q

What are the secondary causes of BMS?

A

Dry mouth (xerostomia, salivary gland hypofunction)

Candidal infection

Immune related conditions (geographic tongue and OLP)

Nutritional deficiencies

Allergies

GORD

Certain medications

Endocrine disorders

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9
Q

How are patients with secondary BMS caused by dry mouth managed?

A

Management is 2 fold:

Stop deleterious effects of dry mouth on oral health (eg fungal infections, CPPACP)

Attempt to provide comfort with salivary substitutes

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10
Q

What should be done for patients with candida infections and symptoms of BMS?

A

Candida needs to be eliminated as a cause of BMS and some clinicians swab the mouth routinely of BMS patients to ensure that this is not a contributing factor

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11
Q

How is candidiasis managed?

A

Eliminate co contributing factors such as diabetes, nutritional deficiencies (B12, B6, RBCs, folate, and iron), etc

Assess systemic factors

Antifungals (Topical azoles, amphotericin B, and nystatin)

Systemic antifungals

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12
Q

How should allergies be managed if they are suspected as the cause of BMS?

A

Conduct a patch test of suspected causes (refer to allerginist)

ACE inhibitors used for the treatment of hypertension have been implicated as causing BMS, changing medication may be an option in patients to assess if this gives any relief.

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13
Q

How can GORD and endocrine disorders be investigated as a cause of secondary BMD?

A

Patients usually have tell-tale signs of GORD most notably bitter or sour tasting saliva and erosion of teeth.

Diabetes and thyroid problems both hyper and hypo are known to produce peripheral neuropathic pain and generalised hyperalgesia so are worth investigating in certain clinical situations. Again especially with diabetes patients will have other oral signs –periodontal disease for example.

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14
Q

What diagnostic tests can be conducted for BMS?

A

FBC

Fe studies

Zn studies

Red cell folate

B vitamins

FBG/GTT (Diabetic nephropathy)

Allergy testing

Oral Swab and culture (Candida)

Oral biopsy (Immune mediated, depletion of small nerve fibes)

No test for primary BMS as it is not caused by known medical or dental causes.

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15
Q

Which psychological disorders are seen in patients with BMD?

A

Anxiety very often

This issue is contentious because no one knows if it is directly caused by BMD or if BMD is caused by the anxiety

Looking at the literature we can see that BMS suffferers often have elevated psychiatric illness be it anxiety or depression but usually not at levels higher than other chronic pain patients.

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16
Q

What aetiologies are seen in patients with primary burning mouth syndrome?

A

The burning mouth pain symptoms occur when there is an abnormal interplay between lingual nerve function and chorda tympani function.

BMS is due to small fibre neurological damage in the oral cavity.

BMS is associated with a decline in endogenous dopamine levels in the putamen which results in altered central nociceptive signal processes.

BMS is due to an upregulation in the heat and capsaicin receptor TRPV1 in nerve fibres. With regard to the upregulation of transient receptor potential vanilloid type 1 and burning pain, mutiple studies have shown an association.

17
Q

How is primary BMS managed?

A

CBT (shown to be effective in reducing the exacerbating factors and symptoms)

SSRIs

TCAs (no evidence for BMS but effective for other neuropathic pain)

Topical clonazepam (RBCT supports its use)

Systemic clonazepam (Some efficacy)

Gabapentin (Case reports)

Pregabalin (No data for BMS)

18
Q

How can stroke be prevented?

A

Smoking cessation

Hypertensive control

Diabetic control

Atrial fibrillation

Hypercholesterolaemia

2dary prevention via antiplatelets/anticoagulants

19
Q

What are the dental issues that can arise from stroke?

A

Oral hygiene more difficult (Large handle toothbrush/electric toothbrush needed)

Facial nerve palsy (Weakness, food debris, denture wearing, potential implant use)

SHOULD BE TREATED AS A MEDICAL EMERGENCY AND AMBULANCE CALLED.

20
Q

How is epilepsy treated?

A

Anti-epileptics

Lifestyle changes.

21
Q

What dental issues can arise from epilepsy?

A

Medication needed prior to dental treatment (48 hours, avoid stressful procedures)

Gingival hyperplasia due to phenytoin/phenobarbitual drugs

Medical emergency if seizure happens (in case of bad situation)

22
Q

What is trigeminal neuralgia?

A

Sudden brief stabbing electric shock pain in areas of trigeminal nerve innervation.

Trivial sensory stimuli trigger it often. Often an isolated trigger point.

If patient is under 40 MS is suspected so refer to hospital.

23
Q

What medications can be provided for trigeminal neuralgia?

A

Carbamezapine

Other drugs

Neurosurgery

24
Q

What dental issues can arise due to trigeminal neuralgia?

A

Pulpitis: Do not commence invasive or irreversible procedures. If following initial dental treatment there’s no improvement consider TgN.

Unstable TgN: Dental treatment may exacerbate condition. LA, swift therapy, and refer.

Can get post traumatic trigeminal neuralgia from dental treatment.

25
Q

What disorders cause issues with swallowing?

A

Aspiration:

Stroke

Traumatic brain injury

Brain tumour

Cerebral palsy

Dementia

Iatrogenic causes (Medication/surgery)

26
Q

How can swallowing dental issues be prevented?

A

Rubber dam

Careful unrushed approach

Reclined over supine

Instruments available to retrieve objects from oropharynx

High volume suction

Dental floss

Head position

27
Q

What are the types of haematological diseases?

A

Alterations in:

RBCs

WBCs

Haemostasis

Neoplasia

Orofacial signs and symptoms may be the first clinical presentation of an underlying haematological disorder

28
Q

What is anaemia? What are the signs?

A

Decrease in number of RBCs or haemoglobin in the body.

Atrophic glossitis

Burning tongue

Mucosal pallor

Angular cheilits

29
Q

What causes iron-deficiency anaemia?

A

Diet

Pregnancy

Blood loss

GI

Menstrual

30
Q

What are the causes of vitB12 deficiency?

A

Necessary for RBC production

Megaloblastic anaemia

Due to pernicious anaemia, surgical resection of the ileum

Antibodies against intrinsic facto

31
Q

What are the symptoms of vitB12 deficiency in the mouth?

A

Stomatitis

Apthous ulcers

Atrophic glossitis

Angular cheilitis

Burning mouth

Paraesthesia, peripheral neuropathy

32
Q

What is folate important for?

A

Synthesize, repair and methylate DNA

Co-factor for biological reactions

Needed for RBC formation

33
Q

What causes folate deficiency?

A

Diet

Drugs (methotrexate)

Pregnancy

34
Q

What are the signs of folic acid deficiency?

A

Apthous ulcers

Atrophic glossitis

Angular cheilitis

Burning mouth

35
Q

What is sickle cell anaemia?

A

Disorders characterised by abnormal haemoglobin production

Results in haemolytic anaemia and vaso-occlusion -> Ischaemic tissue injury

36
Q

What are the outcomes of sickle cell anaemia that can arise?

A

Orofacial pain

Parasthesia of mental nerve

Pulpal necrosis

Prominent maxilla and severe malocclusion

Mandibular infarction

Haemorrhage

Radiographic fundings (step ladder trabeculae pattern, enamel hypomineralisation, calcified canals)

37
Q

What is thalassemia?

A

Inherited haemolytic anaemia involving defects in synthesis of either alpha or beta chain of Hb.

Homozygous forms have most clinical manifestations.

38
Q

What clinical signs are associated with thalassemia?

A

Enlargement of the maxilla due to compensatory marrow hyperplasia

Taurodontism = englargement of pulp spaces

39
Q

What are the clinical features of aplastic anaemia?

A

Oral and facial petechiae