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Endocrinology > Neuroendocrine Tumors > Flashcards

Neuroendocrine Tumors Flashcards

1
Q

NET’s

A

Neoplasms that arise from endocrine and nervous tissue.

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2
Q

MEN Syndromes

A

Multiple Endocrine Neoplasms
Cause overactivity and enlargement, tumors of certain endocrine glands.
Usually inherited
Autosomal dominant
One type of MEN sticks to a single family

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3
Q

MEN-1

A

ParaT tumors
Pancreatic tumors
Pituitary tumors

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4
Q

MEN-2a

A

Medullary thyroid cancers
Pheochromocytoma
Parathyroid
Very rare

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5
Q

MEN-2b

A

Medullary thyroid cancers
Pheochromocytomas
Neuromas

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6
Q

MEN-1 Manifestation

A

Almost all MEN-1 patients develop overactivity of parathyroid (hyperparathyroidism)
Pancreas is next: gastrin and insulin overproduction
Pituitary adenoma occurs in 42% of pt’s

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7
Q

MEN-1 tumors are usually?

A

Benign

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8
Q

MEN-2a will mosr certainly develop which type of cancer?

A

Medullary thyroid cancer
Very aggressive
Begins early on in life
Should have thyroid surgically removed

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9
Q

Testing for MEN-2a

A

ret protooncogene mutation

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10
Q

MEN-2b

A

Medullary thyroid cancers
Pheochromocytoma
Mucosal neuromas

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11
Q

Marfanoid Habitus

A 
Seen in MEN-2b
Long fingers and extremities
Tall, long legs and arms
Pectus Excavatum
Spinal abnormalities
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12
Q

Insulinoma

A 
Rare beta cell tumor that secretes insulin
Evenly distributed
Hyperinsulinemia
Persistant hypoglycemia
More common in women
90% benign
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13
Q

Insulinoma S/S

A

Polyphagia, weight gain
CNS glusoce lack
Whipples triad

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14
Q

Insulinoma Dx

A

Insulin to glucose ratio <.3

Increased levels of C-peptide

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15
Q

Insulinoma Tx

A

Surgery
DIazoxide
Octreotide
Continuous SQ glucagon

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16
Q

Gastrinoma

A

Zollinger-Ellison Syndrome
Tumor of pancreas and duedenum
Excess levels of gastrin
25% part of MEN-1

17
Q

Gastrinoma S/S

A

Frequent peptic ulcers (absence of NSAIDS and H.Pylori
esophagitis
diarrhea

18
Q

Gastrinoma Dx

A

Fasting gastrin > 1000
Somatostatin receptor scintigraphy
Endoscopic ultrasound

19
Q

Gastrinoma Tx

A

Proton pump inhibitors

Surgical removal

20
Q

VIPoma

A

Verner Morrison Syndrome
Pancreatic tumor secreting Vasoactive intestinal polypeptide (VIP)
Tail of pancreas

21
Q

VIPoma S/S

A

Severe, intermittent watery diarrhea
Dehydration and weakness
Decreased gastrin production
Flushing

22
Q

VIPoma Dx

A

Serum VIP levels 75 - 190

CT, US

23
Q

VIPoma Tx

A

Fluid correction

Surgical rescection

24
Q

Glucagonoma

A 
Pancreatic tumor that secretes glucagon
Increased levels of glucagon in blood
Produced rash
80% are cancerous
Grows slowly
80% women
25
Q

Glucagonoma S/S

A

Same as Type 1 DM

Necrolytic migratory erythema

26
Q

Glucagonoma Dx

A

Serum glucagon > 500

Imaging

27
Q

Glucagonoma Tx

A

Surgery

Zinc ointment for rash

Endocrinology (16 decks)

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