Anxiolytics

Question 1

name 5 anxiolytic drug classses?

Answer 1

benzodiazapines, antidepressants, buspirone, pregablin, beta blockers

Question 2

what do bentos end in?

Answer 2

zolam, zepam

Question 3

whats the main inhibitory neurone in the brain?

Answer 3

GABA

Question 4

where is glycine neurotransmitter restricted to?

Answer 4

spinal cord and brainstem

Question 5

what can benzodiazepines do in terms of creating new memories?

Answer 5

can give you retrograde amnesia

Question 6

which GABA (A or B) is g protein linked?

Answer 6

B (Gee protein)

Question 7

what do bentos reduce?

Answer 7

aggression and anxiety

Question 8

what do they do to the muscles?

Answer 8

muscle relaxation (brian belly)

Question 9

acute treatment of extreme anxiety?

Answer 9

benzos

Question 10

why would bentos be used to treat extreme anxiety, mania, delirium?

Answer 10

benzos reduce aggression/anxiety, have hypnosis/sedation effect, cause muscle relaxation and have anti convulsant effect

Question 11

why would they be good in alcohol withdrawal?

Answer 11

anti convulsant effect

Question 12

The GABA a receptor has receptors for alcohol, steroids and benzos

Answer 12

y

Question 13

where do ethanol and steroids bind to?

Answer 13

general anaesthetics receptor

Question 14

ethanol, neurosteroids and barbiturates all exhibit what property in humans?

Answer 14

anxiolytic

Question 15

why do bentos have a sedative effect?

Answer 15

they increase activity of GABA A receptors, causing increased chlorine to enter cell. causes hyper polarisation. GABA is main inhibitory neurotransmitter in brain

Question 16

benzos lock GABAa receptor into a conformtion that ….??

Answer 16

increases binding of GABA, increasing Cl and increasing inhibitory effect

Question 17

what is the main excitatory neurotransmitter in the brain?

Answer 17

glutamate (glutamine is a protein, in huntingtons)

Question 18

what can benzodiazepines cause paradoxically?

Answer 18

anger

Question 19

rapid withdrawal from bentos can cause?

Answer 19

think loss of inhibition, increased excitation - sweating, palpitations, anxiety, insomnia, petite loss, perceptual disturbances

Question 20

what class of drug is meclobomide?

Answer 20

RIMA

Question 21

what can venlafaxine be used in? (c4) when wifian

Answer 21

generalised anxiety disorder

Question 22

how do you withdraw bentos? (brian running perth rd)

Answer 22

transfer to equivalent dose of diazepam or chlordiazepoxide. ideally taken at night. reduce every 2-3 weeks. if withdrawals occur, maintain this dose until they subside.

Question 23

how long can withdrawal from bentos take?

Answer 23

4 weeks - 1 year

Question 24

rapid withdrawal - 3 main syptoms ?

Answer 24

toxic psychosis, confusion and even convulsions

Question 25

what can meclobomide be used in?

Answer 25

social phobia

Question 26

side effects of SSRIs?

Answer 26

nausea, dyspepsia, diarrhoea, constipation. sexual dysfunction, anxiety

Question 27

what is the mechanism of sexual dysfunction in SSRIs?

Answer 27

blockade of dopamine and/or 5HT2 activation. Reversed by 5HT2 antagonist or 5HT1a partial agonist

Question 28

what are beta blockers (e.g. propranolol) helpful for?

Answer 28

somatic symtoms ie palpitations and tremor

Question 29

when is prcegablin used?

Answer 29

only if patient not responsive to other treatments

Question 30

what receptors do prcegablin and gabapentin work on?

Answer 30

calcium channels