Neurobiology of addiction Flashcards
what does CAGE stand for?
cut down, annoyed, guilty, eye opener
what us the ICD 10 dependance writer?
Dependance Physiological withdrawal Tolerance Strong desire for substance Lack of control Neglect previous pleasures Harm - continue to take despite harm
3 areas involved in the reward pathway?
VTA (ventral tangemental area), accumbens nucleus, prefrontal cortex
dopaminergic activity in which part of the brain is involved in normal pleasurable experiences? LINDMARK
mesolimbic system
when do addicts show an increase in activation in OFC?
when presented with drug cues
what would happen in the OFC if an addict is having drug cravings following exposure to drug cues?
hyperactivity
OFC is key creator in motivation to act
y
which part of the brain sets goals and focuses attention?
pre frontal cortex
also modulates the powerful effects of the reward system
y
what happens to the number of dopamine receptors in addiction?
reduced
why do normal pleasurable experiences not evoke adequate award responses in acute abstinence?
brain reward thresholds are increased
what happens to the changes to the OFC in abstinence?
they persist
what matures first? frontal lobe areas that mediate executive functioning or the limbic system?
limbic system
which parts of brain are critical in acquisition, consolidation and expression of drug stimulus learning?
hippocampus, striatum and amygdala
which part for declarative learning?
hippo
